Search Results - "Alexander, Kylie A"

Fracture Healing via Periosteal Callus Formation Requires Macrophages for Both Initiation and Progression of Early Endochondral Ossification by Raggatt, Liza J, Wullschleger, Martin E, Alexander, Kylie A, Wu, Andy C.K, Millard, Susan M, Kaur, Simranpreet, Maugham, Michelle L, Gregory, Laura S, Steck, Roland, Pettit, Allison R

“…The distribution, phenotype, and requirement of macrophages for fracture-associated inflammation and/or early anabolic progression during endochondral callus…”
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Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model by Alexander, Kylie A, Chang, Ming K, Maylin, Erin R, Kohler, Thomas, Müller, Ralph, Wu, Andy C, Van Rooijen, Nico, Sweet, Matthew J, Hume, David A, Raggatt, Liza J, Pettit, Allison R

“…Bone‐lining tissues contain a population of resident macrophages termed osteomacs that interact with osteoblasts in vivo and control mineralization in vitro…”
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Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo by Chang, Ming K, Raggatt, Liza-Jane, Alexander, Kylie A, Kuliwaba, Julia S, Fazzalari, Nicola L, Schroder, Kate, Maylin, Erin R, Ripoll, Vera M, Hume, David A, Pettit, Allison R

“…Resident macrophages are an integral component of many tissues and are important in homeostasis and repair. This study examines the contribution of resident…”
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Oncostatin M regulates hematopoietic stem cell (HSC) niches in the bone marrow to restrict HSC mobilization by Bisht, Kavita, McGirr, Crystal, Lee, Seo-Youn, Tseng, Hsu-Wen, Fleming, Whitney, Alexander, Kylie A., Matsumoto, Taichi, Barbier, Valérie, Sims, Natalie A., Müller-Newen, Gerhard, Winkler, Ingrid G., Bonig, Halvard, Lévesque, Jean-Pierre

“…We show that pro-inflammatory oncostatin M (OSM) is an important regulator of hematopoietic stem cell (HSC) niches in the bone marrow (BM). Treatment of…”
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Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease by Flynn, Ryan, Allen, Jessica L., Luznik, Leo, MacDonald, Kelli P., Paz, Katelyn, Alexander, Kylie A., Vulic, Ante, Du, Jing, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Poe, Jonathan C., Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Maillard, Ivan, Koreth, John, Cutler, Corey S., Soiffer, Robert J., Antin, Joseph H., Ritz, Jerome, Chao, Nelson J., Clynes, Raphael A., Sarantopoulos, Stefanie, Blazar, Bruce R.

“…Novel therapies for chronic graft-versus-host disease (cGVHD) are needed. Aberrant B-cell activation has been demonstrated in mice and humans with cGVHD…”
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Inhibition of JAK1/2 Tyrosine Kinases Reduces Neurogenic Heterotopic Ossification After Spinal Cord Injury by Alexander, Kylie A, Tseng, Hsu-Wen, Fleming, Whitney, Jose, Beulah, Salga, Marjorie, Kulina, Irina, Millard, Susan M, Pettit, Allison R, Genêt, François, Levesque, Jean-Pierre

“…Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of traumatic brain and spinal cord injuries (SCI) which manifest as abnormal…”
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Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation by Varelias, Antiopi, Gartlan, Kate H., Kreijveld, Ellen, Olver, Stuart D., Lor, Mary, Kuns, Rachel D., Lineburg, Katie E., Teal, Bianca E., Raffelt, Neil C., Cheong, Melody, Alexander, Kylie A., Koyama, Motoko, Markey, Kate A., Sturgeon, Elise, Leach, Justine, Reddy, Pavan, Kennedy, Glen A., Yanik, Gregory A., Blazar, Bruce R., Tey, Siok-Keen, Clouston, Andrew D., MacDonald, Kelli P.A., Cooke, Kenneth R., Hill, Geoffrey R.

