Search Results - "Alexander, H G"

Pd-Catalyzed Assembly of Spirooxindole Natural Products: A Short Synthesis of Horsfiline by Deppermann, Nina, Thomanek, Heike, Prenzel, Alexander H. G. P, Maison, Wolfgang

“…The Pd-catalyzed intramolecular α-arylation of amides is applied to the synthesis of functionalized spirooxindoles. The substrate scope is evaluated, and the…”
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Risk factors for bisphosphonate-associated osteonecrosis of the jaw in the prospective randomized trial of adjuvant bisphosphonates for early-stage breast cancer (SWOG 0307) by Kizub, Darya A., Miao, Jieling, Schubert, Mark M., Paterson, Alexander H. G., Clemons, Mark, Dees, Elizabeth C., Ingle, James N., Falkson, Carla I., Barlow, William E., Hortobagyi, Gabriel N., Gralow, Julie R.

“…Purpose Bisphosphonates reduce bone metastases in postmenopausal women with early-stage breast cancer but carry the risk of bisphosphonate-related…”
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Advanced practice providers versus medical residents as leaders of rapid response teams: A 12-month retrospective analysis by Kreeftenberg, Herman G, De Bie, Ashley J. R, Mestrom, Eveline H. J, Bindels, Alexander J. G. H, van der Voort, Peter H. J

“…Purpose In a time of worldwide physician shortages, the advanced practice providers (APPs) might be a good alternative for physicians as the leaders of a rapid…”
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Randomized Active-Controlled Phase II Study of Denosumab Efficacy and Safety in Patients With Breast Cancer-Related Bone Metastases by LIPTON, Allan, STEGER, Guenther G, COLEMAN, Robert, PATERSON, Alexander H. G, PETERSON, Mark C, FAN, Michelle, KINSEY, Amy, JUN, Susie, FIGUEROA, Jazmin, ALVARADO, Cristina, SOLAL-CELIGNY, Philippe, BODY, Jean-Jacques, DE BOER, Richard, BERARDI, Rossana, GASCON, Pere, TONKIN, Katia S

“…Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor-kappaB ligand, suppresses bone resorption. In this study, we evaluated the…”
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Bone-Related Complications and Quality of Life in Advanced Breast Cancer: Results from a Randomized Phase III Trial of Denosumab versus Zoledronic Acid by MARTIN, Miguel, BELL, Richard, RITCHIE, Diana, STEGER, Gunther G, STOPECK, Alison, VOGEL, Charles, FAN, Michelle, QI JIANG, CHUNG, Karen, DANSEY, Roger, BRAUN, Ada, BOURGEOIS, Hugues, BRUFSKY, Adam, DIEL, Ingo, ENIU, Alexandru, FALLOWFIELD, Lesley, FUJIWARA, Yasuhiro, JASSEM, Jacek, PATERSON, Alexander H. G

“…Denosumab was shown to be superior to zoledronic acid in preventing skeletal related events (SRE) in patients with breast cancer and bone metastases in a…”
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Behavioral and health outcomes from the NRG Oncology/NSABP B-36 trial comparing two different adjuvant therapy regimens for early-stage node-negative breast cancer by Ganz, Patricia A., Bandos, Hanna, Geyer, Charles E., Robidoux, André, Paterson, Alexander H. G., Polikoff, Jonathan, Baez-Diaz, Luis, Brufsky, Adam M., Fehrenbacher, Louis, Parsons, Ann W., Ward, Patrick J., Provencher, Louise, Hamm, John T., Stella, Philip J., Carolla, Robert L., Margolese, Richard G., Shibata, Henry R., Perez, Edith A., Wolmark, Norman

“…Background The NSABP B-36 compared four cycles of doxorubicin and cyclophosphamide (AC) with six cycles of 5-fluorouracil, epirubicin, and cyclophosphamide…”
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Poor Prognosis After Second Locoregional Recurrences in the CALOR Trial by Wapnir, Irene L., Gelber, Shari, Anderson, Stewart J., Mamounas, Eleftherios P., Robidoux, André, Martín, Miguel, Nortier, Johan W. R., Geyer, Charles E., Paterson, Alexander H. G., Láng, István, Price, Karen N., Coates, Alan S., Gelber, Richard D., Rastogi, Priya, Regan, Meredith M., Wolmark, Norman, Aebi, Stefan

