Search Results - "Alexander, Jeffrey M"

Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity by Alexander, Jeffrey M, Guan, Juan, Li, Bingkun, Maliskova, Lenka, Song, Michael, Shen, Yin, Huang, Bo, Lomvardas, Stavros, Weiner, Orion D

“…Enhancers are important regulatory elements that can control gene activity across vast genetic distances. However, the underlying nature of this regulation…”
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Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage by Wamstad, Joseph A, Alexander, Jeffrey M, Truty, Rebecca M, Shrikumar, Avanti, Li, Fugen, Eilertson, Kirsten E, Ding, Huiming, Wylie, John N, Pico, Alexander R, Capra, John A, Erwin, Genevieve, Kattman, Steven J, Keller, Gordon M, Srivastava, Deepak, Levine, Stuart S, Pollard, Katherine S, Holloway, Alisha K, Boyer, Laurie A, Bruneau, Benoit G

“…Heart development is exquisitely sensitive to the precise temporal regulation of thousands of genes that govern developmental decisions during differentiation…”
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Brg1 modulates enhancer activation in mesoderm lineage commitment by Alexander, Jeffrey M, Hota, Swetansu K, He, Daniel, Thomas, Sean, Ho, Lena, Pennacchio, Len A, Bruneau, Benoit G

“…The interplay between different levels of gene regulation in modulating developmental transcriptional programs, such as histone modifications and chromatin…”
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In pursuit of smart growth: technology transfer theories, policies and practices by Carayannis, Elias G., Grigoroudis, Evangelos, Alexander, Jeffrey M.

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Chromatin remodelling complex dosage modulates transcription factor function in heart development by Bruneau, Benoit G, Takeuchi, Jun K, Lou, Xin, Alexander, Jeffrey M, Sugizaki, Hiroe, Delgado-Olguín, Paul, Holloway, Alisha K, Mori, Alessandro D, Wylie, John N, Munson, Chantilly, Zhu, Yonghong, Zhou, Yu-Qing, Yeh, Ru-Fang, Henkelman, R. Mark, Harvey, Richard P, Metzger, Daniel, Chambon, Pierre, Stainier, Didier Y. R, Pollard, Katherine S, Scott, Ian C

“…Dominant mutations in cardiac transcription factor genes cause human inherited congenital heart defects (CHDs); however, their molecular basis is not…”
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IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies by Leborgne, Christian, Barbon, Elena, Alexander, Jeffrey M., Hanby, Hayley, Delignat, Sandrine, Cohen, Daniel M., Collaud, Fanny, Muraleetharan, Saghana, Lupo, Dan, Silverberg, Joseph, Huang, Karen, van Wittengerghe, Laetitia, Marolleau, Béatrice, Miranda, Adeline, Fabiano, Anna, Daventure, Victoria, Beck, Heena, Anguela, Xavier M., Ronzitti, Giuseppe, Armour, Sean M., Lacroix-Desmazes, Sebastien, Mingozzi, Federico

“…Neutralizing antibodies to adeno-associated virus (AAV) vectors are highly prevalent in humans 1 , 2 , and block liver transduction 3 – 5 and vector…”
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Lessons for cardiac regeneration and repair through development by Alexander, Jeffrey M, Bruneau, Benoit G

“…Cell-based regenerative strategies have the potential to revolutionize the way cardiovascular injury is treated, but successful therapies will require a…”
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Insights into nuclear dynamics using live‐cell imaging approaches by Bigley, Rachel B., Payumo, Alexander Y., Alexander, Jeffrey M., Huang, Guo N.

