Search Results - "Alexander, Lacy"

Heat Waves, Aging, and Human Cardiovascular Health by KENNEY, W LARRY, CRAIGHEAD, DANIEL H, ALEXANDER, LACY M

“…ABSTRACTThis brief review is based on a President’s Lecture presented at the Annual Meeting of the American College of Sports Medicine in 2013. The purpose of…”
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Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia by Stanhewicz, Anna E, Jandu, Sandeep, Santhanam, Lakshmi, Alexander, Lacy M

“…Women who have had preeclampsia have increased cardiovascular disease risk; however, the mechanism(s) responsible for this association remain unclear…”
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Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder by Greaney, Jody L, Saunders, Erika F.H, Santhanam, Lakshmi, Alexander, Lacy M

“…RATIONALE:In rodent models of depression, oxidative stress-induced reductions in NO bioavailability contribute to impaired endothelium-dependent dilation…”
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Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia by Stanhewicz, Anna E, Alexander, Lacy M

“…Despite remission of clinical symptoms postpartum, women who have had preeclampsia demonstrate microvascular endothelial dysfunction, mediated in part by…”
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Why gender equity should remain a focus for the American Physiological Society by Stachenfeld, Nina S, Alexander, Lacy M

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Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection by Dillon, Gabrielle A, Wolf, S Tony, Alexander, Lacy M

“…Vascular dysfunction has been reported in adults who have recovered from COVID-19. To date, no studies have investigated the underlying mechanisms of…”
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Inhibition of nuclear factor-κB activation improves non-nitric oxide-mediated cutaneous microvascular function in reproductive-aged healthy women by Content, Virginia G, Williams, Auni C, Alexander, Lacy M

“…The transcriptional regulator nuclear factor-κB (NF-κB) is a mediator of endothelial dysfunction. Inhibiting NF-κB with salsalate is used to investigate…”
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Four weeks of vitamin D supplementation improves nitric oxide-mediated microvascular function in college-aged African Americans by Wolf, S Tony, Jablonski, Nina G, Ferguson, Sara B, Alexander, Lacy M, Kenney, W Larry

“…Reduced nitric oxide (NO)-mediated cutaneous vasodilation, secondary to increased oxidative stress, presents in young African American (AA) compared with…”
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Folic acid supplementation improves microvascular function in older adults through nitric oxide-dependent mechanisms by Stanhewicz, Anna E, Alexander, Lacy M, Kenney, W Larry

“…Older adults have reduced vascular endothelial function, evidenced by attenuated nitric oxide (NO)-dependent cutaneous vasodilatation. Folic acid and its…”
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Impaired Hydrogen Sulfide–Mediated Vasodilation Contributes to Microvascular Endothelial Dysfunction in Hypertensive Adults by Greaney, Jody L, Kutz, Jessica L, Shank, Sean W, Jandu, Sandeep, Santhanam, Lakshmi, Alexander, Lacy M

“…Reductions in hydrogen sulfide (H2S) production have been implicated in the pathogenesis of vascular dysfunction in animal models of hypertension; however, no…”
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Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia by Stanhewicz, Anna E, Jandu, Sandeep, Santhanam, Lakshmi, Alexander, Lacy M

“…Microvascular dysfunction originating during a preeclamptic pregnancy persists postpartum and probably contributes to increased CVD risk in these women. One…”
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Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder by Greaney, Jody L, Saunders, Erika F H, Alexander, Lacy M

“…Reactive oxygen species (ROS)-mediated reductions in nitric oxide (NO)-dependent dilation are evident in adults with major depressive disorder (MDD); however,…”
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Letter to the Editor in response to: Microvascular endothelial function following the cessation of long‐term oral contraceptive pill use: A case report by Kirby, Nathalie V., Stachenfeld, Nina S., Alexander, Lacy M.

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Vascular aging by Seals, Douglas R, Alexander, Lacy M

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Skeleton-secreted PDGF-BB mediates arterial stiffening by Santhanam, Lakshmi, Liu, Guanqiao, Jandu, Sandeep, Su, Weiping, Wodu, Bulouere P, Savage, William, Poe, Alan, Liu, Xiaonan, Alexander, Lacy M, Cao, Xu, Wan, Mei

“…Evidence links osteoporosis and cardiovascular disease but the cellular and molecular mechanisms are unclear. Here we identify skeleton-secreted…”
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Women with a history of preeclampsia have preserved sensory nerve‐mediated dilatation in the cutaneous microvasculature by Pyevich, Michael, Alexander, Lacy M, Stanhewicz, Anna E.

“…New Findings What is the central question of this study? Are sensory nerve‐mediated vasodilatation and the NO‐dependent contribution to that response…”
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Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature by Kutz, Jessica L., Greaney, Jody L., Santhanam, Lakshmi, Alexander, Lacy M.

“…Key points Hydrogen sulphide (H2S) is vasoprotective, attenuates inflammation and modulates blood pressure in animal models; however, its specific mechanistic…”
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Hydrogen sulfide-dependent microvascular vasodilation is improved following chronic sulfhydryl-donating antihypertensive pharmacotherapy in adults with hypertension by Dillon, Gabrielle A, Stanhewicz, Anna E, Serviente, Corinna, Greaney, Jody L, Alexander, Lacy M

“…Hypertension is characterized by systemic microvascular endothelial dysfunction, in part due to a functional absence of hydrogen sulfide (H S)-mediated…”
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Nonuniform, age-related decrements in regional sweating and skin blood flow by Smith, Caroline J, Alexander, Lacy M, Kenney, W Larry

“…Aging is associated with attenuated thermoregulatory function that varies regionally over the body. Decrements in vasodilation and sweating are well documented…”
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Healthy active older adults have enhanced K + channel-dependent endothelial vasodilatory mechanisms by Serviente, Corinna, Berry, Craig W, Kenney, W Larry, Alexander, Lacy M

“…Microvascular endothelial dysfunction, a precursor to atherosclerotic cardiovascular disease, increases with aging. Endothelium-derived hyperpolarizing factors…”
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