Search Results - "Alexander, L.R."

Family Wellbeing and Sexual Health of Patients Receiving Treatment for Prostate Cancer by Rio, Carielle Joy, Goto, Taichi, Hsiao, Chao-Pin, Ross, Alexander L.R, Saligan, Leorey N

“…Purpose: Prostate cancer and its treatment may affect patients' sexual function and social wellbeing. This study investigated the relationship between…”
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Carbonic Anhydrase 9 Expression Increases with Vascular Endothelial Growth Factor–Targeted Therapy and Is Predictive of Outcome in Metastatic Clear Cell Renal Cancer by Stewart, Grant D, O’Mahony, Fiach C, Laird, Alexander, Rashid, Sukaina, Martin, Sarah A, Eory, Lel, Lubbock, Alexander L.R, Nanda, Jyoti, O’Donnell, Marie, Mackay, Alan, Mullen, Peter, McNeill, S. Alan, Riddick, Antony C.P, Aitchison, Michael, Berney, Daniel, Bex, Axel, Overton, Ian M, Harrison, David J, Powles, Thomas

“…Abstract Background There is a lack of biomarkers to predict outcome with targeted therapy in metastatic clear cell renal cancer (mccRCC). This may be because…”
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Functional Transcription Factor Target Networks Illuminate Control of Epithelial Remodelling by Overton, Ian M, Sims, Andrew H, Owen, Jeremy A, Heale, Bret S E, Ford, Matthew J, Lubbock, Alexander L R, Pairo-Castineira, Erola, Essafi, Abdelkader

“…Cell identity is governed by gene expression, regulated by transcription factor (TF) binding at cis-regulatory modules. Decoding the relationship between TF…”
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Processes in DNA damage response from a whole-cell multi-omics perspective by Pino, James C., Lubbock, Alexander L.R., Harris, Leonard A., Gutierrez, Danielle B., Farrow, Melissa A., Muszynski, Nicole, Tsui, Tina, Sherrod, Stacy D., Norris, Jeremy L., McLean, John A., Caprioli, Richard M., Wikswo, John P., Lopez, Carlos F.

“…Technological advances have made it feasible to collect multi-condition multi-omic time courses of cellular response to perturbation, but the complexity of…”
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Microbench: automated metadata management for systems biology benchmarking and reproducibility in Python by Lubbock, Alexander L R, Lopez, Carlos F

“…Computational systems biology analyses typically make use of multiple software and their dependencies, which are often run across heterogeneous compute…”
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MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery by Wooten, David J., Meyer, Christian T., Lubbock, Alexander L. R., Quaranta, Vito, Lopez, Carlos F.

“…Drug combination discovery depends on reliable synergy metrics but no consensus exists on the correct synergy criterion to characterize combined interactions…”
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Accredit scientific software for sustainability by Lubbock, Alexander L. R.

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SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships by Wappett, Mark, Harris, Adam, Lubbock, Alexander L R, Lobb, Ian, McDade, Simon, Overton, Ian M

“…Abstract Achilles’ heel relationships arise when the status of one gene exposes a cell's vulnerability to perturbation of a second gene, such as chemical…”
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Thunor: visualization and analysis of high-throughput dose–response datasets by Lubbock, Alexander L R, Harris, Leonard A, Quaranta, Vito, Tyson, Darren R, Lopez, Carlos F

“…Abstract High-throughput cell proliferation assays to quantify drug-response are becoming increasingly common and powerful with the emergence of improved…”
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GPU-powered model analysis with PySB/cupSODA by Harris, Leonard A, Nobile, Marco S, Pino, James C, Lubbock, Alexander L R, Besozzi, Daniela, Mauri, Giancarlo, Cazzaniga, Paolo, Lopez, Carlos F

“…A major barrier to the practical utilization of large, complex models of biochemical systems is the lack of open-source computational tools to evaluate model…”
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The effects of bolt length on penetration hole characteristics, brain damage and specified-risk material dispersal in finished cattle stunned with a penetrating captive bolt stunner by Wagner, D.R., Kline, H.C., Martin, M.S., Alexander, L.R., Grandin, T., Edwards-Callaway, L.N.