“…Background Isolated locoregional recurrences (ILRRs) of breast cancer confer a significant risk for the development of distant metastasis. Management practices…”
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Extended Efficacy and Safety of Denosumab in Breast Cancer Patients with Bone Metastases Not Receiving Prior Bisphosphonate Therapy by Allan Lipton, Guenther G. Steger, Jazmin Figueroa, Cristina Alvarado, Philippe Solal-Celigny, Jean Jacques Body, Richard de Boer, Rossana Berardi, Pere Gascon, Katia S. Tonkin, Robert E. Coleman, Alexander H.G. Paterson, Guozhi M. Gao, Amy C. Kinsey, Mark C. Peterson, Susie Jun

“…Purpose: Denosumab, a fully human monoclonal antibody to RANKL, suppresses bone resorption. This study evaluated the effects of denosumab in i.v…”
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Effect of Automated Closed-loop ventilation versus convenTional VEntilation on duration and quality of ventilation in critically ill patients (ACTiVE) - study protocol of a randomized clinical trial by Botta, Michela, Tsonas, Anissa M, Sinnige, Jante S, De Bie, Ashley J R, Bindels, Alexander J G H, Ball, Lorenzo, Battaglini, Denise, Brunetti, Iole, Buiteman-Kruizinga, Laura A, van der Heiden, Pim L J, de Jonge, Evert, Mojoli, Francesco, Robba, Chiara, Schoe, Abraham, Paulus, Frederique, Pelosi, Paolo, Neto, Ary Serpa, Horn, Janneke, Schultz, Marcus J

“…INTELLiVENT-Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of ventilation for use in critically ill patients. Evidence for benefit of…”
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The Breast Cancer to Bone (B2B) Metastases Research Program: a multi-disciplinary investigation of bone metastases from breast cancer by Brockton, Nigel T, Gill, Stephanie J, Laborge, Stephanie L, Paterson, Alexander H G, Cook, Linda S, Vogel, Hans J, Shemanko, Carrie S, Hanley, David A, Magliocco, Anthony M, Friedenreich, Christine M

“…Bone is the most common site of breast cancer distant metastasis, affecting 50-70 % of patients who develop metastatic disease. Despite decades of informative…”
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Fully automated closed-loop ventilation is safe and effective in post-cardiac surgery patients by Beijers, Ashley J. R., Roos, Arnout N., Bindels, Alexander J. G. H.

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Advanced Practice Providers as Leaders of a Rapid Response Team: A Prospective Cohort Study by Kreeftenberg, Herman G, de Bie, Ashley J R, Aarts, Jeroen T, Bindels, Alexander J G H, van der Meer, Nardo J M, van der Voort, Peter H J

“…In view of the shortage of medical staff, the quality and continuity of care may be improved by employing advanced practice providers (APPs). This study aims…”
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Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial by Paterson, Alexander HG, Prof, Anderson, Stewart J, Prof, Lembersky, Barry C, MD, Fehrenbacher, Louis, MD, Falkson, Carla I, MD, King, Karen M, MD, Weir, Lorna M, MD, Brufsky, Adam M, Prof, Dakhil, Shaker, MD, Lad, Thomas, MD, Baez-Diaz, Luis, MD, Gralow, Julie R, MD, Robidoux, André, MD, Perez, Edith A, Prof, Zheng, Ping, MD, Geyer, Charles E, MD, Swain, Sandra M, Prof, Costantino, Joseph P, Prof, Mamounas, Eleftherios P, MD, Wolmark, Norman, Prof

“…Summary Background Bisphosphonates are thought to act through the osteoclast by changing bone microenvironment. Previous findings of adjuvant clodronate trials…”
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Impact of the Advanced Practice Provider in Adult Critical Care: A Systematic Review and Meta-Analysis by Kreeftenberg, Herman G., Pouwels, Sjaak, Bindels, Alexander J. G. H., de Bie, Ashley, van der Voort, Peter H. J.

