Search Results - "Alexander Humphries"

Biomechanical comparison of standing posture and during trot between German shepherd and Labrador retriever dogs by Humphries, Alexander, Shaheen, Aliah F, Gómez Álvarez, Constanza B

“…It is widely accepted that canine breeds stand and move differently. The prevalence of various musculoskeletal disorders such as hip and elbow dysplasia is…”
Get full text

The Asymmetric Maitland−Japp Reaction and Its Application to the Construction of the C1−C19 Bis-pyran Unit of Phorboxazole B by Clarke, Paul A, Santos, Soraia, Mistry, Nimesh, Burroughs, Laurence, Humphries, Alexander C

“…The synthesis of the C1−C19 bis-pyran unit of phorboxazole B has been achieved. The key pyran rings were constructed by means of an asymmetric Maitland−Japp…”
Get full text

8-Fluoroimidazo[1,2-a]pyridine: Synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABAA receptor by Humphries, Alexander C., Gancia, Emanuela, Gilligan, Myra T., Goodacre, Simon, Hallett, David, Merchant, Kevin J., Thomas, Steve R.

“…8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques…”
Get full text

Finite element analysis of thermal and acoustic processes during laser tattoo removal by Humphries, Alexander, Lister, Tom S., Wright, Philip A., Hughes, Mike P.

“…Background and Objective Q‐switched laser therapy is commonly used for the removal of tattoos. However, despite ever increasing demand for this intervention, a…”
Get full text

Assessment of the glenohumeral joint's active and passive axial rotational range by Humphries, Alexander, BEng, Cirovic, Srdjan, PhD, Bull, Anthony M.J., PhD, Hearnden, Anthony, MB, Shaheen, Aliah F., PhD

“…Background Assessment of the range of axial rotation of the glenohumeral joint will improve understanding of shoulder function, with applications in shoulder…”
Get full text

A Brønsted Acid Mediated Cascade Enone Synthesis from Aldehydes Containing a Tethered Propargylsilane by Ramalho, Rui, Jervis, Peter J, Kariuki, Benson M, Humphries, Alexander C, Cox, Liam R

“…MeSO3H effects the intramolecular allenylation of a series of aldehydes 1 to provide allenyl alcohol product 3 as a single diastereoisomer. Cyclization…”
Get full text

4-Fluorosulfonylpiperidines: selective 5-HT2A ligands for the treatment of insomnia by Fish, L Rebecca, Gilligan, Myra T, Humphries, Alexander C, Ivarsson, Magnus, Ladduwahetty, Tammy, Merchant, Kevin J, O'Connor, Desmond, Patel, Smita, Philipps, Elisabeth, Vargas, Hugo M, Hutson, Peter H, MacLeod, Angus M

“…Incorporation of fluorine at the 4-position of an existing series of sulfonyl piperidine 5-HT2A antagonists gave compounds with increased selectivity over the…”
Get full text

Shoulder Bone Geometry Affects the Active and Passive Axial Rotational Range of the Glenohumeral Joint by Humphries, Alexander, Cirovic, Srdjan, Shaheen, Aliah F.

“…Background: The range of motion of the glenohumeral joint varies substantially among individuals and is dependent on humeral position. How variation in shape…”
Get full text

Simulated activities of daily living do not replicate functional upper limb movement or reduce movement variability by Taylor, Sarah A.F., Kedgley, Angela E., Humphries, Alexander, Shaheen, Aliah F.

“…Kinematic assessments of the upper limb during activities of daily living (ADLs) are used as an objective measure of upper limb function. The implementation of…”
Get full text

Biomechanical comparison of standing posture and during trot between German shepherd and Labrador retriever dogs by Alexander Humphries, Aliah F Shaheen, Constanza B Gómez Álvarez

“…It is widely accepted that canine breeds stand and move differently. The prevalence of various musculoskeletal disorders such as hip and elbow dysplasia is…”
Get full text

Evidence for a Significant Role of α3-Containing GABAA Receptors in Mediating the Anxiolytic Effects of Benzodiazepines by Dias, Rebecca, Sheppard, Wayne F. A., Fradley, Rosa L., Garrett, Elizabeth M., Stanley, Joanna L., Tye, Spencer J., Goodacre, Simon, Lincoln, Rachael J., Cook, Susan M., Conley, Rachel, Hallett, David, Humphries, Alexander C., Thompson, Sally A., Wafford, Keith A., Street, Leslie J., Castro, J. Luis, Whiting, Paul J., Rosahl, Thomas W., Atack, John R., McKernan, Ruth M., Dawson, Gerard R., Reynolds, David S.

