Search Results - "Alexander, Graeme J."

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation by Sampaziotis, Fotios, Cardoso de Brito, Miguel, Madrigal, Pedro, Bertero, Alessandro, Saeb-Parsy, Kourosh, Soares, Filipa A C, Schrumpf, Elisabeth, Melum, Espen, Karlsen, Tom H, Bradley, J Andrew, Gelson, William T H, Davies, Susan, Baker, Alastair, Kaser, Arthur, Alexander, Graeme J, Hannan, Nicholas R F, Vallier, Ludovic

“…A protocol for generating biliary epithelial cells from human pluripotent stem cells facilitates disease modeling and drug screening. The study of biliary…”
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Sex and Age Are Determinants of the Clinical Phenotype of Primary Biliary Cirrhosis and Response to Ursodeoxycholic Acid by Carbone, Marco, Mells, George F, Pells, Greta, Dawwas, Muhammad F, Newton, Julia L, Heneghan, Michael A, Neuberger, James M, Day, Darren B, Ducker, Samantha J, Sandford, Richard N, Alexander, Graeme J, Jones, David E.J

“…Background, & Aims Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has…”
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The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines by Hirschfield, Gideon M, Dyson, Jessica K, Alexander, Graeme J M, Chapman, Michael H, Collier, Jane, Hübscher, Stefan, Patanwala, Imran, Pereira, Stephen P, Thain, Collette, Thorburn, Douglas, Tiniakos, Dina, Walmsley, Martine, Webster, George, Jones, David E J

“…Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary…”
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Hepatocyte expression of the senescence marker p21 is linked to fibrosis and an adverse liver-related outcome in alcohol-related liver disease by Aravinthan, Aloysious, Pietrosi, Giada, Hoare, Matthew, Jupp, James, Marshall, Aileen, Verrill, Clare, Davies, Susan, Bateman, Adrian, Sheron, Nick, Allison, Michael, Alexander, Graeme J M

“…Alcohol-related liver disease (ALD) remains a leading cause of liver-related morbidity and mortality. Age, fibrosis stage, MELD score and continued alcohol…”
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Impact of primary biliary cirrhosis on perceived quality of life: The UK‐PBC national study by Mells, George F., Pells, Greta, Newton, Julia L., Bathgate, Andrew J., Burroughs, Andrew K., Heneghan, Michael A., Neuberger, James M., Day, Darren B., Ducker, Samantha J., Sandford, Richard N., Alexander, Graeme J., Jones, David E.J.

“…Primary biliary cirrhosis (PBC) has a complex clinical phenotype, with debate about the extent and specificity of frequently described systemic symptoms such…”
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Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver by Verma, Suman, Tachtatzis, Phaedra, Penrhyn-Lowe, Sue, Scarpini, Cinzia, Jurk, Diana, Von Zglinicki, Thomas, Coleman, Nick, Alexander, Graeme J. M.

“…Telomeres, a validated biomarker of aging, comprise multiple nucleotide repeats capping chromosomes that shorten with each cell cycle until a critical length…”
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Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis by Tachtatzis, Phaedra M, Marshall, Aileen, Arvinthan, Aloysious, Aravinthan, Aloysius, Verma, Suman, Penrhyn-Lowe, Sue, Mela, Marianna, Scarpini, Cinzia, Davies, Susan E, Coleman, Nicholas, Alexander, Graeme J M

“…Chronic Hepatitis B virus (HBV) infection can lead to the development of chronic hepatitis, cirrhosis and hepatocellular carcinoma. We hypothesized that HBV…”
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Regulatory T Cells Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Persistent Hepatitis C Virus Infection by RUSHBROOK, Simon M, WARD, Scott M, UNITT, Esther, VOWLER, Sarah L, LUCAS, Michaela, KLENERMAN, Paul, ALEXANDER, Graeme J. M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation by Unitt, Esther, Marshall, Aileen, Gelson, William, Rushbrook, Simon M., Davies, Susan, Vowler, Sarah L., Morris, Lesley S., Coleman, Nicholas, Alexander, Graeme J.M.

“…Liver transplantation is an effective treatment for highly selected patients with hepatocellular carcinoma (HCC), but tumour recurrence remains an important…”
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Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression by Wijayasiri, Pramudi, Astbury, Stuart, Kaye, Philip, Oakley, Fiona, Alexander, Graeme J, Kendall, Timothy J, Aravinthan, Aloysious D

“…Hepatocyte senescence is associated with liver fibrosis. However, the possibility of a direct, causal relation between hepatocyte senescence and hepatic…”
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Consistent beneficial effects of killer cell immunoglobulin‐like receptor 2DL3 and group 1 human leukocyte antigen‐C following exposure to hepatitis C virus by Knapp, Susanne, Warshow, Usama, Hegazy, Doha, Brackenbury, Louise, Guha, I. Neil, Fowell, Andrew, Little, Ann‐Margaret, Alexander, Graeme J., Rosenberg, William M.C., Cramp, Matthew E., Khakoo, Salim I.