“…The nucleus contains the genetic blueprint of the cell and myriad interactions within this subcellular structure are required for gene regulation. In the…”
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IdeS: An enabling technology to overcome the limitation of neutralizing antibodies to AAV gene therapy by Alexander, Jeffrey M., Hanby, Hayley, Lupo, Daniel, Muraleetharan, Saghana, Rizzo, Christopher, Cohen, Daniel M., Silverberg, Joseph, Beck, Heena, Anguela, Xavier, Armour, Sean M., Mingozzi, Federico

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Nuclear architecture as an epigenetic regulator of neural development and function by Alexander, J.M, Lomvardas, S

“…Highlights • The nucleus is non-randomly organized into compartments and domains that impact genome function. • Regulation of nuclear architecture accompanies…”
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IgG-cleaving endopeptidase enables in vivo gene therapy in the presence of anti-AAV neutralizing antibodies by Leborgne, Christian, Barbon, Elena, Alexander, Jeffrey, Hanby, Hayley, Delignat, Sandrine, Cohen, Daniel, Collaud, Fanny, Muraleetharan, Saghana, Lupo, Dan, Silverberg, Joseph, Huang, Karen, van Wittengerghe, Laetitia, Marolleau, Béatrice, Miranda, Adeline, Fabiano, Anna, Daventure, Victoria, Beck, Heena, Anguela, Xavier, Ronzitti, Giuseppe, Armour, Sean, Lacroix-Desmazes, Sebastien, Mingozzi, Federico

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Stage-specific Chromatin Modification and Regulation in Cardiomyocyte Differentiation by Alexander, Jeffrey M

“…Development of a properly formed heart is vital to life and defects in cardiogenesis lead to congenital heart disease. Central to this process is the…”
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A Value Assessment Engine for the International Space Station Program by Alexander, Jeffrey M., Anderson, Benjamin J., Hilscher, Rainer, Sykes, Alison, Witsil, Amy

“…The International Space Station (ISS) Program at NASA's Johnson Space Center commissioned RTI International to develop a system for identifying, tracking, and…”
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Steroid Treatment of Eosinophilic Esophagitis in Adults by Alexander, Jeffrey A., MD

“…Topical steroid therapy has been used to treat eosinophilic esophagitis (EoE) for more than 15 years. We review the treatment trials of topical steroid therapy…”
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Occurrence of and risk factors for complications after endoscopic dilation in eosinophilic esophagitis by Jung, Kee Wook, MD, Gundersen, Nancy, MD, Kopacova, Jana, Arora, Amindra S., MB, BChir, Romero, Yvonne, MD, Katzka, David, MD, Francis, Dawn, MD, MHS, Schreiber, Julie, Dierkhising, Ross A., MS, Talley, Nicholas J., MD, PhD, Smyrk, Thomas C., MD, SgPa, Alexander, Jeffrey A., MD

“…Background Several small series have suggested an increased risk of complications associated with esophageal dilation in patients with eosinophilic esophagitis…”
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H influenzae LPS colocalization with Toll-like receptor 4 in eosinophilic esophagitis by Ravi, Anupama, Marietta, Eric V., Alexander, Jeffrey A., Murray, Joseph A., Katzka, David A.

“…Patients with eosinophilic esophagitis (EoE) have a unique esophageal microbiome with increased presence of Haemophilus influenzae, but its role in the disease…”
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Eosinophilic esophagitis: search for noninvasive techniques for long-term monitoring by Watts, Abhishek, MD, Alexander, Jeffrey A., MD, Gupta, Sandeep K., MD

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Training in small-bowel capsule endoscopy: assessing and defining competency by Rajan, Elizabeth, MD, Iyer, Prasad G., MD, Oxentenko, Amy S., MD, Pardi, Darrell S., MD, Alexander, Jeffrey A., MD, Baron, Todd H., MD, Bruining, David H., MD, Hansel, Stephanie L., MD, Larson, Mark V., MD, Murray, Joseph A., MD, DeBritto, John, Dierkhising, Ross A., MS, Gostout, Christopher J., MD

“…Background Minimum training for capsule endoscopy (CE) is based on societal guidelines and expert opinion. Objective measures of competence are lacking…”
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Double-balloon enteroscopy as a rescue technique for failed direct percutaneous endoscopic jejunostomy when using conventional push enteroscopy (with video) by Wong Kee Song, Louis M., MD, Baron, Todd H., MD, FASGE, Saleem, Atif, MD, Bruining, David H., MD, Alexander, Jeffrey A., MD, Rajan, Elizabeth, MD

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Eosinophilic Esophagitis: It Is Here to Stay by Alexander, Jeffrey A., MD, Katzka, David A., MD

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