“…Idiopathic pneumonia syndrome (IPS) is a relatively common, frequently fatal clinical entity, characterized by noninfectious acute lung inflammation following…”
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Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications by Torossian, Frédéric, Guerton, Bernadette, Anginot, Adrienne, Alexander, Kylie A, Desterke, Christophe, Soave, Sabrina, Tseng, Hsu-Wen, Arouche, Nassim, Boutin, Laetitia, Kulina, Irina, Salga, Marjorie, Jose, Beulah, Pettit, Allison R, Clay, Denis, Rochet, Nathalie, Vlachos, Erica, Genet, Guillaume, Debaud, Charlotte, Denormandie, Philippe, Genet, François, Sims, Natalie A, Banzet, Sébastien, Levesque, Jean-Pierre, Lataillade, Jean-Jacques, Le Bousse-Kerdilès, Marie-Caroline

“…Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in muscles surrounding joints following spinal cord or brain injury. We…”
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Promoting regulation via the inhibition of DNAM-1 after transplantation by Koyama, Motoko, Kuns, Rachel D., Olver, Stuart D., Lineburg, Katie E., Lor, Mary, Teal, Bianca E., Raffelt, Neil C., Leveque, Lucie, Chan, Christopher J., Robb, Renee J., Markey, Kate A., Alexander, Kylie A., Varelias, Antiopi, Clouston, Andrew D., Smyth, Mark J., MacDonald, Kelli P.A., Hill, Geoffrey R.

“…Donor T cells play pivotal roles in graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects following bone marrow transplantation (BMT). DNAX…”
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Lymphocytes Are Not Required for Neurogenic Heterotopic Ossification Development after Spinal Cord Injury by Alexander, Kylie A, Tseng, Hsu-Wen, Kulina, Irina, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Ruitenberg, Marc J, Lévesque, Jean-Pierre

“…Neurogenic heterotopic ossifications (NHOs) are incapacitating complications of traumatic brain and spinal cord injuries (SCI) that manifest as abnormal bone…”
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Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles by Tseng, Hsu-Wen, Girard, Dorothée, Alexander, Kylie A, Millard, Susan M, Torossian, Frédéric, Anginot, Adrienne, Fleming, Whitney, Gueguen, Jules, Goriot, Marie-Emmanuelle, Clay, Denis, Jose, Beulah, Nowlan, Bianca, Pettit, Allison R, Salga, Marjorie, Genêt, François, Bousse-Kerdilès, Marie-Caroline Le, Banzet, Sébastien, Lévesque, Jean-Pierre

“…The cells of origin of neurogenic heterotopic ossifications (NHOs), which develop frequently in the periarticular muscles following spinal cord injuries (SCIs)…”
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Neurogenic Heterotopic Ossifications Recapitulate Hematopoietic Stem Cell Niche Development Within an Adult Osteogenic Muscle Environment by Girard, Dorothée, Torossian, Frédéric, Oberlin, Estelle, Alexander, Kylie A, Gueguen, Jules, Tseng, Hsu-Wen, Genêt, François, Lataillade, Jean-Jacques, Salga, Marjorie, Levesque, Jean-Pierre, Le Bousse-Kerdilès, Marie-Caroline, Banzet, Sébastien

“…Hematopoiesis and bone interact in various developmental and pathological processes. Neurogenic heterotopic ossifications (NHO) are the formation of ectopic…”
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Expression of Gal4-dependent transgenes in cells of the mononuclear phagocyte system labeled with enhanced cyan fluorescent protein using Csf1r-Gal4VP16/UAS-ECFP double-transgenic mice by Ovchinnikov, Dmitry A., Zuylen, Wendy J. M., DeBats, Claire E. E., Alexander, Kylie A., Kellie, Stuart, Hume, David A.

