Search Results - "Alexander, I E"

Synthetic certified DNA reference material for analysis of human erythropoietin transgene and transcript in gene doping and gene therapy by Baoutina, A, Bhat, S, Zheng, M, Partis, L, Dobeson, M, Alexander, I E, Emslie, K R

“…There is a recognised need for standardisation of protocols for vector genome analysis used in vector manufacturing, to establish dosage, in biodistribution…”
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Bidirectional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct by Curtin, J A, Dane, A P, Swanson, A, Alexander, I E, Ginn, S L

“…Gene transfer vectors encoding two or more genes are potentially powerful research tools and are poised to play an increasingly important role in gene therapy…”
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Metaheuristics “In the Large” by Swan, Jerry, Adriaensen, Steven, Brownlee, Alexander E.I., Hammond, Kevin, Johnson, Colin G., Kheiri, Ahmed, Krawiec, Faustyna, Merelo, J.J., Minku, Leandro L., Özcan, Ender, Pappa, Gisele L., García-Sánchez, Pablo, Sörensen, Kenneth, Voß, Stefan, Wagner, Markus, White, David R.

“…Following decades of sustained improvement, metaheuristics are one of the great success stories of optimization research. However, in order for research in…”
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Comparing apples and oranges? Investigating the consistency of CPU and memory profiler results across multiple java versions by Watkinson, Myles, Brownlee, Alexander E. I.

“…Profiling is an important tool in the software developer’s box, used to identify hot methods where most computational resources are used, to focus efforts at…”
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Fibroblasts modulate cardiomyocyte excitability: implications for cardiac gene therapy by KIZANA, E, GINN, S. L, SMYTH, C. M, BOYD, A, THOMAS, S. P, ALLEN, D. G, ROSS, D. L, ALEXANDER, I. E

“…In an earlier study exploring the potential of gene transfer to repair myocardial conduction defects, we observed that myotubes, generated by forced expression…”
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A systematic approach to parameter optimization and its application to flight schedule simulation software by Brownlee, Alexander E. I., Epitropakis, Michael G., Mulder, Jeroen, Paelinck, Marc, Burke, Edmund K.

“…Industrial software often has many parameters that critically impact performance. Frequently, these are left in a sub-optimal configuration for a given…”
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Delivering efficient liver-directed AAV-mediated gene therapy by Baruteau, J, Waddington, S N, Alexander, I E, Gissen, P

“…Adeno-associated virus vectors (AAV) have become the leading technology for liver-directed gene therapy. After the pioneering trials using AAV2 and AAV8…”
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Program transformation landscapes for automated program modification using Gin by Petke, Justyna, Alexander, Brad, Barr, Earl T., Brownlee, Alexander E. I., Wagner, Markus, White, David R.

“…Automated program modification underlies two successful research areas — genetic improvement and program repair. Under the generate-and-validate strategy,…”
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Regulatory immune cells in kidney disease by Lee, V W S, Wang, Y M, Wang, Y P, Zheng, D, Polhill, T, Cao, Q, Wu, H, Alexander, I E, Alexander, S I, Harris, D C H

“…Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these…”
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Comparison of gene transfer to the murine liver following intraperitoneal and intraportal delivery of hepatotropic AAV pseudo-serotypes by Dane, A P, Wowro, S J, Cunningham, S C, Alexander, I E

“…Adeno-associated virus (AAV) vectors are highly efficient for liver-targeted gene delivery in murine models and show promise in early phase human clinical…”
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Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration by Halbert, C L, Standaert, T A, Aitken, M L, Alexander, I E, Russell, D W, Miller, A D

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Gene therapy in sport by Trent, R J, Alexander, I E

“…Experimental studies are now underway to determine the preventive effects of IGF1 in a retroviral vector given regularly by intramuscular injection. 5…”
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Potential of AAV vectors in the treatment of metabolic disease by Alexander, I E, Cunningham, S C, Logan, G J, Christodoulou, J

“…Inborn errors of metabolism are collectively common, frequently severe and in many instances difficult or impossible to treat. Accordingly, there is a…”
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Fitness Modeling With Markov Networks by Brownlee, Alexander E. I., McCall, John A. W., Qingfu Zhang

“…Fitness modeling has received growing interest from the evolutionary computation community in recent years. With a fitness model, one can improve evolutionary…”
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AAV-encoded OTC activity persisting to adulthood following delivery to newborn spfash mice is insufficient to prevent shRNA-induced hyperammonaemia by Cunningham, S C, Kok, C Y, Spinoulas, A, Carpenter, K H, Alexander, I E

“…Urea cycle defects presenting in the neonatal period with hyperammonaemia are associated with high morbidity and mortality, and necessitate liver…”
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Heuristic search for the coupled runway sequencing and taxiway routing problem by Benlic, Una, Brownlee, Alexander E.I., Burke, Edmund K.

“…•An ILS heuristic for runway sequencing and taxiway routing in continuous time.•Manchester Airport is used as a test case.•Great decrease in taxiing delay with…”
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Transient suppression of hepatocellular replication in the mouse liver following transduction with recombinant adeno-associated virus by Dane, A P, Cunningham, S C, Kok, C Y, Logan, G J, Alexander, I E

“…Recombinant vectors based on adeno-associated virus (AAV) are proving to be powerful tools for genetic manipulation of the liver, for both discovery and…”
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Gene therapy: applications and progress towards the clinic by Trent, R. J. A., Alexander, I. E.

“…Gene therapy was originally conceived as an approach to the treatment of genetic disease, to repair or replace a faulty gene. Subsequently, gene therapy…”
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Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons by Fleming, J, Ginn, S L, Weinberger, R P, Trahair, T N, Smythe, J A, Alexander, I E

“…Peripheral nervous system (PNS) sensory neurons are directly involved in the pathophysiology of numerous inherited and acquired neurological conditions…”
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An application of a GA with Markov network surrogate to feature selection by Brownlee, Alexander E.I., Regnier-Coudert, Olivier, McCall, John A.W., Massie, Stewart, Stulajter, Stefan

“…Surrogate models of fitness have been presented as a way of reducing the number of fitness evaluations required by evolutionary algorithms. This is of…”
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