Search Results - "Alexander, Walker"

Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery by Walker, Alexander P., Fodor, Ervin

“…The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral…”
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Host ANP32A mediates the assembly of the influenza virus replicase by Carrique, Loïc, Fan, Haitian, Walker, Alexander P., Keown, Jeremy R., Sharps, Jane, Staller, Ecco, Barclay, Wendy S., Fodor, Ervin, Grimes, Jonathan M.

“…Aquatic birds represent a vast reservoir from which new pandemic influenza A viruses can emerge 1 . Influenza viruses contain a negative-sense segmented RNA…”
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The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists by Thomas, Sunil, Izard, Jacques, Walsh, Emily, Batich, Kristen, Chongsathidkiet, Pakawat, Clarke, Gerard, Sela, David A, Muller, Alexander J, Mullin, James M, Albert, Korin, Gilligan, John P, DiGuilio, Katherine, Dilbarova, Rima, Alexander, Walker, Prendergast, George C

“…Humans consider themselves discrete autonomous organisms, but recent research is rapidly strengthening the appreciation that associated microorganisms make…”
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Structures of influenza A virus RNA polymerase offer insight into viral genome replication by Fan, Haitian, Walker, Alexander P., Carrique, Loïc, Keown, Jeremy R., Serna Martin, Itziar, Karia, Dimple, Sharps, Jane, Hengrung, Narin, Pardon, Els, Steyaert, Jan, Grimes, Jonathan M., Fodor, Ervin

“…Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to humans 1 , 2…”
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Aprotinin during Coronary-Artery Bypass Grafting and Risk of Death by Schneeweiss, Sebastian, Seeger, John D, Landon, Joan, Walker, Alexander M

“…Aprotinin (Trasylol) is used to control bleeding during coronary-artery bypass grafting (CABG), but in this observational study, there was an increased risk of…”
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Semiparametric Allocation of Subjects to Cohort Strata by Walker, Alexander M, Russo, Massimiliano, Schneeweiss, Maria C, Glynn, Robert J

“…We illustrate a method for stratum assignment in small cohort studies that avoids modeling assumptions. Off-the-shelf software ( rgenoud ) made stratum…”
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Mutation of an Influenza Virus Polymerase 3' RNA Promoter Binding Site Inhibits Transcription Elongation by Walker, Alexander P, Sharps, Jane, Fodor, Ervin

“…Influenza viruses encode a viral RNA-dependent RNA polymerase (FluPol), which is responsible for transcribing and replicating the negative-sense viral RNA…”
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The SARS-CoV-2 RNA polymerase is a viral RNA capping enzyme by Walker, Alexander P, Fan, Haitian, Keown, Jeremy R, Knight, Michael L, Grimes, Jonathan M, Fodor, Ervin

“…Abstract SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic, which continues to cause significant…”
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Elucidation of the Structure and Reaction Mechanism of Sorghum Hydroxycinnamoyltransferase and Its Structural Relationship to Other Coenzyme A-Dependent Transferases and Synthases by Walker, Alexander M., Hayes, Robert P., Youn, Buhyun, Vermerris, Wilfred, Sattler, Scott E., Kang, ChulHee

“…Hydroxycinnamoyltransferase (HCT) from sorghum (Sorghum bicolor) participates in an early step of the phenylpropanoid pathway, exchanging coenzyme A (CoA)…”
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Matching on provider is risky by Walker, Alexander M

“…Abstract Objectives To illustrate that matching on provider may exacerbate, not remove, bias. Study Design and Setting The degree of confounding bias depends…”
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For drug-induced carcinogenesis, the observations are the hypothesis: Invited editorial for the Mini-Symposium on Cancer Pharmacoepidemiology by Walker, Alexander M.

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Culture as a Moderator of Epistemically Suspect Beliefs by Majima, Yoshimasa, Walker, Alexander C, Turpin, Martin Harry, Fugelsang, Jonathan A

“…A consistent finding reported in the literature is that epistemically suspect beliefs (e.g., paranormal beliefs) are less frequently endorsed by individuals…”
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Characterization of the SARS-CoV-2 ExoN (nsp14ExoN–nsp10) complex: implications for its role in viral genome stability and inhibitor identification by Baddock, Hannah T, Brolih, Sanja, Yosaatmadja, Yuliana, Ratnaweera, Malitha, Bielinski, Marcin, Swift, Lonnie P, Cruz-Migoni, Abimael, Fan, Haitian, Keown, Jeremy R, Walker, Alexander P, Morris, Garrett M, Grimes, Jonathan M, Fodor, Ervin, Schofield, Christopher J, Gileadi, Opher, McHugh, Peter J

“…Abstract The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-CoV-2 belongs to an order, Nidovirales, with very large RNA…”
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Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway by Butkovič, Rebeka, Walker, Alexander P., Healy, Michael D., McNally, Kerrie E., Liu, Meihan, Veenendaal, Tineke, Kato, Kohji, Liv, Nalan, Klumperman, Judith, Collins, Brett M., Cullen, Peter J.

“…Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the…”
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Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies by Keown, Jeremy R., Zhu, Zihan, Carrique, Loïc, Fan, Haitian, Walker, Alexander P., Serna Martin, Itziar, Pardon, Els, Steyaert, Jan, Fodor, Ervin, Grimes, Jonathan M.

“…Influenza A viruses cause seasonal epidemics and global pandemics, representing a considerable burden to healthcare systems. Central to the replication cycle…”
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Complementary hypotheses in safety surveillance by Walker, Alexander M.

“…Postmarketing safety surveillance studies address two actionable questions: (1) Is the test product riskier than a standard? (2) Is the risk associated with…”
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Structural and Biochemical Characterization of Cinnamoyl-CoA Reductases by Sattler, Steven A., Walker, Alexander M., Vermerris, Wilfred, Sattler, Scott E., Kang, ChulHee

“…Cinnamoyl-coenzyme A reductase (CCR) catalyzes the reduction of hydroxycinnamoyl-coenzyme A (CoA) esters using NADPH to produce hydroxycinnamyl aldehyde…”
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When the river meets the sea: Transport and provenance in a long‐lived estuary by Zametzer, Andreas, Dröllner, Maximilian, Kirkland, Christopher L., Barham, Milo, Walker, Alexander T., Requilme, Lloyd

“…Unravelling source‐to‐sink relationships of sediment in coastal regions can be particularly challenging due to a variety of transport directions and mixing…”
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An Evaluation of the Effect of the OxyContin Reformulation on Unintentional Fatal and Nonfatal Overdose by Beachler, Daniel C., Hall, Kelsey, Garg, Renu, Banerjee, Geetanjoli, Li, Ling, Boulanger, Luke, Yuce, Huseyin, Walker, Alexander M.

“…OxyContin was reformulated with a polyethylene oxide matrix in August 2010 to reduce the potential for intravenous abuse and for abuse by insufflation. The…”
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Results of Multivariable Logistic Regression, Propensity Matching, Propensity Adjustment, and Propensity-based Weighting under Conditions of Nonuniform Effect by Kurth, Tobias, Walker, Alexander M., Glynn, Robert J., Chan, K. Arnold, Gaziano, J. Michael, Berger, Klaus, Robins, James M.

“…Observational studies often provide the only available information about treatment effects. Control of confounding, however, remains challenging. The authors…”
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