“…The purpose of this study was to determine the effect of captive bolt lengths on penetration hole characteristics, brain damage, and specified risk material…”
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Programmatic modeling for biological systems by Lubbock, Alexander L.R., Lopez, Carlos F.

“…Computational modeling has become an established technique to encode mathematical representations of cellular processes and gain mechanistic insights that…”
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Sunitinib Treatment Exacerbates Intratumoral Heterogeneity in Metastatic Renal Cancer by Stewart, Grant D, O'Mahony, Fiach C, Laird, Alexander, Eory, Lel, Lubbock, Alexander L R, Mackay, Alan, Nanda, Jyoti, O'Donnell, Marie, Mullen, Peter, McNeill, S Alan, Riddick, Antony C P, Berney, Daniel, Bex, Axel, Aitchison, Michael, Overton, Ian M, Harrison, David J, Powles, Thomas

“…The aim of this study was to investigate the effect of VEGF-targeted therapy (sunitinib) on molecular intratumoral heterogeneity (ITH) in metastatic clear cell…”
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Family history of cancer in first degree relatives and risk of cancer of unknown primary by Grewcock, Alexander L. R., Hermans, Karlijn E. P. E., Weijenberg, Matty P., Brandt, Piet A., Loef, Caroline, Jansen, Rob L. H., Schouten, Leo J.

“…Objective Cancer of Unknown Primary (CUP) refers to the presence of metastatic lesions, with no identifiable primary site during the patient's lifetime. Poor…”
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TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data by Lubbock, Alexander L R, Katz, Elad, Harrison, David J, Overton, Ian M

“…Tissue microarrays (TMAs) allow multiplexed analysis of tissue samples and are frequently used to estimate biomarker protein expression in tumour biopsies. TMA…”
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Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation by Ramsey, Haley E., Stengel, Kristy, Pino, James C., Johnston, Gretchen, Childress, Merrida, Gorska, Agnieszka E., Arrate, Pia M., Fuller, Londa, Villaume, Matthew, Fischer, Melissa A., Ferrell, P. Brent, Roe, Caroline E., Zou, Jing, Lubbock, Alexander L. R., Stubbs, Matthew, Zinkel, Sandra, Irish, Jonathan M., Lopez, Carlos F., Hiebert, Scott, Savona, Michael R.

“…Background All-trans retinoic acid (ATRA), a derivate of vitamin A, has been successfully used as a therapy to induce differentiation in M3 acute promyelocytic…”
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Overcoming intratumoural heterogeneity for reproducible molecular risk stratification: a case study in advanced kidney cancer by Lubbock, Alexander L R, Stewart, Grant D, O'Mahony, Fiach C, Laird, Alexander, Mullen, Peter, O'Donnell, Marie, Powles, Thomas, Harrison, David J, Overton, Ian M

“…Metastatic clear cell renal cell cancer (mccRCC) portends a poor prognosis and urgently requires better clinical tools for prognostication as well as for…”
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ACDC: Automated Cell Detection and Counting for Time-Lapse Fluorescence Microscopy by Rundo, Leonardo, Tangherloni, Andrea, Tyson, Darren R., Betta, Riccardo, Militello, Carmelo, Spolaor, Simone, Nobile, Marco S., Besozzi, Daniela, Lubbock, Alexander L. R., Quaranta, Vito, Mauri, Giancarlo, Lopez, Carlos F., Cazzaniga, Paolo

“…Advances in microscopy imaging technologies have enabled the visualization of live-cell dynamic processes using time-lapse microscopy imaging. However, modern…”
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Executive summary of the 2000 US regional transmission organization study by Alexander, L.R., Abe, J., Clark, C.

“…Over the past year, the future makeup of the US electric transmission industry has become better defined, although a number of unresolved issues still remain…”
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Computer Availability and Principals' Perceptions of Online Surveys by Eaton, Danice K., Brener, Nancy D., Kann, Laura, Roberts, Alice M., Kyle, Tonja M., Flint, Katherine H., Ross, Alexander L. R.

“…BACKGROUND: School‐based risk behavior surveys traditionally have been administered via paper‐and‐pencil. This study assessed the feasibility of conducting…”
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