Search Results - "Alexandre, Leo"

Efficacy and safety profile of statins in patients with cancer: a systematic review of randomised controlled trials by Thomas, John P., Loke, Yoon K., Alexandre, Leo

“…Purpose A growing body of preclinical and observational research suggests that statins have potential as a therapeutic strategy in patients with cancer. This…”
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Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) technique and analgesic efficacy in patients with pancreatic cancer: A systematic review and meta-analysis by Koulouris, A.I., Alexandre, Leo, Hart, A.R., Clark, A.

“…Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN) for the treatment of abdominal pain in pancreatic cancer can be administered in three different…”
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Single Nucleotide Polymorphisms and Post-operative Complications Following Major Gastrointestinal Surgery: a Systematic Review and Meta-analysis by Beecham, Joseph, Hart, Andrew, Alexandre, Leo, Hernon, James, Kumar, Bhaskar, Lam, Stephen

“…Background The human genome is an under-researched area of pre-operative risk stratification. Studies of genetic polymorphisms and their associations with…”
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Dietary antioxidant intake and the risk of developing Barrett’s oesophagus and oesophageal adenocarcinoma by Kang, James H-E, Luben, Robert, Alexandre, Leo, Hart, Andrew R

“…Background We investigated in a cohort study, for the first time using 7-day food diaries (7-DFDs), for age-dependent inverse associations with antioxidants,…”
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Statins as Potential Chemoprevention or Therapeutic Agents in Cancer: a Model for Evaluating Repurposed Drugs by Joharatnam-Hogan, Nalinie, Alexandre, Leo, Yarmolinsky, James, Lake, Blossom, Capps, Nigel, Martin, Richard M, Ring, Alistair, Cafferty, Fay, Langley, Ruth E

“…Purpose of Review Repurposing established medicines for a new therapeutic indication potentially has important global and societal impact. The high costs and…”
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Association Between Statin Use After Diagnosis of Esophageal Cancer and Survival: A Population-Based Cohort Study by Alexandre, Leo, Clark, Allan B, Bhutta, Hina Y, Chan, Simon S.M, Lewis, Michael P.N, Hart, Andrew R

“…Background & Aims Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors), commonly prescribed to prevent cardiovascular disease, promote…”
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Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a β2-adrenoceptor-independent mechanism by MCCORMICK, Cecilia, ALEXANDRE, Leo, THOMPSON, Juliette, MUTUNGI, Gabriel

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Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma by Alexandre, Leo, Long, Elizabeth, Beales, Ian Lp

“…In recent decades there has been a dramatic rise in the incidence of esophageal adenocarcinoma(EAC) in the developed world. Over approximately the same period…”
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Clinical and Endoscopic Characteristics Associated With Post-Endoscopy Upper Gastrointestinal Cancers: A Systematic Review and Meta-analysis by Alexandre, Leo, Tsilegeridis-Legeris, Theo, Lam, Stephen

“…Ten percent of patients with an upper gastrointestinal cancer will have received an esophagogastroduodenoscopy (EGD) within 3 years before diagnosis, termed…”
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Current Evidence to Justify, and the Methodological Considerations for a Randomised Controlled Trial Testing the Hypothesis that Statins Prevent the Malignant Progression of Barrett's Oesophagus by David Thurtle, Leo Alexandre, Yoon K Loke, Ed Cheong, Andrew Hart

“…Barrett's oesophagus is the predominant risk factor for oesophageal adenocarcinoma, a cancer whose incidence is increasing and which has a poor prognosis. This…”
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The Association Between Obesity and Malignant Progression of Barrett’s Esophagus: A Systematic Review and Dose-Response Meta-Analysis by Ko, Mie Thu, Thomas, Tom, Holden, Emily, Beales, Ian L.P., Alexandre, Leo

“…Obesity is a risk factor for both Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). However, it is unclear whether obesity drives the malignant…”
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Opioid burden in patients with inoperable pancreatic adenocarcinoma and the development of a multivariable risk prediction model for opioid use: A retrospective cohort study by Koulouris, Andreas, Baio, Gabriella, Clark, Allan, Alexandre, Leo

“…Risk prediction models to guide patient selection for early pre-emptive endoscopic ultrasound guided coeliac plexus neurolysis are lacking. This study aimed to…”
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Management of upper gastrointestinal haemorrhage by Arkle, Thomas, Alexandre, Leo, Kumar, Bhaskar, Penney, Nicholas

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The association between preoperative cardiopulmonary exercise–test variables and short-term morbidity after esophagectomy: A hospital-based cohort study by Lam, Stephen, Alexandre, Leo, Hardwick, Guy, Hart, Andrew R.