“…OBJECTIVES:To evaluate the effects on quality and efficiency of implementation of the advanced practice provider in critical care. DATA SOURCES:PubMed, Embase,…”
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Azabicycloalkenes as Synthetic Intermediates − Synthesis of Azabicyclo[X.3.0]alkane Scaffolds by Büchert, Marina, Meinke, Sebastian, Prenzel, Alexander H. G. P, Deppermann, Nina, Maison, Wolfgang

“…A general method to synthesize functionalized azabicyclo[X.3.0]alkane scaffolds 5 is reported. Key intermediates are azabicycloalkenes such as 1 and 2, which…”
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Efficacy of Chemotherapy for ER-Negative and ER-Positive Isolated Locoregional Recurrence of Breast Cancer: Final Analysis of the CALOR Trial by Wapnir, Irene L, Price, Karen N, Anderson, Stewart J, Robidoux, André, Martín, Miguel, Nortier, Johan W R, Paterson, Alexander H G, Rimawi, Mothaffar F, Láng, István, Baena-Cañada, José Manuel, Thürlimann, Beat, Mamounas, Eleftherios P, Geyer, Jr, Charles E, Gelber, Shari, Coates, Alan S, Gelber, Richard D, Rastogi, Priya, Regan, Meredith M, Wolmark, Norman, Aebi, Stefan

“…Purpose Isolated locoregional recurrence (ILRR) predicts a high risk of developing breast cancer distant metastases and death. The Chemotherapy as Adjuvant for…”
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Clinical validation of a computerized algorithm to determine mean systemic filling pressure by Meijs, Loek P.B., van Houte, Joris, Conjaerts, Bente C. M., Bindels, Alexander J. G. H., Bouwman, Arthur, Houterman, Saskia, Bakker, Jan

“…Mean systemic filling pressure (Pms) is a promising parameter in determining intravascular fluid status. Pms derived from venous return curves during…”
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Phase III Randomized Trial of Bisphosphonates as Adjuvant Therapy in Breast Cancer: S0307 by Gralow, Julie R, Barlow, William E, Paterson, Alexander H G, M'iao, Jieling L, Lew, Danika L, Stopeck, Alison T, Hayes, Daniel F, Hershman, Dawn L, Schubert, Mark M, Clemons, Mark, Van Poznak, Catherine H, Dees, Elizabeth C, Ingle, James N, Falkson, Carla I, Elias, Anthony D, Messino, Michael J, Margolis, Jeffrey H, Dakhil, Shaker R, Chew, Helen K, Dammann, Kim Z, Abrams, Jeffrey S, Livingston, Robert B, Hortobagyi, Gabriel N

“…Abstract Background Adjuvant bisphosphonates, when given in a low-estrogen environment, can decrease breast cancer recurrence and death. Treatment guidelines…”
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Azabicycloalkenes as Synthetic Intermediates:  Application to the Preparation of Diazabicycloalkane Scaffolds by Prenzel, Alexander H. G. P, Deppermann, Nina, Maison, Wolfgang

“…A general method to synthesize bicyclic dipeptide mimetics is reported. Key intermediates are azabicycloalkenes 9 and 17, which are prepared via Diels−Alder…”
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Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial by Aebi, Stefan, Dr, Gelber, Shari, MS, Anderson, Stewart J, PhD, Láng, István, MD, Robidoux, André, MD, Martín, Miguel, MD, Nortier, Johan W R, MD, Paterson, Alexander H G, MD, Rimawi, Mothaffar F, MD, Cañada, José Manuel Baena, MD, Thürlimann, Beat, MD, Murray, Elizabeth, MD, Mamounas, Eleftherios P, MD, Geyer, Charles E, MD, Price, Karen N, BS, Coates, Alan S, MD, Gelber, Richard D, PhD, Rastogi, Priya, MD, Wolmark, Norman, MD, Wapnir, Irene L, MD

“…Summary Background Patients with isolated locoregional recurrences (ILRR) of breast cancer have a high risk of distant metastasis and death from breast cancer…”
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