Search Results - "Alexander, Graeme J.M"

Senescence in chronic liver disease: Is the future in aging? by Aravinthan, Aloysious D, Alexander, Graeme J.M

“…Summary Cellular senescence is a fundamental, complex mechanism with an important protective role present from embryogenesis to late life across all species…”
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Selective insulin resistance in hepatocyte senescence by Aravinthan, Aloysious, Challis, Benjamin, Shannon, Nicholas, Hoare, Matthew, Heaney, Judith, Alexander, Graeme J.M.

“…Insulin resistance has been described in association with chronic liver disease for decades. Hepatocyte senescence has been demonstrated in chronic liver…”
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Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure by Aravinthan, Aloysious D, Alexander, Graeme J.M

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Induced pluripotent stem cells: From Nobel Prizes to clinical applications by Rashid, S. Tamir, Alexander, Graeme J.M

“…Advances in basic hepatology have been constrained for many years by the inability to culture primary hepatocytes in vitro, until just over five years ago when…”
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γ-H2AX + CD8+ T lymphocytes cannot respond to IFN-α, IL-2 or IL-6 in chronic hepatitis C virus infection by Hoare, Matthew, Shankar, Arun, Shah, Meera, Rushbrook, Simon, Gelson, William, Davies, Susan, Akbar, Arne, Alexander, Graeme J.M

“…Background & Aims Age is the dominant prognostic factor influencing the natural history of hepatitis C virus (HCV) infection and treatment response…”
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CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection by Hoare, Matthew, Gelson, William T.H, Das, Abhi, Fletcher, Jean M, Davies, Susan E, Curran, Martin D, Vowler, Sarah L, Maini, Mala K, Akbar, Arne N, Alexander, Graeme J.M

“…Background & Aims Increasing age is associated with impaired immune function and in chronic HCV infection specifically, with progressive fibrosis, liver…”
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Comparison of endothelin receptors in normal versus cirrhotic human liver and in the liver from endothelial cell-specific ETB knockout mice by Ling, Lowell, Kuc, Rhoda E., Maguire, Janet J., Davie, Neil J., Webb, David J., Gibbs, Paul, Alexander, Graeme J.M., Davenport, Anthony P.

“…Endothelin (ET) antagonists show promise in animal models of cirrhosis and portal hypertension. The aim was to pharmacologically characterise the expression of…”
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European collaborative study on factors influencing outcome after liver transplantation for hepatitis C by Féray, Cyrille, Caccamo, Lucio, Alexander, Graeme J.M., Ducot, Béatrice, Gugenheim, Jean, Casanovas, Teresa, Loinaz, Carmelo, Gigou, Michele, Burra, Patrizia, Barkholt, Lisbeth, Esteban, Raffael, Bizollon, Thierry, Lerut, Jan, Minello–Franza, Anne, Bernard, Pierre–Henri, Nachbaur, Karl, Botta–Fridlund, Danielle, Bismuth, Henri, Schalm, Solko W., Samuel, Didier

“…Background & Aims: Liver transplantation for hepatitis C virus (HCV)-related liver disease is characterized by frequent graft infection by HCV. The prognosis…”
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A single centre experience of liver disease in adults with cystic fibrosis 1995–2006 by Nash, K.L, Allison, M.E, McKeon, D, Lomas, D.J, Haworth, C.S, Bilton, D, Alexander, Graeme J.M

“…Abstract Background Liver disease is an important cause of death in adults with cystic fibrosis (CF). Ursodeoxycholic acid (UDCA) may slow progression…”
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Event-biased referral can distort estimation of hepatitis C virus progression rate to cirrhosis, and of prognostic influences by Fu, Bo, Tom, Brian D.M, Delahooke, Toby, Alexander, Graeme J.M, Bird, Sheila M

“…Abstract Objective To investigate how cirrhosis-biased referral to liver clinics can explain the wide variation in progression rates for differently recruited…”
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Early indicators of prognosis in fulminant hepatic failure by O'Grady, J G, Alexander, G J, Hayllar, K M, Williams, R

“…The successful use of orthotopic liver transplantation in fulminant hepatic failure has created a need for early prognostic indicators to select the patients…”
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Improvement by Acetylcysteine of Hemodynamics and Oxygen Transport in Fulminant Hepatic Failure by Harrison, Phillip M, Wendon, Julia A, Gimson, Alexander E.S, Alexander, Graeme J.M, Williams, Roger

“…IN normal subjects tissue oxygen consumption is maintained at around 110 ml per minute per square meter of body-surface area, and changes in oxygen delivery…”
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The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines by Hirschfield, Gideon M, Dyson, Jessica K, Alexander, Graeme J M, Chapman, Michael H, Collier, Jane, Hübscher, Stefan, Patanwala, Imran, Pereira, Stephen P, Thain, Collette, Thorburn, Douglas, Tiniakos, Dina, Walmsley, Martine, Webster, George, Jones, David E J

“…Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary…”
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Cytomegalovirus infection of bile duct epithelial cells, hepatic artery and portal venous endothelium in relation to chronic rejection of liver grafts by Evans, Paul C, Coleman, Nick, Wreghitt, Tim G, Wight, Derek G.D, Alexander, Graeme J.M

“…Background/Aim: Chronic rejection is an important cause of graft loss following liver transplantation. A number of risk factors for chronic rejection have been…”
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High-level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis by Lau, J Y, Bain, V G, Davies, S E, O'Grady, J G, Alberti, A, Alexander, G J, Williams, R

“…The expression of hepatitis B viral antigens was quantified in liver tissue from four transplant recipients with fibrosing cholestatic hepatitis (FCH) and…”
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The safety and value of extradural intracranial pressure monitors in fulminant hepatic failure by Keays, R T, Alexander, G J, Williams, R

“…Thirty-six of 68 consecutive patients with fulminant hepatic failure (FHF) progressing to grade 4 encephalopathy who had extradural ICP monitors inserted were…”
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Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease by Aravinthan, Aloysious, Pietrosi, Giada, Hoare, Matthew, Jupp, James, Marshall, Aileen, Verrill, Clare, Davies, Susan, Bateman, Adrian, Sheron, Nick, Allison, Michael, Alexander, Graeme J M

“…Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol…”
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The senescent hepatocyte gene signature in chronic liver disease by Aravinthan, Aloysious, Shannon, Nicholas, Heaney, Judith, Hoare, Matthew, Marshall, Aileen, Alexander, Graeme J.M.

“…Hepatocyte senescence is associated closely with fibrosis stage and an adverse outcome in chronic liver disease, but it is uncertain whether there is a causal…”
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Hepatitis C Virus Genomic Variability in Untreated and Immunosuppressed Patients by LAWAL, ZARAH, PETRIK, JURAJ, WONG, VOI-SHIM, ALEXANDER, GRAEME J.M, ALLAIN, JEAN-PIERRE

“…To investigate whether immune pressure enhances the genetic diversity of the hepatitis C virus (HCV) hypervariable region 1, nucleotide sequences were compared…”
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Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver by Verma, Suman, Tachtatzis, Phaedra, Penrhyn-Lowe, Sue, Scarpini, Cinzia, Jurk, Diana, Von Zglinicki, Thomas, Coleman, Nick, Alexander, Graeme J. M.

“…Telomeres, a validated biomarker of aging, comprise multiple nucleotide repeats capping chromosomes that shorten with each cell cycle until a critical length…”
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