“…Postoperative complications after esophagectomy are thought to be associated with reduced fitness. This observational study explored the associations between…”
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Iron deficiency: a modern primer to diagnosis and management by Alexandre, Leo, Chan, Simon S.M.

“…PURPOSE OF REVIEWIron deficiency with anemia (IDA) and without anemia remain a diagnostic and management challenge. Iron deficiency has a broad spectrum of…”
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Prevalence of gastrointestinal malignancy in iron deficiency without anaemia: A systematic review and meta-analysis by Alexandre, Leo, Manning, Charelle, Chan, Simon S M

“…•The overall risk of gastrointestinal cancer in IDWA is low.•However, older and non-screened populations with IDWA are at a higher risk.•Whilst asymptomatic…”
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The association between physical activity and the risk of symptomatic Barrett’s oesophagus: a UK prospective cohort study by Lam, Stephen, Alexandre, Leo, Luben, Robert, Hart, Andrew R

“…BACKGROUNDPhysical activity affects the functioning of the gastrointestinal system through both local and systemic effects and may play an important role in…”
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BOB CAT: A Large-Scale Review and Delphi Consensus for Management of Barrett's Esophagus With No Dysplasia, Indefinite for, or Low-Grade Dysplasia by Bennett, Cathy, Moayyedi, Paul, Corley, Douglas A, DeCaestecker, John, Falck-Ytter, Yngve, Falk, Gary, Vakil, Nimish, Sanders, Scott, Vieth, Michael, Inadomi, John, Aldulaimi, David, Ho, Khek-Yu, Odze, Robert, Meltzer, Stephen J, Quigley, Eamonn, Gittens, Stuart, Watson, Peter, Zaninotto, Giovanni, Iyer, Prasad G, Alexandre, Leo, Ang, Yeng, Callaghan, James, Harrison, Rebecca, Singh, Rajvinder, Bhandari, Pradeep, Bisschops, Raf, Geramizadeh, Bita, Kaye, Philip, Krishnadath, Sheila, Fennerty, M Brian, Manner, Hendrik, Nason, Katie S, Pech, Oliver, Konda, Vani, Ragunath, Krish, Rahman, Imdadur, Romero, Yvonne, Sampliner, Richard, Siersema, Peter D, Tack, Jan, Tham, Tony C K, Trudgill, Nigel, Weinberg, David S, Wang, Jean, Wang, Kenneth, Wong, Jennie Y Y, Attwood, Stephen, Malfertheiner, Peter, MacDonald, David, Barr, Hugh, Ferguson, Mark K, Jankowski, Janusz

“…Barrett's esophagus (BE) is a common premalignant lesion for which surveillance is recommended. This strategy is limited by considerable variations in clinical…”
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Best analgesia control in pancreatic adenocarcinoma study: justification and feasibility of a randomised trial of early EUS-CPN versus standard care—a prospective observational study (The BAC-PAC study) by Koulouris, Andreas I., Wagner, Adam P., Clark, Allan, Alexandre, Leo

“…Limited and conflicting trial data is available on the efficacy of Endoscopic Ultrasound-guided Coeliac Plexus Neurolysis (EUS-CPN). This study aimed to assess…”
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Statin Use Is Associated With Reduced Risk of Histologic Subtypes of Esophageal Cancer: A Nested Case-Control Analysis by Alexandre, Leo, Clark, Allan B, Bhutta, Hina Y, Holt, Sean, Lewis, Michael P.N, Hart, Andrew R

“…Background & Aims Most patients with esophageal adenocarcinoma (EAC) or squamous cell cancer (ESCC) present with advanced, incurable disease. Statins have…”
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