Search Results - "Alexander, G E"

Designing Hydrogels for 3D Cell Culture Using Dynamic Covalent Crosslinking by Rizwan, Muhammad, Baker, Alexander E. G., Shoichet, Molly S.

“…Designing simple biomaterials to replicate the biochemical and mechanical properties of tissues is an ongoing challenge in tissue engineering. For several…”
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Independently Tuning the Biochemical and Mechanical Properties of 3D Hyaluronan-Based Hydrogels with Oxime and Diels–Alder Chemistry to Culture Breast Cancer Spheroids by Baker, Alexander E. G, Tam, Roger Y, Shoichet, Molly S

“…For native breast cancer cell growth to be mimicked in vitro as spheroids, a well-defined matrix that mimics the tumor microenvironment is required. Finding a…”
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Diels–Alder Click-Cross-Linked Hydrogels with Increased Reactivity Enable 3D Cell Encapsulation by Smith, Laura J, Taimoory, S. Maryamdokht, Tam, Roger Y, Baker, Alexander E. G, Binth Mohammad, Niema, Trant, John F, Shoichet, Molly S

“…Engineered hydrogels have been extensively used to direct cell function in 3D cell culture models, which are more representative of the native cellular…”
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Optical Control of Cannabinoid Receptor 2‑Mediated Ca2+ Release Enabled by Synthesis of Photoswitchable Probes by Sarott, Roman C, Viray, Alexander E. G, Pfaff, Patrick, Sadybekov, Anastasiia, Rajic, Gabriela, Katritch, Vsevolod, Carreira, Erick M, Frank, James A

“…Cannabinoid receptor 2 (CB2) is a promising target for the treatment of neuroinflammation and other diseases. However, a lack of understanding of its complex…”
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Synthesis of an Enzyme-Mediated Reversible Cross-linked Hydrogel for Cell Culture by Smith, Kelti A, Dang, Mickael, Baker, Alexander E. G, Fuehrmann, Tobias, Fokina, Ana, Shoichet, Molly S

“…Detachment of fragile cell types cultured on two-dimensional (2D) surfaces has been shown to be detrimental to their viability. For example, detachment of…”
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Using intervention mapping to develop an intervention for multiparty communication with people with congenital deafblindness by Worm, Mijkje, Damen, Saskia, Janssen, Marleen J, Minnaert, Alexander E M G

“…Due to their dual sensory impairment, people with congenital deafblindness (CDB) are rarely naturally involved in other people's conversations. Their…”
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Genetically-targeted photorelease of endocannabinoids enables optical control of GPR55 in pancreatic β-cells by Tobias, Janelle M, Rajic, Gabriela, Viray, Alexander E. G, Icka-Araki, David, Frank, James A

“…Fatty acid amides (FAAs) are a family of second-messenger lipids that target cannabinoid receptors, and are known mediators of glucose-stimulated insulin…”
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Bacterial recombination promotes the evolution of multi-drug-resistance in functionally diverse populations by Perron, Gabriel G, Lee, Alexander E. G, Wang, Yun, Huang, Wei E, Barraclough, Timothy G

“…Bacterial recombination is believed to be a major factor explaining the prevalence of multi-drug-resistance (MDR) among pathogenic bacteria. Despite extensive…”
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Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High‐Content Drug Screening by Tam, Roger Y., Yockell‐Lelièvre, Julien, Smith, Laura J., Julian, Lisa M., Baker, Alexander E. G., Choey, Chandarong, Hasim, Mohamed S., Dimitroulakos, Jim, Stanford, William L., Shoichet, Molly S.

“…Cell behavior is highly dependent upon microenvironment. Thus, to identify drugs targeting metastatic cancer, screens need to be performed in tissue mimetic…”
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Role of the posterior parietal cortex in updating reaching movements to a visual target by Grafton, S. T, Desmurget, M, Epstein, C. M, Turner, R. S, Prablanc, C, Alexander, G. E

“…The exact role of posterior parietal cortex (PPC) in visually directed reaching is unknown. We propose that, by building an internal representation of…”
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Development and process evaluation of a motor activity program for people with profound intellectual and multiple disabilities by van Alphen, Helena J M, Waninge, Aly, Minnaert, Alexander E M G, van der Putten, Annette A J

“…The support of people with profound intellectual and multiple disabilities (PIMD) rarely focused on motor activity, which might have negative consequences for…”
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Hyaluronic Acid-Based Hydrogels Enable Rod Photoreceptor Survival and Maturation In Vitro through Activation of the mTOR Pathway by Mitrousis, Nikolaos, Tam, Roger Y., Baker, Alexander E. G., van der Kooy, Derek, Shoichet, Molly S.

