Search Results - "Alexander, Jeff"

Differential Synergistic Interactions Among Four Different Wheat-Infecting Viruses by Tatineni, Satyanarayana, Alexander, Jeff, Qu, Feng

“…Field-grown wheat ( L.) plants can be co-infected by multiple viruses, including wheat streak mosaic virus (WSMV), Triticum mosaic virus (TriMV), brome mosaic…”
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saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern by Komori, Mai, Nogimori, Takuto, Morey, Amber L., Sekida, Takashi, Ishimoto, Keiko, Hassett, Matthew R., Masuta, Yuji, Ode, Hirotaka, Tamura, Tomokazu, Suzuki, Rigel, Alexander, Jeff, Kido, Yasutoshi, Matsuda, Kenta, Fukuhara, Takasuke, Iwatani, Yasumasa, Yamamoto, Takuya, Smith, Jonathan F., Akahata, Wataru

“…Several vaccines have been widely used to counteract the global pandemic caused by SARS-CoV-2. However, due to the rapid emergence of SARS-CoV-2 variants of…”
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Safety and immunogenicity of an oral, replicating adenovirus serotype 4 vector vaccine for H5N1 influenza: a randomised, double-blind, placebo-controlled, phase 1 study by Gurwith, Marc, Dr, Lock, Michael, PhD, Taylor, Eve M, PhD, Ishioka, Glenn, PhD, Alexander, Jeff, PhD, Mayall, Tim, PhD, Ervin, John E, MD, Greenberg, Richard N, Prof, Strout, Cynthia, MD, Treanor, John J, Prof, Webby, Richard, PhD, Wright, Peter F, Prof

“…Summary Background Replication-competent virus vector vaccines might have advantages compared with non-replicating vector vaccines. We tested the safety and…”
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Differential V2-directed antibody responses in non-human primates infected with SHIVs or immunized with diverse HIV vaccines by Weiss, Svenja, Itri, Vincenza, Pan, Ruimin, Jiang, Xunqing, Luo, Christina C., Morris, Lynn, Malherbe, Delphine C., Barnette, Philip, Alexander, Jeff, Kong, Xiang-Peng, Haigwood, Nancy L., Hessell, Ann J., Duerr, Ralf, Zolla-Pazner, Susan

“…V2p and V2i antibodies (Abs) that are specific for epitopes in the V1V2 region of the HIV gp120 envelope (Env) do not effectively neutralize HIV but mediate…”
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Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans by ASSARSSON, Erika, BUI, Huynh-Hoa, SETTE, Alessandro, SIDNEY, John, QING ZHANG, GLENN, Jean, OSEROFF, Carla, MBAWUIKE, Innocent N, ALEXANDER, Jeff, NEWMAN, Mark J, GREY, Howard

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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms by Riley, Brigit E, Gardai, Shyra J, Emig-Agius, Dorothea, Bessarabova, Marina, Ivliev, Alexander E, Schüle, Birgitt, Schüle, Birgit, Alexander, Jeff, Wallace, William, Halliday, Glenda M, Langston, J William, Braxton, Scott, Yednock, Ted, Shaler, Thomas, Johnston, Jennifer A

“…Detailed analysis of disease-affected tissue provides insight into molecular mechanisms contributing to pathogenesis. Substantia nigra, striatum, and cortex…”
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Zika virus-like particle vaccine protects AG129 mice and rhesus macaques against Zika virus by Vang, Lo, Morello, Christopher S, Mendy, Jason, Thompson, Danielle, Manayani, Darly, Guenther, Ben, Julander, Justin, Sanford, Daniel, Jain, Amit, Patel, Amish, Shabram, Paul, Smith, Jonathan, Alexander, Jeff