“…Natural killer cells are a key component in the immune control of viral infections. Their functions are controlled by inhibitory receptors for major…”
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HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection by Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, Cheng, Jie, Goedert, James J., Vlahov, David, Hilgartner, Margaret, Cox, Steven, Little, Ann-Margeret, Alexander, Graeme J., Cramp, Matthew E., O'Brien, Stephen J., William M. C. Rosenberg, Thomas, David L., Carrington, Mary

“…Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex…”
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Compromised lymphocytes infiltrate hepatocellular carcinoma : The role of T-regulatory cells by UNITT, Esther, RUSHBROOK, Simon M, MARSHALL, Aileen, DAVIES, Susan, GIBBS, Paul, MORRIS, Lesley S, COLEMAN, Nicholas, ALEXANDER, Graeme J. M

“…Hepatocellular carcinoma (HCC) has a poor prognosis with limited therapeutic options. We propose that local immune responses in patients with HCC are held in…”
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A viral discovery methodology for clinical biopsy samples utilising massively parallel next generation sequencing by Daly, Gordon M, Bexfield, Nick, Heaney, Judith, Stubbs, Sam, Mayer, Antonia P, Palser, Anne, Kellam, Paul, Drou, Nizar, Caccamo, Mario, Tiley, Laurence, Alexander, Graeme J M, Bernal, William, Heeney, Jonathan L

“…Here we describe a virus discovery protocol for a range of different virus genera, that can be applied to biopsy-sized tissue samples. Our viral enrichment…”
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Reduced circulating BMP10 and BMP9 and elevated endoglin are associated with disease severity, decompensation and pulmonary vascular syndromes in patients with cirrhosis by Owen, Nicola E., Alexander, Graeme J., Sen, Sambit, Bunclark, Katherine, Polwarth, Gary, Pepke-Zaba, Joanna, Davenport, Anthony P., Morrell, Nicholas, W., Upton, Paul. D.

“…BMP9, originating from the liver, and BMP10 are circulating BMPs that preserve vascular endothelial integrity. We assessed BMP9, BMP10 and soluble endoglin…”
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Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis by Darlay, Rebecca, Ayers, Kristin L, Mells, George F, Hall, Lynsey S, Liu, Jimmy Z, Almarri, Mohamed A, Alexander, Graeme J, Jones, David E, Sandford, Richard N, Anderson, Carl A, Cordell, Heather J

“…Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by progressive destruction of intrahepatic bile ducts. The strongest…”
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The senescent hepatocyte gene signature in chronic liver disease by Aravinthan, Aloysious, Shannon, Nicholas, Heaney, Judith, Hoare, Matthew, Marshall, Aileen, Alexander, Graeme J.M.

“…Hepatocyte senescence is associated closely with fibrosis stage and an adverse outcome in chronic liver disease, but it is uncertain whether there is a causal…”
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Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C by Chen, Annie Y, Hoare, Matthew, Shankar, Arun N, Allison, Michael, Alexander, Graeme J M, Michalak, Tomasz I

“…Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited…”
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Age-related Macular Degeneration and Modification of Systemic Complement Factor H Production Through Liver Transplantation by Khandhadia, Samir, MBBS, MRCOphth, Hakobyan, Svetlana, PhD, Heng, Ling Z., MBBS, Gibson, Jane, PhD, Adams, David H., MD, FMedSci, Alexander, Graeme J., MD, FRCP, Gibson, Jonathan M., MD, FRCOphth, Martin, Keith R., MRCP, FRCOphth, Menon, Geeta, FRCS (Ophth), FRCOphth, Nash, Kathryn, FRCP, PhD, Sivaprasad, Sobha, FRCS, Ennis, Sarah, PhD, Cree, Angela J., BSc, Morgan, B. Paul, FRCPath, FMedSci, Lotery, Andrew J., MD, FRCOphth

“…Purpose To investigate whether modification of liver complement factor H (CFH) production, by alteration of liver CFH Y402H genotype through liver…”
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Magnetic resonance elastography in the detection of hepatorenal syndrome in patients with cirrhosis and ascites by Low, Gavin, Owen, Nicola E., Joubert, Ilse, Patterson, Andrew J., Graves, Martin J., Alexander, Graeme J. M., Lomas, David J.

“…Objective Hepatorenal syndrome (HRS) is the most lethal cause of renal impairment in cirrhosis. Magnetic resonance elastography (MRE) is a diagnostic test that…”
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