“…The GABA A receptor subtypes responsible for the anxiolytic effects of nonselective benzodiazepines (BZs) such as chlordiazepoxide (CDP) and diazepam remain…”
Get full text

The relationship between shoulder osteology and glenohumeral axial rotation by Humphries, Alexander

“…The range of motion of the Glenohumeral joint (GHJ) varies between individuals and depends on the position of the humerus. Currently there is limited…”
Get full text

8-Fluoroimidazo[1,2-a]pyridine: synthesis, physicochemical properties and evaluation as a bioisosteric replacement for imidazo[1,2-a]pyrimidine in an allosteric modulator ligand of the GABA A receptor by Humphries, Alexander C, Gancia, Emanuela, Gilligan, Myra T, Goodacre, Simon, Hallett, David, Merchant, Kevin J, Thomas, Steve R

“…8-Fluoroimidazo[1,2-a]pyridine has been established as a physicochemical mimic of imidazo[1,2-a]pyrimidine, using both in silico and traditional techniques…”
Get full text

Determination of the thermal and physical properties of black tattoo ink using compound analysis by Humphries, Alexander, Lister, Tom S, Wright, Philip A, Hughes, Michael P

“…Despite the widespread use of laser therapy in the removal of tattoos, comparatively little is known about its mechanism of action. There is a need for an…”
Get full text

Design-driven LO: The discovery of new ultra long acting dibasic β 2-adrenoceptor agonists by Connolly, Stephen, Alcaraz, Lilian, Bailey, Andrew, Cadogan, Elaine, Christie, Jadeen, Cook, Anthony R., Fisher, Adrian J., Hill, Stephen, Humphries, Alexander, Ingall, Anthony H., Kane, Zoe, Paine, Stuart, Pairaudeau, Garry, Stocks, Michael J., Young, Alan

“…Starting with the molecular scaffold of the DA 2/β 2 dual agonist sibenadet (Viozan™), a number of molecular changes were incorporated, which were designed to…”
Get full text

Design driven HtL: The discovery and synthesis of new high efficacy β 2 -agonists by Stocks, Michael J., Alcaraz, Lilian, Bailey, Andrew, Bonnert, Roger, Cadogan, Elaine, Christie, Jadeen, Connolly, Stephen, Cook, Anthony, Fisher, Adrian, Flaherty, Alice, Hill, Stephen, Humphries, Alexander, Ingall, Anthony, Jordan, Stephen, Lawson, Mandy, Mullen, Alex, Nicholls, David, Paine, Stuart, Pairaudeau, Garry, St-Gallay, Stephen, Young, Alan

Get full text

Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action by Stocks, Michael J, Alcaraz, Lilian, Bailey, Andrew, Bonnert, Roger, Cadogan, Elaine, Christie, Jadeen, Dixon, John, Connolly, Stephen, Cook, Anthony, Fisher, Adrian, Flaherty, Alice, Humphries, Alexander, Ingall, Anthony, Jordan, Stephen, Lawson, Mandy, Mullen, Alex, Nicholls, David, Paine, Stuart, Pairaudeau, Garry, Young, Alan

“…A series of dibasic des-hydroxy β2 receptor agonists has been prepared and evaluated for potential as inhaled ultralong acting bronchodilators. Determination…”
Get full text

Non-basic ligands for aminergic GPCRs: The discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists for the treatment of sleep disorders by Ladduwahetty, Tammy, Gilligan, Myra, Humphries, Alexander, Merchant, Kevin J., Fish, Rebecca, McAlister, George, Ivarsson, Magnus, Dominguez, Maria, O’Connor, Desmond, MacLeod, Angus M.

“…Herein is described the development of a non-basic series of aryl sulfones as 5-HT2A receptor antagonists with excellent receptor occupancy on oral dosing in…”
Get full text

Design-driven LO: The discovery of new ultra long acting dibasic beta sub(2-adrenoceptor agonists) by Connolly, Stephen, Alcaraz, Lilian, Bailey, Andrew, Cadogan, Elaine, Christie, Jadeen, Cook, Anthony R, Fisher, Adrian J, Hill, Stephen, Humphries, Alexander, Ingall, Anthony H, Kane, Zoe, Paine, Stuart, Pairaudeau, Garry, Stocks, Michael J, Young, Alan

“…Starting with the molecular scaffold of the DA sub(2/ beta ) sub(2) dual agonist sibenadet (Viozan[TM]), a number of molecular changes were incorporated, which…”
Get full text

Discovery of AZD3199, An Inhaled Ultralong Acting β 2 Receptor Agonist with Rapid Onset of Action by Stocks, Michael J., Alcaraz, Lilian, Bailey, Andrew, Bonnert, Roger, Cadogan, Elaine, Christie, Jadeen, Dixon, John, Connolly, Stephen, Cook, Anthony, Fisher, Adrian, Flaherty, Alice, Humphries, Alexander, Ingall, Anthony, Jordan, Stephen, Lawson, Mandy, Mullen, Alex, Nicholls, David, Paine, Stuart, Pairaudeau, Garry, Young, Alan

Get full text