“…Zika virus (ZIKV), a mosquito-borne flavivirus, is a re-emerging virus that constitutes a public health threat due to its recent global spread, recurrent…”
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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease by Gardai, Shyra J, Mao, Wenxian, Schüle, Birgitt, Babcock, Michael, Schoebel, Sue, Lorenzana, Carlos, Alexander, Jeff, Kim, Sam, Glick, Heather, Hilton, Kathryn, Fitzgerald, J Kent, Buttini, Manuel, Chiou, San-San, McConlogue, Lisa, Anderson, John P, Schenk, Dale B, Bard, Frederique, Langston, J William, Yednock, Ted, Johnston, Jennifer A

“…Alpha-synuclein protein is strongly implicated in the pathogenesis Parkinson's disease. Increased expression of α-synuclein due to genetic multiplication or…”
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Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge by Thompson, Danielle, Guenther, Ben, Manayani, Darly, Mendy, Jason, Smith, Jonathan, Espinosa, Diego A, Harris, Eva, Alexander, Jeff, Vang, Lo, Morello, Christopher S

“…Zika virus (ZIKV) is a mosquito-borne flavivirus with maternal infection associated with preterm birth, congenital malformations, and fetal death, and adult…”
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Passive Transfer of Immune Sera Induced by a Zika Virus-Like Particle Vaccine Protects AG129 Mice Against Lethal Zika Virus Challenge by Espinosa, Diego, Mendy, Jason, Manayani, Darly, Vang, Lo, Wang, Chunling, Richard, Tiffany, Guenther, Ben, Aruri, Jayavani, Avanzini, Jenny, Garduno, Fermin, Farness, Peggy, Gurwith, Marc, Smith, Jon, Harris, Eva, Alexander, Jeff

“…Zika virus (ZIKV) poses a serious public health threat due to its association with birth defects in developing fetuses and Guillain-Barré Syndrome in adults…”
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Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin by Alexander, Jeff, Ward, Simone, Mendy, Jason, Manayani, Darly J, Farness, Peggy, Avanzini, Jenny B, Guenther, Ben, Garduno, Fermin, Jow, Lily, Snarsky, Victoria, Ishioka, Glenn, Dong, Xin, Vang, Lo, Newman, Mark J, Mayall, Tim

“…Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a…”
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Oral priming with replicating adenovirus serotype 4 followed by subunit H5N1 vaccine boost promotes antibody affinity maturation and expands H5N1 cross-clade neutralization by Khurana, Surender, Coyle, Elizabeth M, Manischewitz, Jody, King, Lisa R, Ishioka, Glenn, Alexander, Jeff, Smith, Jon, Gurwith, Marc, Golding, Hana

“…A Phase I trial conducted in 2009-2010 demonstrated that oral vaccination with a replication competent Ad4-H5 (A/Vietnam) vector with dosages ranging from…”
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Modified Adenovirus Prime-Protein Boost Clade C HIV Vaccine Strategy Results in Reduced Viral DNA in Blood and Tissues Following Tier 2 SHIV Challenge by Malherbe, Delphine C, Vang, Lo, Mendy, Jason, Barnette, Philip T, Spencer, David A, Reed, Jason, Kareko, Bettie W, Sather, D Noah, Pandey, Shilpi, Wibmer, Constantinos K, Robins, Harlan, Fuller, Deborah H, Park, Byung, Lakhashe, Samir K, Wilson, James M, Axthelm, Michael K, Ruprecht, Ruth M, Moore, Penny L, Sacha, Jonah B, Hessell, Ann J, Alexander, Jeff, Haigwood, Nancy L

“…Designing immunogens and improving delivery methods eliciting protective immunity is a paramount goal of HIV vaccine development. A comparative vaccine…”
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Cellular immune response to cryptic epitopes during therapeutic gene transfer by Li, Chengwen, Goudy, Kevin, Hirsch, Matt, Asokan, Aravind, Fan, Yun, Alexander, Jeff, Sun, Junjiang, Monahan, Paul, Seiber, David, Sidney, John, Sette, Alessandro, Tisch, Roland, Frelinger, Jeff, Samulski, R. Jude

