Search Results - "Alexandra A. Wolfarth"

Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway by Jones, Rheinallt M., Desai, Chirayu, Darby, Trevor M., Luo, Liping, Wolfarth, Alexandra A., Scharer, Christopher D., Ardita, Courtney S., Reedy, April R., Keebaugh, Erin S., Neish, Andrew S.

“…An optimal gut microbiota influences many beneficial processes in the metazoan host. However, the molecular mechanisms that mediate and function in…”
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rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors by Li, Dan, Liang, Tianyuzhou, Hutchins, Laura E, Wolfarth, Alexandra A, Ferrando-Martinez, Sara, Lee, Byung Ha, Ho, Mitchell

“…BackgroundChimeric antigen receptor T-cell (CAR-T) therapy has achieved remarkable remission in patients with B-cell malignancies. However, its efficacy in…”
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A Human Microbiota-Associated Murine Model for Assessing the Impact of the Vaginal Microbiota on Pregnancy Outcomes by Wolfarth, Alexandra A, Smith, Taylor M, VanInsberghe, David, Dunlop, Anne Lang, Neish, Andrew S, Corwin, Elizabeth J, Jones, Rheinallt M

“…Disease states are often linked to large scale changes in microbial community structure that obscure the contributions of individual microbes to disease…”
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Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy by Wolfarth, Alexandra A, Dhar, Swati, Goon, Jack B, Ezeanya, Ugonna I, Ferrando-Martínez, Sara, Lee, Byung Ha

“…The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment…”
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The Role of Interleukin-7 in the Formation of Tertiary Lymphoid Structures and Their Prognostic Value in Gastrointestinal Cancers by Ware, Michael Brandon, Wolfarth, Alexandra A, Goon, Jack B, Ezeanya, Ugonna I, Dhar, Swati, Ferrando-Martinez, Sara, Lee, Byung Ha

“…Immunotherapies for the treatment of solid tumors continue to develop in preclinical and clinical research settings. Unfortunately, for many patients the tumor…”
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Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy by Alexandra A. Wolfarth, Swati Dhar, Jack B. Goon, Ugonna I. Ezeanya, Sara Ferrando-Martínez, Byung Ha Lee

“…The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment…”
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Lactococcus lactis Subspecies cremoris Elicits Protection Against Metabolic Changes Induced by a Western-Style Diet by Naudin, Crystal R., Maner-Smith, Kristal, Owens, Joshua A., Wynn, Grace M., Robinson, Brian S., Matthews, Jason D., Reedy, April R., Luo, Liping, Wolfarth, Alexandra A., Darby, Trevor M., Ortlund, Eric A., Jones, Rheinallt M.

“…A Western-style diet, which is high in fat and sugar, can cause significant dyslipidemia and nonalcoholic fatty liver disease; the diet has an especially…”
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Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models by Campian, Jian L, Ghosh, Subhajit, Kapoor, Vaishali, Yan, Ran, Thotala, Sukrutha, Jash, Arijita, Hu, Tong, Mahadevan, Anita, Rifai, Kasem, Page, Logan, Lee, Byung Ha, Ferrando-Martinez, Sara, Wolfarth, Alexandra A, Yang, Se Hwan, Hallahan, Dennis, Chheda, Milan G, Thotala, Dinesh

“…Patients with glioblastoma (GBM) are treated with radiotherapy (RT) and temozolomide (TMZ). These treatments may cause prolonged systemic lymphopenia, which…”
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Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies by Chandrasekharan, Bindu, Boyer, Darra, Owens, Joshua A, Wolfarth, Alexandra A, Saeedi, Bejan J, Dhere, Tanvi, Iskandar, Heba, Neish, Andrew S

“…Abstract We have demonstrated that neuropeptide Y (NPY) can regulate pro-inflammatory signaling in the gut via cross-talk with the pro-inflammatory cytokine…”
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Serum Amyloid A1 Is an Epithelial Prorestitutive Factor by Hinrichs, Benjamin H., Matthews, Jason D., Siuda, Dorothée, O'Leary, Monique N., Wolfarth, Alexandra A., Saeedi, Bejan J., Nusrat, Asma, Neish, Andrew S.

“…Several proteins endogenously produced during the process of intestinal wound healing have demonstrated prorestitutive properties. The presence of serum…”
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Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis by Wolfarth, Alexandra A., Liu, Xu, Darby, Trevor M., Boyer, Darra J., Spizman, Jocelyn B., Owens, Joshua A., Chandrasekharan, Bindu, Naudin, Crystal R., Hanley, Krisztina Z., Robinson, Brian S., Ortlund, Eric A., Jones, Rheinallt M., Neish, Andrew S.

“…The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment from the microbial…”
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Corrigendum to: Intracolonic Neuropeptide Y Y1 Receptor Inhibition Attenuates Intestinal Inflammation in Murine Colitis and Cytokine Release in IBD Biopsies by Chandrasekharan, Bindu, Boyer, Darra, Owens, Joshua A, Wolfarth, Alexandra A, Saeedi, Bejan J, Dhere, Tanvi, Iskandar, Heba, Neish, Andrew S

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Abstract 6786: NT-I7 as an adjuvant to DNA neoantigen vaccination enhances and prolongs neoantigen-specific anti-tumor immunity by Chen, Michael Y., Chen, Ina, Supabphol, Suangson, Wolfarth, Alexandra A., Martinez, Sara F., Lee, Byung Ha, Li, Lijin, Zhang, Xiuli, Goedgebuure, Peter S., Gillanders, William E.

“…Background: IL-7 is an essential cytokine in the development and maintenance of antigen-specific T cells. NT-I7 (efineptakin alfa; NeoImmuneTech, Inc,…”
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Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy by Alexandra A. Wolfarth, Swati Dhar, Jack B. Goon, Ugonna I. Ezeanya, Sara Ferrando-Martinez, Byung Ha Lee

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Functional Characterization of the Epithelial Protein, PRAP1, and Generation of Human Microbiota-Associated Mice to Model Bacterial Vaginosis by Wolfarth, Alexandra A

“…The microbiota maintains critical interactions with the host at the mucosa of both the gastrointestinal tract and the female reproductive tract. To understand…”
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Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced ApoptosisSummary by Alexandra A. Wolfarth, Xu Liu, Trevor M. Darby, Darra J. Boyer, Jocelyn B. Spizman, Joshua A. Owens, Bindu Chandrasekharan, Crystal R. Naudin, Krisztina Z. Hanley, Brian S. Robinson, Eric A. Ortlund, Rheinallt M. Jones, Andrew S. Neish

“…Background & Aims: The intestinal epithelium must be resilient to physiochemical stress to uphold the physiological barrier separating the systemic compartment…”
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