Search Results - "Alexander, Mark J."

Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension by Joshi, Sachindra R., Liu, Jun, Bloom, Troy, Karaca Atabay, Elif, Kuo, Tzu-Hsing, Lee, Michael, Belcheva, Elitza, Spaits, Matthew, Grenha, Rosa, Maguire, Michelle C., Frost, Jeffrey L., Wang, Kathryn, Briscoe, Steven D., Alexander, Mark J., Herrin, Brantley R., Castonguay, Roselyne, Pearsall, R. Scott, Andre, Patrick, Yu, Paul B., Kumar, Ravindra, Li, Gang

“…Sotatercept is an activin receptor type IIA-Fc (ActRIIA-Fc) fusion protein that improves cardiopulmonary function in patients with pulmonary arterial…”
Get full text

Therapeutic Approaches for Treating Pulmonary Arterial Hypertension by Correcting Imbalanced TGF-β Superfamily Signaling by Andre, Patrick, Joshi, Sachindra R, Briscoe, Steven D, Alexander, Mark J, Li, Gang, Kumar, Ravindra

“…Pulmonary arterial hypertension (PAH) is a rare disease characterized by high blood pressure in the pulmonary circulation driven by pathological remodeling of…”
Get full text

Activin receptor antagonists for cancer-related anemia and bone disease by Fields, Scott Z, Parshad, Shiroo, Anne, Madhurima, Raftopoulos, Haralambos, Alexander, Mark J, Sherman, Matthew L, Laadem, Abderrahmane, Sung, Victoria, Terpos, Evangelos

“…Antagonists of activin receptor signaling may be beneficial for cancer-related anemia and bone disease caused by malignancies such as multiple myeloma and…”
Get more information

Sotatercept analog improves cardiopulmonary remodeling and pulmonary hypertension in experimental left heart failure by Joshi, Sachindra R, Atabay, Elif Karaca, Liu, Jun, Ding, Yan, Briscoe, Steven D, Alexander, Mark J, Andre, Patrick, Kumar, Ravindra, Li, Gang

“…Pulmonary hypertension due to left heart disease (PH-LHD) is the most frequent manifestation of PH but lacks any approved treatment. Activin receptor type…”
Get full text

Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis by Suragani, Rajasekhar N V S, Cadena, Samuel M, Cawley, Sharon M, Sako, Dianne, Mitchell, Dianne, Li, Robert, Davies, Monique V, Alexander, Mark J, Devine, Matthew, Loveday, Kenneth S, Underwood, Kathryn W, Grinberg, Asya V, Quisel, John D, Chopra, Rajesh, Pearsall, R Scott, Seehra, Jasbir, Kumar, Ravindra

“…Rajasekhar Suragani et al . show that a modified activin receptor IIB ligand trap increases red blood cell numbers in mice, rats and monkeys and ameliorates…”
Get full text

Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes by Verma, Amit, Suragani, Rajasekhar Nvs, Aluri, Srinivas, Shah, Nishi, Bhagat, Tushar D, Alexander, Mark J, Komrokji, Rami, Kumar, Ravi

“…Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to…”
Get full text

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia by Suragani, Rajasekhar N.V.S., Cawley, Sharon M., Li, Robert, Wallner, Samantha, Alexander, Mark J., Mulivor, Aaron W., Gardenghi, Sara, Rivella, Stefano, Grinberg, Asya V., Pearsall, R. Scott, Kumar, Ravindra

“…In β-thalassemia, unequal production of α- and β-globin chains in erythroid precursors causes apoptosis and inhibition of late-stage erythroid differentiation,…”
Get full text

ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders by Li, Jia, Fredericks, Maureen, Cannell, Marishka, Wang, Kathryn, Sako, Dianne, Maguire, Michelle C, Grenha, Rosa, Liharska, Katia, Krishnan, Lavanya, Bloom, Troy, Belcheva, Elitza P, Martinez, Pedro A, Castonguay, Roselyne, Keates, Sarah, Alexander, Mark J, Choi, Hyunwoo, Grinberg, Asya V, Pearsall, R Scott, Oh, Paul, Kumar, Ravindra, Suragani, Rajasekhar Nvs

“…Patients with neuromuscular disorders suffer from a lack of treatment options for skeletal muscle weakness and disease comorbidities. Here, we introduce as a…”
Get full text

Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor by Alexander, Mark J., Leeman, Susan E.

