Search Results - "Alexa, P"

Guselkumab in biologic-naive patients with active psoriatic arthritis (DISCOVER-2): a double-blind, randomised, placebo-controlled phase 3 trial by Mease, Philip J, Rahman, Proton, Gottlieb, Alice B, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Zhuang, Yanli, van der Heijde, Désirée, McInnes, Iain B

“…The interleukin-23 (IL-23)/T-helper 17 cell pathway is implicated in psoriatic arthritis pathogenesis. Guselkumab, an IL-23 inhibitor that specifically binds…”
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Guselkumab in patients with active psoriatic arthritis who were biologic-naive or had previously received TNFα inhibitor treatment (DISCOVER-1): a double-blind, randomised, placebo-controlled phase 3 trial by Deodhar, Atul, Helliwell, Philip S, Boehncke, Wolf-Henning, Kollmeier, Alexa P, Hsia, Elizabeth C, Subramanian, Ramanand A, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Zhuang, Yanli, Ritchlin, Christopher T

“…Many patients with psoriatic arthritis have an inadequate response to tumor necrosis factor (TNF) inhibitors. Guselkumab, a specific inhibitor of…”
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The biophysics of cell motility through mechanochemically challenging environments by Caruso, Alexa P., Logue, Jeremy S.

“…Challenging mechanochemical environments (i.e., with varied mechanical and adhesive properties) are now known to induce a wide range of adaptive phenomena in…”
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Age- and sex-associated differences in hematology and biochemistry parameters of Dunkin Hartley guinea pigs (Cavia porcellus) by Spittler, Alexa P, Afzali, Maryam F, Bork, Sydney B, Burton, Lindsey H, Radakovich, Lauren B, Seebart, Cassie A, Moore, A. Russell, Santangelo, Kelly S

“…The Dunkin Hartley is the most common guinea pig strain used in biomedical research, particularly for studies of asthma, allergy, infectious disease,…”
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Long‐Term Efficacy and Safety of Guselkumab, a Monoclonal Antibody Specific to the p19 Subunit of Interleukin‐23, Through Two Years: Results From a Phase III, Randomized, Double‐Blind, Placebo‐Controlled Study Conducted in Biologic‐Naive Patients With Active Psoriatic Arthritis by McInnes, Iain B., Rahman, Proton, Gottlieb, Alice B., Hsia, Elizabeth C., Kollmeier, Alexa P., Xu, Xie L., Jiang, Yusang, Sheng, Shihong, Shawi, May, Chakravarty, Soumya D., Heijde, Désirée, Mease, Philip J.

“…Objective To assess long‐term efficacy and safety of guselkumab, an interleukin‐23 p19 subunit (IL‐23p19) inhibitor, in patients with active psoriatic…”
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Preference of Bacterial Rhamnosyltransferases for 6‑Deoxysugars Reveals a Strategy To Deplete O‑Antigens by Harnagel, Alexa P., Sheshova, Mia, Zheng, Meng, Zheng, Maggie, Skorupinska-Tudek, Karolina, Swiezewska, Ewa, Lupoli, Tania J.

“…Bacteria synthesize hundreds of bacteria-specific or “rare” sugars that are absent in mammalian cells and enriched in 6-deoxy monosaccharides such as…”
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Guselkumab demonstrated an independent treatment effect in reducing fatigue after adjustment for clinical response-results from two phase 3 clinical trials of 1120 patients with active psoriatic arthritis by Rahman, Proton, Mease, Philip J, Helliwell, Philip S, Deodhar, Atul, Gossec, Laure, Kavanaugh, Arthur, Kollmeier, Alexa P, Hsia, Elizabeth C, Zhou, Bei, Lin, Xiwu, Shawi, May, Karyekar, Chetan S, Han, Chenglong

“…The interleukin-23p19-subunit inhibitor guselkumab effectively treats signs and symptoms of psoriatic arthritis (PsA). We evaluated the effect of guselkumab on…”
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Chemical Biology Tools for Modulating and Visualizing Gram-Negative Bacterial Surface Polysaccharides by Zheng, Meng, Zheng, Maggie, Epstein, Samuel, Harnagel, Alexa P, Kim, Hanee, Lupoli, Tania J

“…Bacterial cells present a wide diversity of saccharides that decorate the cell surface and help mediate interactions with the environment. Many Gram-negative…”
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Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice by Sasson, Isaac E., Vitins, Alexa P., Mainigi, Monica A., Moley, Kelle H., Simmons, Rebecca A.

