Search Results - "Alex J. Raeber"

Prion disease blood test using immunoprecipitation and improved quaking-induced conversion by Orrú, Christina D, Wilham, Jason M, Raymond, Lynne D, Kuhn, Franziska, Schroeder, Björn, Raeber, Alex J, Caughey, Byron

“…A key challenge in managing transmissible spongiform encephalopathies (TSEs) or prion diseases in medicine, agriculture, and wildlife biology is the…”
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Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice by Nazor, Karah E, Kuhn, Franziska, Seward, Tanya, Green, Mike, Zwald, Daniel, Pürro, Mario, Schmid, Jaqueline, Biffiger, Karin, Power, Aisling M, Oesch, Bruno, Raeber, Alex J, Telling, Glenn C

“…The absence of infectivity‐associated, protease‐resistant prion protein (PrPSc) in the brains of spontaneously sick transgenic (Tg) mice overexpressing PrP…”
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Biological Effects and Use of PrPSc- and PrP-Specific Antibodies Generated by Immunization with Purified Full-Length Native Mouse Prions by PETSCH, Benjamin, MÜLLER-SCHIFFMANN, Andreas, LEHLE, Anna, ZIRDUM, Elizabeta, PRIKULIS, Ingrid, KUHN, Franziska, RAEBER, Alex J, IRONSIDE, James W, KORTH, Carsten, STITZ, Lothar

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Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice by Flechsig, E, Shmerling, D, Hegyi, I, Raeber, A J, Fischer, M, Cozzio, A, von Mering, C, Aguzzi, A, Weissmann, C

“…Mice devoid of PrP are resistant to scrapie and fail to replicate the agent. Introduction of transgenes expressing PrP into such mice restores susceptibility…”
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MAP1272c Encodes an NlpC/P60 Protein, an Antigen Detected in Cattle with Johne's Disease by Bannantine, John P, Lingle, Cari K, Stabel, Judith R, Ramyar, Kasra X, Garcia, Brandon L, Raeber, Alex J, Schacher, Pascal, Kapur, Vivek, Geisbrecht, Brian V

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PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain by Aguzzi, Adriano, Blättler, Thomas, Brandner, Sebastian, Raeber, Alex J, Klein, Michael A, Voigtländer, Till, Weissmann, Charles

“…Much available evidence points to a pathological isoform of the prion protein PrP being the infectious agent that causes transmissible spongiform…”
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Current ante-mortem techniques for diagnosis of bovine tuberculosis by Bezos, Javier, Casal, Carmen, Romero, Beatriz, Schroeder, Bjoern, Hardegger, Roland, Raeber, Alex J., López, Lissette, Rueda, Paloma, Domínguez, Lucas

“…Bovine tuberculosis (TB), mainly caused by Mycobacterium bovis, is a zoonotic disease with implications for Public Health and having an economic impact due to…”
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Ectopic Expression of Prion Protein (PrP) in T Lymphocytes Or Hepatocytes of PrP Knockout Mice Is Insufficient to Sustain Prion Replication by Raeber, Alex J., Sailer, Andreas, Hegyi, Ivan, Klein, Michael A., Rülicke, Thomas, Fischer, Marek, Brandner, Sebastian, Aguzzi, Adriano, Weissmann, Charles

“…The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under…”
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Soluble dimeric prion protein binds PrP(Sc) in vivo and antagonizes prion disease by Meier, Philipp, Genoud, Nicolas, Prinz, Marco, Maissen, Manuela, Rülicke, Thomas, Zurbriggen, Andreas, Raeber, Alex J, Aguzzi, Adriano

“…Conversion of cellular prion protein (PrP(C)) into a pathological conformer (PrP(Sc)) is thought to be promoted by PrP(Sc) in a poorly understood process…”
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Soluble Dimeric Prion Protein Binds PrPSc In Vivo and Antagonizes Prion Disease by Meier, Philipp, Genoud, Nicolas, Prinz, Marco, Maissen, Manuela, Rülicke, Thomas, Zurbriggen, Andreas, Raeber, Alex J, Aguzzi, Adriano

