Search Results - "Alex B. Valadka"

Magnetic resonance imaging improves 3-month outcome prediction in mild traumatic brain injury by Yuh, Esther L., Mukherjee, Pratik, Lingsma, Hester F., Yue, John K., Ferguson, Adam R., Gordon, Wayne A., Valadka, Alex B., Schnyer, David M., Okonkwo, David O., Maas, Andrew I. R., Manley, Geoffrey T.

“…Objective To determine the clinical relevance, if any, of traumatic intracranial findings on early head computed tomography (CT) and brain magnetic resonance…”
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Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats by Glushakova, Olena Y, Glushakov, Andriy O, Borlongan, Cesar V, Valadka, Alex B, Hayes, Ronald L, Glushakov, Alexander V

“…Traumatic brain injury (TBI) may be a significant risk factor for development of neurodegenerative disorders such as chronic traumatic encephalopathy (CTE),…”
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Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients by DeKosky, Steven T, Kochanek, Patrick M, Valadka, Alex B, Clark, Robert S B, Chou, Sherry H-Y, Au, Alicia K, Horvat, Christopher, Jha, Ruchira M, Mannix, Rebekah, Wisniewski, Stephen R, Wintermark, Max, Rowell, Susan E, Welch, Robert D, Lewis, Lawrence, House, Stacey, Tanzi, Rudolph E, Smith, Darci R, Vittor, Amy Y, Denslow, Nancy D, Davis, Michael D, Glushakova, Olena Y, Hayes, Ronald L

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus attacks multiple organs of coronavirus disease 2019 (COVID-19) patients, including the…”
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Diffusion tensor imaging for outcome prediction in mild traumatic brain injury: a TRACK-TBI study by Yuh, Esther L, Cooper, Shelly R, Mukherjee, Pratik, Yue, John K, Lingsma, Hester F, Gordon, Wayne A, Valadka, Alex B, Okonkwo, David O, Schnyer, David M, Vassar, Mary J, Maas, Andrew I R, Manley, Geoffrey T

“…We evaluated 3T diffusion tensor imaging (DTI) for white matter injury in 76 adult mild traumatic brain injury (mTBI) patients at the semiacute stage (11.2±3.3…”
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Circulating Brain-Derived Neurotrophic Factor Has Diagnostic and Prognostic Value in Traumatic Brain Injury by Korley, Frederick K, Diaz-Arrastia, Ramon, Wu, Alan H B, Yue, John K, Manley, Geoffrey T, Sair, Haris I, Van Eyk, Jennifer, Everett, Allen D, Okonkwo, David O, Valadka, Alex B, Gordon, Wayne A, Maas, Andrew I R, Mukherjee, Pratik, Yuh, Esther L, Lingsma, Hester F, Puccio, Ava M, Schnyer, David M

“…Brain-derived neurotrophic factor (BDNF) is important for neuronal survival and regeneration. We investigated the diagnostic and prognostic values of serum…”
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Age-Related Differences in Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein and Tau for Identifying Acute Intracranial Trauma on Computed Tomography: A TRACK-TBI Study by Gardner, Raquel C, Rubenstein, Richard, Wang, Kevin K W, Korley, Frederick K, Yue, John K, Yuh, Esther L, Mukherje, Pratik, Valadka, Alex B, Okonkwo, David O, Diaz-Arrastia, Ramon, Manley, Geoffrey T

“…Plasma tau and glial fibrillary acidic protein (GFAP) are promising biomarkers for identifying traumatic brain injury (TBI) patients with intracranial trauma…”
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Sub-classifying patients with mild traumatic brain injury: A clustering approach based on baseline clinical characteristics and 90-day and 180-day outcomes by Si, Bing, Dumkrieger, Gina, Wu, Teresa, Zafonte, Ross, Valadka, Alex B, Okonkwo, David O, Manley, Geoffrey T, Wang, Lujia, Dodick, David W, Schwedt, Todd J, Li, Jing

“…The current classification of traumatic brain injury (TBI) into "mild", "moderate", or "severe" does not adequately account for the patient heterogeneity that…”
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Natural History of Acute Subdural Hematoma by Vega, Rafael A., MD, PhD, Valadka, Alex B., MD

“…Because published guidelines for surgical decision-making in patients with acute subdural hematomas (ASDHs) are based largely on case series and other weak…”
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Editorial: Cerebral microdialysis by Chen, Jefferson W., Valadka, Alex B., Ross Bullock, M., Carpenter, Keri L. H.