“…The peptides neurotensin (NT) and neuromedin N exert effects on neurons by means of a high‐affinity NT receptor (NTRH) belonging to the superfamily of…”
Get full text

Colocalization of neurotensin messenger ribonucleic acid (mRNA) and progesterone receptor mRNA in rat arcuate neurons under estrogen-stimulated conditions by Alexander, M J

“…In the female rat, estrogen and progesterone directly or indirectly regulate the activity of neurotensin (NT)-synthesizing neurosecretory cells located in the…”
Get full text

Colocalization of Neurotensin Messenger Ribonucleic Acid (mRNA) and Progesterone Receptor mRNA in Rat Arcuate Neurons under Estrogen-Stimulated Conditions1 by Alexander, Mark J

“…In the female rat, estrogen and progesterone directly or indirectly regulate the activity of neurotensin (NT)-synthesizing neurosecretory cells located in the…”
Get full text

Effects of prenatal malnutrition on GABAA receptor α1, α3 and β2 mRNA levels by Steiger, Janine L, Alexander, Mark J, Galler, Janina R, Farb, David H, Russek, Shelley J

“…Exposure of pregnant rats to protein malnutrition throughout pregnancy alters the developing hippocampus, leading to increased inhibition and selective changes…”
Get full text

Sexually dimorphic distribution of neurotensin/neuromedin N mRNA in the rat preoptic area by Alexander, M J, Kiraly, Z J, Leeman, S E

“…Neurotensin release from estrogen-responsive neurons in the rostral preoptic area of the female rat may play an important role in triggering preovulatory…”
Get more information

Transforming growth factor-[beta] superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis by Suragani, Rajasekhar N V S, Cadena, Samuel M, Cawley, Sharon M, Sako, Dianne, Mitchell, Dianne, Li, Robert, Davies, Monique V, Alexander, Mark J, Devine, Matthew, Loveday, Kenneth S, Underwood, Kathryn W, Grinberg, Asya V, Quisel, John D, Chopra, Rajesh, Pearsall, R Scott, Seehra, Jasbir, Kumar, Ravindra

“…Erythropoietin (EPO) stimulates proliferation of early-stage erythrocyte precursors and is widely used for the treatment of chronic anemia. However, several…”
Get full text

Neurotensin and Neuroendocrine Regulation by Rostène, William H., Alexander, Mark J.

“…More than two decades of research indicate that the peptide neurotensin (NT) and its cognate receptors participate to a remarkable extent in the regulation of…”
Get full text

Colocalization of Neurotensin Messenger Ribonucleic Acid (mRNA) and Progesterone Receptor mRNA in Rat Arcuate Neurons under Estrogen-Stimulated Conditions 1 by Alexander, Mark J.

Get full text

Effects of prenatal malnutrition on GABAA receptor alpha1, alpha3 and beta2 mRNA levels by Steiger, Janine L, Alexander, Mark J, Galler, Janina R, Farb, David H, Russek, Shelley J

“…Exposure of pregnant rats to protein malnutrition throughout pregnancy alters the developing hippocampus, leading to increased inhibition and selective changes…”
Get full text

Estrogen-regulated synthesis of neurotensin in neurosecretory cells of the hypothalamic arcuate nucleus in the female rat by Alexander, M J

“…Neurotensin (NT) is implicated as a neurohormone in mammals, yet the peptide's neuroendocrine role remains to be determined. NT immunoreactivity has been…”
Get more information

Estrogen-inducible neurotensin immunoreactivity in the preoptic area of the female rat by Alexander, M J, Leeman, S E

“…Neurotensin (NT) neurons in the rat preoptic area are implicated in female-specific regulation of reproduction. Estrogen markedly increases expression of mRNA…”
Get more information

Distribution of Neurotensin/Neuromedin N mRNA in Rat Forebrain: Unexpected Abundance in Hippocampus and Subiculum by Alexander, Mark J., Miller, Margaret A., Dorsa, Daniel M., Bullock, Bryant P., Melloni, Richard H., Dobner, Paul R., Leeman, Susan E.

“…We have used in situ hybridization to determine the regional distribution of mRNA encoding the neurotensin/neuromedin N (NT/N) precursor in the forebrain of…”
Get full text