“…Aims/hypothesis Maternal obesity is associated with an increased risk of obesity and impaired glucose homeostasis in offspring. However, it is not known…”
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Implementation of a Trauma Bay Checklist Improves Antibiotic Prophylaxis Compliance in Open Extremity Fractures by Luke, Robert D, Balio, Casey P, Foley, Claire K, Soult, Alexa P

“…Best practice guidelines from the ACS recommend that patients with open fractures receive antibiotics within 1-hour of presentation. Checklists are effective…”
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Emerin regulation of nuclear stiffness is required for fast amoeboid migration in confined environments by Lavenus, Sandrine B, Vosatka, Karl W, Caruso, Alexa P, Ullo, Maria F, Khan, Ayesha, Logue, Jeremy S

“…When metastasizing, tumor cells must traverse environments with diverse physicochemical properties. Recently, the cell nucleus has emerged as a major regulator…”
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Long-Term Safety of Guselkumab in Patients with Psoriatic Disease: An Integrated Analysis of Eleven Phase II/III Clinical Studies in Psoriasis and Psoriatic Arthritis by Strober, Bruce, Coates, Laura C., Lebwohl, Mark G., Deodhar, Atul, Leibowitz, Evan, Rowland, Katelyn, Kollmeier, Alexa P., Miller, Megan, Wang, Yanli, Li, Shu, Chakravarty, Soumya D., Chan, Daphne, Shawi, May, Yang, Ya-Wen, Thaҫi, Diamant, Rahman, Proton

“…Introduction The benefit/risk profiles of biologics can be affected by comorbidities, certain demographic characteristics, and concomitant medications;…”
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Adolescent Long-Acting Reversible Contraceptive Use, Same-Day Insertions, and Pregnancies Following a Quality Initiative by Bruce, Kelly H., Merchant, Maqdooda A., Kaskowitz, Alexa P., Mickelsen, Riley S., Lau, Josephine S.

“…To compare long-acting reversible contraceptive (LARC) use, pregnancy rate, and same-day LARC insertion among adolescents before and after a Kaiser Permanente…”
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Safety of Guselkumab With and Without Prior Tumor Necrosis Factor Inhibitor Treatment: Pooled Results Across 4 Studies in Patients With Psoriatic Arthritis by Rahman, Proton, Boehncke, Wolf-Henning, Mease, Philip J, Gottlieb, Alice B, McInnes, Iain B, Shawi, May, Wang, Yanli, Sheng, Shihong, Kollmeier, Alexa P, Theander, Elke, Yu, Jenny, Leibowitz, Evan, Marrache, A Marilise, Coates, Laura C

“…Assess pooled safety results through the end of the phase II/III studies of guselkumab (GUS; ≤ 2 years) in tumor necrosis factor inhibitor (TNFi)-naïve and…”
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Novel insights into chorioretinal and juxtapapillary colobomas by optical coherence tomography by Gray, Alexa P., Sato, Yu, Miyadera, Keiko, Aguirre, Gustavo D.

“…Purpose The purpose was to describe the in vivo microanatomy of typical and atypical chorioretinal and juxtapapillary colobomas in the dog. Methods Three…”
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The first experimental evidence for the (M1 + E2) mixed character of the 9.2 keV transition in 227Th by Kovalík, A., Inoyatov, A.Kh, Perevoshchikov, L.L., Ryšavý, M., Filosofov, D.V., Alexa, P., Kvasil, J.

“…The 9.2 keV nuclear transition in 227Th was studied in the β−-decay of 227Ac by means of the internal conversion electron spectroscopy to clarify the…”
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Resolution of enthesitis by guselkumab and relationships to disease burden: 1-year results of two phase 3 psoriatic arthritis studies by McGonagle, Dennis, McInnes, Iain B, Deodhar, Atul, Schett, Georg, Shawi, May, Kafka, Shelly, Karyekar, Chetan S, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Ritchlin, Christopher T, Rahman, Proton, Mease, Philip J

“…To further characterize the effect of guselkumab, a selective IL-23p19-subunit inhibitor approved for PsA, on enthesitis and assess relationships between…”
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Macroscopic and Skyrme-Hartree-Fock test of E(5) symmetry in xenon isotopes by Abolghasem, M, Cuxac, B, Thiamova, G, Alexa, P

“…Algebraic collective model calculations for even-even xenon isotopes 128,130Xe have been performed to describe collective properties of these two isotopes,…”
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7Be atmospheric activity concentration and meteorological data: Statistical analysis and two-layer atmospheric model by Uhlář, R., Haroková, P., Alexa, P., Kačmařík, M.

“…Atmospheric activity concentration of 7Be in the air was monitored during the period of one year from September 2015 to September 2016 at Ostrava, Czech…”
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Pooled Safety Results Through 1 Year of 2 Phase III Trials of Guselkumab in Patients With Psoriatic Arthritis by Rahman, Proton, Ritchlin, Christopher T, Helliwell, Philip S, Boehncke, Wolf-Henning, Mease, Philip J, Gottlieb, Alice B, Kafka, Shelly, Kollmeier, Alexa P, Hsia, Elizabeth C, Xu, Xie L, Shawi, May, Sheng, Shihong, Agarwal, Prasheen, Zhou, Bei, Ramachandran, Paraneedharan, Zhuang, Yanli, McInnes, Iain B

“…Evaluate the safety of guselkumab (monoclonal antibody targeting interleukin [IL]-23p19) in patients with psoriatic arthritis (PsA) through 1 year (1Y) of the…”
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