“…We generated double‐transgenic mice carrying cointegrated tissue‐specific Gal4 and Gal4 reporter transgenes to direct transgene overexpression in the…”
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Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs by Winkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico, Alexander, Kylie A., Raggatt, Liza J., Lévesque, Jean-Pierre

“…In the bone marrow, hematopoietic stem cells (HSCs) reside in specific niches near osteoblast-lineage cells at the endosteum. To investigate the regulation of…”
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Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production by Du, Jing, Paz, Katelyn, Flynn, Ryan, Vulic, Ante, Robinson, Tara M., Lineburg, Katie E., Alexander, Kylie A., Meng, Jingjing, Roy, Sabita, Panoskaltsis-Mortari, Angela, Loschi, Michael, Hill, Geoffrey R., Serody, Jonathan S., Maillard, Ivan, Miklos, David, Koreth, John, Cutler, Corey S., Antin, Joseph H., Ritz, Jerome, MacDonald, Kelli P., Schacker, Timothy W., Luznik, Leo, Blazar, Bruce R.

“…Allogeneic hematopoietic stem cell transplantation is hampered by chronic graft-versus-host disease (cGVHD), resulting in multiorgan fibrosis and diminished…”
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CSF-1-dependant donor-derived macrophages mediate chronic graft-versus-host disease by Alexander, Kylie A, Flynn, Ryan, Lineburg, Katie E, Kuns, Rachel D, Teal, Bianca E, Olver, Stuart D, Lor, Mary, Raffelt, Neil C, Koyama, Motoko, Leveque, Lucie, Le Texier, Laetitia, Melino, Michelle, Markey, Kate A, Varelias, Antiopi, Engwerda, Christian, Serody, Jonathan S, Janela, Baptiste, Ginhoux, Florent, Clouston, Andrew D, Blazar, Bruce R, Hill, Geoffrey R, MacDonald, Kelli P A

“…Chronic GVHD (cGVHD) is the major cause of late, nonrelapse death following stem cell transplantation and characteristically develops in organs such as skin…”
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Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease by Tseng, Hsu-Wen, Samuel, Selwin Gabriel, Schroder, Kate, Lévesque, Jean-Pierre, Alexander, Kylie A

“…Purpose of Review Inflammasomes are multimeric protein structures with crucial roles in host responses against infections and injuries. The importance of…”
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Interleukin‐1 Is Overexpressed in Injured Muscles Following Spinal Cord Injury and Promotes Neurogenic Heterotopic Ossification by Tseng, Hsu‐Wen, Kulina, Irina, Girard, Dorothée, Gueguen, Jules, Vaquette, Cedryck, Salga, Marjorie, Fleming, Whitney, Jose, Beulah, Millard, Susan M, Pettit, Allison R, Schroder, Kate, Thomas, Gethin, Wheeler, Lawrie, Genêt, François, Banzet, Sébastien, Alexander, Kylie A, Lévesque, Jean‐Pierre

“…ABSTRACT Neurogenic heterotopic ossifications (NHOs) form in periarticular muscles after severe spinal cord (SCI) and traumatic brain injuries. The…”
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Neurogenic Heterotopic Ossifications Develop Independently of Granulocyte Colony‐Stimulating Factor and Neutrophils by Tseng, Hsu‐Wen, Kulina, Irina, Salga, Marjorie, Fleming, Whitney, Vaquette, Cedryck, Genêt, François, Levesque, Jean‐Pierre, Alexander, Kylie A

“…ABSTRACT Neurogenic heterotopic ossifications (NHOs) are incapacitating heterotopic bones in periarticular muscles that frequently develop following traumatic…”
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When the Nervous System Turns Skeletal Muscles into Bones: How to Solve the Conundrum of Neurogenic Heterotopic Ossification by Alexander, Kylie A., Tseng, Hsu-Wen, Salga, Marjorie, Genêt, François, Levesque, Jean-Pierre

“…Purpose of Review Neurogenic heterotopic ossification (NHO) is the abnormal formation of extra-skeletal bones in periarticular muscles after damage to the…”
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