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crucial role for B cells in neuroinvasive scrapie by Klein, M.A, Frigg, R, Flechsig, E, Raeber, A.J, Kalinke, U, Bluethmann, H, Bootz, F, Suter, M, Zinkernagel, R.M, Agussi, A

“…Although prion proteins are most efficiently propagated through intracerebral inoculation, peripheral administration has caused the diseases kuru, iatrogenic…”
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PrP expression in B lymphocytes is not required for prion neuroinvasion by Aguzzi, Adriano, Klein, Michael A, Frigg, Rico, Raeber, Alex J, Flechsig, Eckhard, Hegyi, Ivan, Zinkernagel, Rolf M, Weissmann, Charles

“…Prion diseases are typically initiated by infection of peripheral sites, as in the case of bovine spongiform encephalopathy, new variant Creutzfeldt-Jakob…”
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Diagnosis of prion diseases by Kübler, Eric, Oesch, Bruno, Raeber, Alex J

“…Prion diseases are usually diagnosed clinically and confirmed by post-mortem histopathological examination of brain tissue. The only reliable molecular marker…”
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Evaluation of a new commercial enzyme-linked immunosorbent assay for the detection of porcine antibodies against Trichinella spp by Frey, Caroline F, Buholzer, Patrik, Beck, Relja, Marinculic, Albert, Raeber, Alex J, Gottstein, Bruno, Schuppers, Manon E

“…Correspondence: 1 Corresponding Author: Caroline Frey, Vetsuisse Faculty, University of Bern, Institute of Parasitology, PO Box 8466, 3001 Bern, Switzerland…”
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Similar Turnover and Shedding of the Cellular Prion Protein in Primary Lymphoid and Neuronal Cells by Parizek, P, Roeckl, C, Weber, J, Flechsig, E, Aguzzi, A, Raeber, A J

“…The cellular prion protein (PrP C ) is essential for pathogenesis and transmission of prion diseases. Although prion replication in the brain is accompanied by…”
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Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie by Raeber, Alex J., Race, Richard E., Brandner, Sebastian, Priola, Suzette A., Sailer, Andreas, Bessen, Richard A., Mucke, Lennart, Manson, Jean, Aguzzi, Adriano, Oldstone, Michael B.A., Weissmann, Charles, Chesebro, Bruce

“…Transmissible spongiform encephalopathies are characterized by spongiosis, astrocytosis and accumulation of PrPSc, an isoform of the normal host protein PrPC…”
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PrP-dependent association of prions with splenic but not circulating lymphocytes of scrapie-infected mice by Raeber, Alex J., Klein, Michael A., Frigg, Rico, Flechsig, Eckhard, Aguzzi, Adriano, Weissmann, Charles

“…An intact immune system, and particularly the presence of mature B lymphocytes, is crucial for mouse scrapie pathogenesis in the brain after peripheral…”
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B Lymphocyte-Restricted Expression of Prion Protein Does Not Enable Prion Replication in Prion Protein Knockout Mice by Montrasio, Fabio, Cozzio, Antonio, Flechsig, Eckhard, Rossi, Daniela, Klein, Michael A., Rülicke, Thomas, Raeber, Alex J., Christian A. J. Vosshenrich, Proft, Juliane, Aguzzi, Adriano, Weissmann, Charles

“…Prion replication in spleen and neuroinvasion after i.p. inoculation of mice is impaired in forms of immunodeficiency where mature B lymphocytes are lacking…”
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Prions and the lymphoreticular system by Dobson, C. M., Ellis, R. J., Fersht, A. R., Weissmann, Charles, Raeber, Alex J., Montrasio, Fabio, Hegyi, Ivan, Frigg, Rico, Klein, Michael A., Aguzzi, Adriano

“…Following intracerebral or peripheral inoculation of mice with scrapie prions, infectivity accumulates first in the spleen and only later in the brain. In the…”
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Transgenic and Knockout Mice in Research on Prion Diseases by Raeber, Alex J., Brandner, Sebastian, Klein, Michael A., Benninger, Yves, Musahl, Christine, Frigg, Rico, Roeckl, Christiane, Fischer, Michael B., Weissmann, Charles, Aguzzi, Adriano

“…Since the discovery of the prion protein (PrP) gene more than a decade ago, transgenetic investigations on the PrP gene have shaped the field of prion biology…”
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