“…The immune response has been implicated as a critical factor in determining the success or failure of clinical gene therapy trials. Generally, such a response…”
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Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine by Matsuda, Kenta, Huang, Jinghe, Zhou, Tongqing, Sheng, Zizhang, Kang, Byong H, Ishida, Elise, Griesman, Trevor, Stuccio, Sarah, Bolkhovitinov, Lyuba, Wohlbold, Teddy J, Chromikova, Veronika, Cagigi, Alberto, Leung, Kwanyee, Andrews, Sarah, Cheung, Crystal S F, Pullano, Alyssa A, Plyler, Jason, Soto, Cinque, Zhang, Baoshan, Yang, Yongping, Joyce, M Gordon, Tsybovsky, Yaroslav, Wheatley, Adam, Narpala, Sandeep R, Guo, Yicheng, Darko, Sam, Bailer, Robert T, Poole, April, Liang, C Jason, Smith, Jon, Alexander, Jeff, Gurwith, Marc, Migueles, Stephen A, Koup, Richard A, Golding, Hana, Khurana, Surender, McDermott, Adrian B, Shapiro, Lawrence, Krammer, Florian, Kwong, Peter D, Connors, Mark

“…Induction of an antibody response capable of recognizing highly diverse strains is a major obstacle to the development of vaccines for viruses such as HIV and…”
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CD4 + T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword by El Bissati, Kamal, Krishack, Paulette A, Zhou, Ying, Weber, Christopher R, Lykins, Joseph, Jankovic, Dragana, Edelblum, Karen L, Fraczek, Laura, Grover, Harshita, Chentoufi, Aziz A, Singh, Gurminder, Reardon, Catherine, Dubey, J P, Reed, Steve, Alexander, Jeff, Sidney, John, Sette, Alessandro, Shastri, Nilabh, McLeod, Rima

“…CD4 T cells have been found to play critical roles in the control of both acute and chronic infection. Previous studies identified a protective role for the…”
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Pre-clinical development of a recombinant, replication-competent adenovirus serotype 4 vector vaccine expressing HIV-1 envelope 1086 clade C by Alexander, Jeff, Mendy, Jason, Vang, Lo, Avanzini, Jenny B, Garduno, Fermin, Manayani, Darly J, Ishioka, Glenn, Farness, Peggy, Ping, Li-Hua, Swanstrom, Ronald, Parks, Robert, Liao, Hua-Xin, Haynes, Barton F, Montefiori, David C, LaBranche, Celia, Smith, Jonathan, Gurwith, Marc, Mayall, Tim

“…There is a well-acknowledged need for an effective AIDS vaccine that protects against HIV-1 infection or limits in vivo viral replication. The objective of…”
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Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus by Alexander, Jeff, Bilsel, Pamuk, del Guercio, Marie-France, Marinkovic-Petrovic, Aleksandra, Southwood, Scott, Stewart, Stephani, Ishioka, Glenn, Kotturi, Maya F, Botten, Jason, Sidney, John, Newman, Mark, Sette, Alessandro

“…Abstract Influenza virus remains a significant health concern, with current circulating strains that affect millions each year plus the threat of newly…”
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A Multivalent Vaccination Strategy for the Prevention of Old World Arenavirus Infection in Humans by BOTTEN, Jason, LINDSAY WHITTON, J, BARROWMAN, Polly, SIDNEY, John, WHITMIRE, Jason K, ALEXANDER, Jeff, KOTTURI, Maya F, SETTE, Alessandro, BUCHMEIER, Michael J

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease by Kotturi, Maya F, Botten, Jason, Sidney, John, Bui, Huynh-Hoa, Giancola, Lori, Maybeno, Matt, Babin, Josie, Oseroff, Carla, Pasquetto, Valerie, Greenbaum, Jason A, Peters, Bjoern, Ting, Joey, Do, Danh, Vang, Lo, Alexander, Jeff, Grey, Howard, Buchmeier, Michael J, Sette, Alessandro

“…Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available…”
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