Search Results - "Alexander, Rikki"

Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions by Brand, Michael, Measures, Angelina M, Wilson, Brian G, Cortopassi, Wilian A, Alexander, Rikki, Höss, Matthias, Hewings, David S, Rooney, Timothy P. C, Paton, Robert S, Conway, Stuart J

“…Bromodomains are protein modules that bind to acetylated lysine residues. Their interaction with histone proteins suggests that they function as “readers” of…”
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Structure of an Allosteric Inhibitor of LFA-1 Bound to the I-Domain Studied by Crystallography, NMR, and Calorimetry by Crump, Matthew P, Ceska, Thomas A, Spyracopoulos, Leo, Henry, Alistair, Archibald, Sarah C, Alexander, Rikki, Taylor, Richard J, Findlow, Stuart C, O'Connell, James, Robinson, Martyn K, Shock, Anthony

“…LFA-1 (lymphocyte function-associated antigen-1) plays a role in intercellular adhesion and lymphocyte trafficking and activation and is an attractive…”
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Squaric acid derivatives as VLA-4 integrin antagonists by PORTER, John R, ARCHIBALD, Sarah C, WARRELLOW, Graham J, ALEXANDER, Rikki P, LANGHAM, Barry, CHILDS, Kirstie, CRITCHLEY, David, HEAD, John C, LINSLEY, Janeen M, PARTON, Ted A. H, ROBINSON, Martyn K, SHOCK, Anthony, TAYLOR, Richard J

“…SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series…”
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Correction to Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions by Brand, Michael, Measures, Angelina R, Wilson, Brian G, Cortopassi, Wilian A, Alexander, Rikki, Höss, Matthias, Hewings, David S, Rooney, Timothy P. C, Paton, Robert S, Conway, Stuart J

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4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase by Alexander, Rikki, Balasundaram, Ahrani, Batchelor, Mark, Brookings, Daniel, Crépy, Karen, Crabbe, Tom, Deltent, Marie-France, Driessens, Frank, Gill, Andrew, Harris, Sue, Hutchinson, Gillian, Kulisa, Claire, Merriman, Mark, Mistry, Prakash, Parton, Ted, Turner, James, Whitcombe, Ian, Wright, Sara

“…4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase, compound 18 is shown to…”
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The use of enantiomerically pure ketene dithioacetal bis(sulfoxides) in highly diastereoselective intramolecular nitrone cycloadditions. Application in the total synthesis of the beta-amino acid (-)-cispentacin and the first asymmetric synthesis of cis-(3R,4R)-4-amino-pyrrolidine-3-carboxylic acid by Aggarwal, Varinder K, Roseblade, Stephen, Alexander, Rikki

“…Intramolecular 1,3-dipolar nitrone cycloaddition onto an enantiomerically pure ketene dithioacetal dioxide using a three-carbon tether gave the corresponding…”
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Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines by Perry, Benjamin, Alexander, Rikki, Bennett, Gavin, Buckley, George, Ceska, Tom, Crabbe, Tom, Dale, Verity, Gowers, Lewis, Horsley, Helen, James, Lynwen, Jenkins, Kerry, Crépy, Karen, Kulisa, Claire, Lightfoot, Helen, Lock, Chris, Mack, Stephen, Morgan, Trevor, Nicolas, Anne-Lise, Pitt, Will, Sabin, Verity, Wright, Sara

“…The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed. The SAR…”
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Highly Diastereoselective Nitrone Cycloaddition onto a Chiral Ketene Equivalent:  Asymmetric Synthesis of Cispentacin by Aggarwal, Varinder K, Roseblade, Stephen J, Barrell, Juliet K, Alexander, Rikki

“…A highly diastereoselective intramolecular nitrone cycloaddition onto a chiral ketene equivalent, obtained by Horner−Wadsworth−Emmons olefination of either…”
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Highly Diastereoselective Epoxidation of Ketene Dithioacetal Dioxides:  A New Approach to the Asymmetric Synthesis of α-Amino Amides by Aggarwal, Varinder K, Barrell, Juliet K, Worrall, Julia M, Alexander, Rikki

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A N-nitrosochloroethyl-cephalosporin carbamate prodrug for antibody-directed enzyme prodrug therapy (ADEPT) by Alexander, Rikki P., Bates, Robert W., Pratt, Andrew J., Kraunsoe, James A.E.

“…N-Nitrosochloroethyl-cephem 7 was prepared via acylation and selective nitrosation of a cephalothin derivative. This cephalosporin is an efficient substrate…”
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AN-nitrosochloroethyl-cephalosporin carbamate prodrug for antibody-directed enzyme prodrug therapy (ADEPT) by Alexander, Rikki P., Bates, Robert W., Pratt, Andrew J., Kraunsoe, James A.E.

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Stereoselective Epoxidation of bis-Sulfinyl Alkenes and Application to the Asymmetric Synthesis of α-Substituted Carboxylic Acids by Aggarwal, Varinder K., Worrall, Julia M., Alexander, Rikki

“…Ketene thioacetals 3 can be easily prepared in optically pure form and react diastereoselectively with metal peroxides. The resulting bis-sulfinyl oxiranes can…”
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Diastereomerically Pure Spirocyclic Bis-Sulfinyl Oxiranes and their Application to the Asymmetric Synthesis of α-Amino Amides by Aggarwal, Varinder K., Barrell, Juliet K., Worrall, Julia M., Alexander, Rikki

“…Optically pure spirocyclic bis-sulfinyl oxiranes 4 have been prepared and converted in a single step into α-amino amides…”
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