“…The culture of isolated photoreceptors in vitro has remained elusive in ­neuroscience. By using defined hyaluronic acid (HA) hydrogels, photo­receptor survival…”
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Temporally Controlled Photouncaged Epidermal Growth Factor Influences Cell Fate in Hydrogels by Lu, Yung Hsiang, Baker, Alexander E. G, Fokina, Ana, Kufleitner, Markus, Kivijäri, Tove, Shoichet, Molly S

“…Hydrogels are powerful materials that more accurately mimic the cellular microenvironment over static two-dimensional culture. Photochemical strategies enable…”
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Construct validity of the Actiwatch‐2 for assessing movement in people with profound intellectual and multiple disabilities by Alphen, Helena J. M., Waninge, Aly, Minnaert, Alexander E. M. G., Post, Wendy J., Putten, Annette A. J.

“…Background Valid measures to assess either small or assisted performed movements of people with profound intellectual and multiple disabilities (PIMD) are…”
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Flipping the GPCR Switch: Structure-Based Development of Selective Cannabinoid Receptor 2 Inverse Agonists by Kosar, Miroslav, Sarott, Roman C., Sykes, David A., Viray, Alexander E. G., Vitale, Rosa Maria, Tomašević, Nataša, Li, Xiaoting, Ganzoni, Rudolf L. Z., Kicin, Bilal, Reichert, Lisa, Patej, Kacper J., Gómez-Bouzó, Uxía, Guba, Wolfgang, McCormick, Peter J., Hua, Tian, Gruber, Christian W., Veprintsev, Dmitry B., Frank, James A., Grether, Uwe, Carreira, Erick M.

“…We report a blueprint for the rational design of G protein coupled receptor (GPCR) ligands with a tailored functional response. The present study discloses the…”
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An Improved Method for the Synthesis of F-BODIPYs from Dipyrrins and Bis(dipyrrin)s by Lundrigan, Travis, Baker, Alexander E. G, Longobardi, Lauren E, Wood, Tabitha E, Smithen, Deborah A, Crawford, Sarah M, Cameron, T. Stanley, Thompson, Alison

“…An improved methodology for the synthesis of F-BODIPYs from dipyrrins and bis(dipyrrin)s is reported. This strategy employs lithium salts of dipyrrins as…”
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Phenotypic assortment in wild primate networks: implications for the dissemination of information by Carter, Alecia J., Lee, Alexander E. G., Marshall, Harry H., Ticó, Miquel Torrents, Cowlishaw, Guy

“…Individuals' access to social information can depend on their social network. Homophily—a preference to associate with similar phenotypes—may cause assortment…”
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Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy by Fisher, Stephanie A, Baker, Alexander E.G, Shoichet, Molly S

“…Hydrogels are used in a wide variety of biomedical applications including tissue engineering, biomolecule delivery, cell delivery, and cell culture. These…”
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Activation of brain regions vulnerable to Alzheimer's disease: The effect of mild cognitive impairment by Johnson, S.C., Schmitz, T.W., Moritz, C.H., Meyerand, M.E., Rowley, H.A., Alexander, A.L., Hansen, K.W., Gleason, C.E., Carlsson, C.M., Ries, M.L., Asthana, S., Chen, K., Reiman, E.M., Alexander, G.E.

“…This study examined the functionality of the medial temporal lobe (MTL) and posterior cingulate (PC) in mild cognitive impairment amnestic type (MCI), a…”
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Switching spatial scale reveals dominance-dependent social foraging tactics in a wild primate by Lee, Alexander E G, Cowlishaw, Guy

“…When foraging in a social group, individuals are faced with the choice of sampling their environment directly or exploiting the discoveries of others. The…”
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