The Natural History of Community-Acquired Hepatitis C in the United States

The Natural History of Community-Acquired Hepatitis C in the United States

ONE of the most important features of non-A, non-B hepatitis is the frequency with which chronic liver disease develops. Most studies of chronic non-A, non-B hepatitis have been follow-up studies of patients who have received transfusions. An average of 50 percent of these patients were shown to hav...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 327; no. 27; pp. 1899 - 1905
Main Authors: Alter, Miriam J, Margolis, Harold S, Krawczynski, Krzysztof, Judson, Franklyn N, Mares, Allene, Alexander, W.James, Hu, Pin Ya, Miller, Joan K, Gerber, Michael A, Sampliner, Richard E, Meeks, Emory L, Beach, Michael J
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 31-12-1992
Subjects:
Biological and medical sciences
Chronic active hepatitis
Chronic infection
DNA-directed RNA polymerase
Hepatitis
Hepatitis C
hepatitis C virus
Human viral diseases
Illnesses
Infectious diseases
Liver cirrhosis
Liver diseases
Medical sciences
Non-A, non-B hepatitis
Patients
Ribonucleic acid
Risk factors
RNA
Viral diseases
Viral hepatitis
United States
North America
America
USA
Human
Infection
Acquired
Digestive diseases
Evolution
Hepatic disease
Community
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Summary:ONE of the most important features of non-A, non-B hepatitis is the frequency with which chronic liver disease develops. Most studies of chronic non-A, non-B hepatitis have been follow-up studies of patients who have received transfusions. An average of 50 percent of these patients were shown to have persistently elevated serum aminotransferase levels, and of those who underwent liver biopsy, 60 percent had chronic active hepatitis and 10 to 20 percent had cirrhosis. 1 Only a few studies have examined the rate and severity of chronic liver disease in patients who did not acquire their infections from blood transfusions. 2 3 4 5 6 7 In these . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199212313272702