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Chronic Upregulation of Cleaved-Caspase-3 Associated with Chronic Myelin Pathology and Microvascular Reorganization in the Thalamus after Traumatic Brain Injury in Rats by Glushakov, Andriy O, Glushakova, Olena Y, Korol, Tetyana Y, Acosta, Sandra A, Borlongan, Cesar V, Valadka, Alex B, Hayes, Ronald L, Glushakov, Alexander V

“…Traumatic brain injury (TBI) is associated with long-term disabilities and devastating chronic neurological complications including problems with cognition,…”
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Acute Management of Moderate-Severe Traumatic Brain Injury by Whitaker-Lea, Wittstatt Alexandra, MD, Valadka, Alex B., MD

“…Traumatic brain injury (TBI) continues to be a major public health problem. Proposed treatments have not withstood testing in clinical trials because of…”
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Variants of the endothelial nitric oxide gene and cerebral blood flow after severe traumatic brain injury by Robertson, Claudia S, Gopinath, Shankar P, Valadka, Alex B, Van, Mai, Swank, Paul R, Goodman, J Clay

“…Experimental studies suggest that nitric oxide produced by endothelial nitric oxide synthase (NOS3) plays a role in maintaining cerebral blood flow (CBF) after…”
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Prevention of secondary ischemic insults after severe head injury by Robertson, Claudia S, Valadka, Alex B, Hannay, H Julia, Contant, Charles F, Gopinath, Shankar P, Cormio, Manuela, Uzura, Masahiko, Grossman, Robert G

“…OBJECTIVE:The purpose of this study was to compare the effects of two acute-care management strategies on the frequency of jugular venous desaturation and…”
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Adult respiratory distress syndrome : a complication of induced hypertension after severe head injury by CONTANT, Charles F, VALADKA, Alex B, GOPINATH, Shankar P, HANNAY, H. Julia, ROBERTSON, Claudia S

“…The factors involved in the development of adult respiratory distress syndrome (ARDS) after severe head injury were studied. The presence of ARDS complicates…”
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ED disposition of the Glasgow Coma Scale 13 to 15 traumatic brain injury patient: analysis of the Transforming Research and Clinical Knowledge in TBI study by Ratcliff, Jonathan J., MD, MPH, Adeoye, Opeolu, MD, MS, Lindsell, Christopher J., PhD, Hart, Kimberly W., MA, Pancioli, Arthur, MD, McMullan, Jason T., MD, Yue, John K., BS, Nishijima, Daniel K., MD, Gordon, Wayne A., PhD, Valadka, Alex B., MD, Okonkwo, David O., MD, PhD, Lingsma, Hester F., PhD, Maas, Andrew I.R., MD, PhD, Manley, Geoffrey T., MD PhD

“…Abstract Objective Mild traumatic brain injury (mTBI) patients are frequently admitted to high levels of care despite limited evidence suggesting benefit. Such…”
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Patterns of energy substrates during ischemia measured in the brain by microdialysis by Hlatky, Roman, Valadka, Alex B, Goodman, J Clay, Contant, Charles F, Robertson, Claudia S

“…The purpose of this study was to examine the patterns of change in microdialysate concentrations of glucose, lactate, pyruvate, and glutamate in the brain…”
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Relationship of brain tissue PO2 to outcome after severe head injury by Valadka, Alex B, Gopinath, Shankar P, Contant, Charles F, Uzura, Masahiko, Robertson, Claudia S

“…OBJECTIVETo determine thresholds of brain tissue PO2 (PbtO2) that are critical for survival after severe head injury. DESIGNProspective data collection…”
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Use of MRI in patients with severe diffuse traumatic brain injury: A matched National Trauma Data Bank analysis by Chilakapati, Sai, Dragun, Anthony J, Chiu, Ryan G, George, Keith M, Valadka, Alex B

“…Magnetic resonance imaging (MRI) is increasingly used to evaluate patients with diffuse traumatic brain injury (dTBI). However, the utility of early MRI is…”
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Professional conduct oversight in neurosurgery by Bean, James R, Valadka, Alex B, Knape, Frederic T

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Symptomatology and functional outcome in mild traumatic brain injury: results from the prospective TRACK-TBI study by McMahon, Paul, Hricik, Allison, Yue, John K, Puccio, Ava M, Inoue, Tomoo, Lingsma, Hester F, Beers, Sue R, Gordon, Wayne A, Valadka, Alex B, Manley, Geoffrey T, Okonkwo, David O

“…Mild Traumatic Brain Injury (mTBI), or concussion, is a major public health concern. There is controversy in the literature regarding the true incidence of…”
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