Search Results - "Alexander, Leslie D"

Synthesis of sansalvamide A peptidomimetics: triazole, oxazole, thiazole, and pseudoproline containing compounds by Davis, Melinda R., Singh, Erinprit K., Wahyudi, Hendra, Alexander, Leslie D., Kunicki, Joseph B., Nazarova, Lidia A., Fairweather, Kelly A., Giltrap, Andrew M., Jolliffe, Katrina A., McAlpine, Shelli R.

“…Peptidomimetic-based macrocycles typically have improved pharmacokinetic properties over those observed with peptide analogs. Described are the syntheses of 13…”
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Macrocyclic inhibitors of hsp90 by Johnson, Victoria A, Singh, Erinprit K, Nazarova, Lidia A, Alexander, Leslie D, McAlpine, Shelli R

“…Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over…”
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Towards a predictive framework for biocrust mediation of plant performance: A meta‐analysis by Havrilla, Caroline A., Chaudhary, V. Bala, Ferrenberg, Scott, Antoninka, Anita J., Belnap, Jayne, Bowker, Matthew A., Eldridge, David J., Faist, Akasha M., Huber‐Sannwald, Elisabeth, Leslie, Alexander D., Rodriguez‐Caballero, Emilio, Zhang, Yuanming, Barger, Nichole N., Vries, Franciska

“…Understanding the importance of biotic interactions in driving the distribution and abundance of species is a central goal of plant ecology. Early vascular…”
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Biocrusts are associated with increased plant biomass and nutrition at seedling stage independently of root-associated fungal colonization by Havrilla, Caroline, Leslie, Alexander D., Di Biase, Jacob L., Barger, Nichole N.

“…Aims Plant-soil interactions are important drivers of plant productivity and community structure. Biocrusts – soil surface-dwelling biotic communities…”
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Macrocycles That Inhibit the Binding between Heat Shock Protein 90 and TPR-Containing Proteins by Ardi, Veronica C, Alexander, Leslie D, Johnson, Victoria A, McAlpine, Shelli R

“…Heat shock protein 90 (Hsp90) accounts for 1–2% of the total proteins in normal cells and functions as a molecular chaperone that folds, assembles, and…”
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Design and synthesis of Hsp90 inhibitors: Exploring the SAR of Sansalvamide A derivatives by Sellers, Robert P., Alexander, Leslie D., Johnson, Victoria A., Lin, Chun-Chieh, Savage, Jeremiah, Corral, Ricardo, Moss, Jason, Slugocki, Tim S., Singh, Erinprit K., Davis, Melinda R., Ravula, Suchitra, Spicer, Jamie E., Oelrich, Jenna L., Thornquist, Andrea, Pan, Chung-Mao, McAlpine, Shelli R.

“…Utilizing the structure–activity relationship we have developed during the synthesis of the first two generations and mechanism of action studies that point to…”
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Synthesis and evaluation of biotinylated sansalvamide A analogs and their modulation of Hsp90 by Kunicki, Joseph B., Petersen, Mark N., Alexander, Leslie D., Ardi, Veronica C., McConnell, Jeanette R., McAlpine, Shelli R.

“…Described are the syntheses of three sansalvamide A derivatives that contain biotinylated tags at individual positions around the macrocycle. The tagged…”
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A small molecule that preferentially binds the closed conformation of Hsp90 by Alexander, Leslie D., Partridge, James R., Agard, David A., McAlpine, Shelli R.

“…Described is the synthesis of three different fluorescein-tagged derivatives of a macrocycle, and their binding affinity to heat shock protein 90 (Hsp90)…”
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An Hsp90 modulator that exhibits a unique mechanistic profile by Ramsey, Deborah M., McConnell, Jeanette R., Alexander, Leslie D., Tanaka, Kaishin W., Vera, Chester M., McAlpine, Shelli R.

“…Described is the synthesis of two biotinylated derivatives of a cytotoxic macrocycle. Pull-down assays indicate that this macrocycle targets the N-middle…”
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Histone deacetylase inhibitors: synthesis of cyclic tetrapeptides and their triazole analogs by Singh, Erinprit K., Nazarova, Lidia A., Lapera, Stephanie A., Alexander, Leslie D., McAlpine, Shelli R.

“…Synthesis of nine macrocyclic peptide HDAC inhibitors and three triazole derivatives is described. HDAC inhibitory activity of these compounds against HeLa…”
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Evaluation of Di-Sansalvamide A Derivatives: Synthesis, Structure−Activity Relationship, and Mechanism of Action by Alexander, Leslie D, Sellers, Robert P, Davis, Melinda R, Ardi, Veronica C, Johnson, Victoria A, Vasko, Robert C, McAlpine, Shelli R

“…Described is the SAR of 18 di-sansalvamide A derivatives and the mechanism of action of the most potent compound. We show that this scaffold is a promising…”
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Conformationally based design of macrocycles as antitumor agents by Singh, Erinprit K, Sellers, Robert P, Alexander, Leslie D, McAlpine, Shelli R

“…A key feature for any chemotherapeutic agent is a favorable conformation when it is presenting itself to its intended target. Numerous macrocycles have been…”
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