Search Results - "Alex, A."

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor by Zhao, Yujie, Adjei, Alex A.

“…Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during human development and reproduction; however, aberrant regulation of…”
Get full text

KRAS: From undruggable to a druggable Cancer Target by Uprety, Dipesh, Adjei, Alex A.

“…•RAS is the most frequently mutated oncogene in human cancers, accounting for approximately 30% of mutations in all human cancers.•Despite playing a distinct…”
Get full text

Lessons in self-defence: inhibition of virus entry by intrinsic immunity by Majdoul, Saliha, Compton, Alex A.

“…Virus entry, consisting of attachment to and penetration into the host target cell, is the first step of the virus life cycle and is a critical ‘do or die’…”
Get full text

The clinical development of MEK inhibitors by Zhao, Yujie, Adjei, Alex A.

“…Key Points MEK1/2 have crucial roles in mediating cellular signals transduced from RAS–RAF, an oncogenic pathway implicated in numerous types of tumour, and…”
Get full text

Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells by Nowakowski, Tomasz J., Pollen, Alex A., Di Lullo, Elizabeth, Sandoval-Espinosa, Carmen, Bershteyn, Marina, Kriegstein, Arnold R.

“…The recent outbreak of Zika virus (ZIKV) in Brazil has been linked to substantial increases in fetal abnormalities and microcephaly. However, information about…”
Get full text

Continuous dynamic adjustment of the plant circadian oscillator by Webb, Alex A. R., Seki, Motohide, Satake, Akiko, Caldana, Camila

“…The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana . The circadian oscillator is an important…”
Get full text

Crosslinking effect on polydimethylsiloxane elastic modulus measured by custom-built compression instrument by Wang, Zhixin, Volinsky, Alex A., Gallant, Nathan D.

“…ABSTRACT A macroscopic compression test utilizing a simple custom‐built instrument was employed to measure polydimethylsiloxane (PDMS) elastic modulus. PDMS…”
Get full text

Transformation of the Radial Glia Scaffold Demarcates Two Stages of Human Cerebral Cortex Development by Nowakowski, Tomasz J., Pollen, Alex A., Sandoval-Espinosa, Carmen, Kriegstein, Arnold R.

“…The classic view of cortical development, embodied in the radial unit hypothesis, highlights the ventricular radial glia (vRG) scaffold as a key architectonic…”
Get full text

Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution by Pollen, Alex A., Kilik, Umut, Lowe, Craig B., Camp, J. Gray

“…Our ancestors acquired morphological, cognitive and metabolic modifications that enabled humans to colonize diverse habitats, develop extraordinary…”
Get full text

Lung Cancer Worldwide by Adjei, Alex A

Get more information

Review of recent developments (2018–2020) on acetylcholinesterase inhibition based biosensors for organophosphorus pesticides detection by Vinotha Alex, A., Mukherjee, Amitava

“…•Recent advances on AChE based OPs sensing strategies/devices are described.•Patents and commercially available OPs detection kits are reviewed.•Merits and…”
Get full text

An ultrasensitive "mix-and-detect" kind of fluorescent biosensor for malaoxon detection using the AChE-ATCh-Ag-GO system by Alex. A, Vinotha, Mukherjee, Amitava

“…Malaoxon, a highly toxic metabolite of malathion, can lead to severe harm or death if ingested. This study introduces a rapid and innovative fluorescent…”
Get full text

Current Diagnosis and Management of Small-Cell Lung Cancer by Wang, Shuhang, Zimmermann, Stefan, Parikh, Kaushal, Mansfield, Aaron S., Adjei, Alex A.

“…Small-cell lung cancer (SCLC) is an aggressive disease with distinct pathological, clinical, and molecular characteristics from non–small-cell lung cancer…”
Get full text

Anthropocene, Capitalocene, … Plantationocene?: A Manifesto for Ecological Justice in an Age of Global Crises by Davis, Janae, Moulton, Alex A., Van Sant, Levi, Williams, Brian

“…The “Plantationocene” has gained traction in the environmental humanities as a way of conceptualizing the current era otherwise nominated as the Anthropocene,…”
Get full text

An extensive evaluation of seven machine learning methods for rainfall prediction in weather derivatives by Cramer, Sam, Kampouridis, Michael, Freitas, Alex A., Alexandridis, Antonis K.

“…•An extensive evaluation of machine learning methods.•Predictive performance not affected between Europe and the USA.•Some linear relationships exists between…”
Get full text

Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO2: Observations from high-resolution T2 weighted imaging at 7T by Bhogal, Alex A.

“…•Hemodynamic parameter mapping using 7 T BOLD-MRI with CO2 challenge.•Spatial correlation of hemodynamic responses with venous vascular architecture.•BOLD…”
Get full text

Photosynthetic entrainment of the Arabidopsis thaliana circadian clock by Haydon, Michael J., Mielczarek, Olga, Robertson, Fiona C., Hubbard, Katharine E., Webb, Alex A. R.

“…In Arabidopsis thaliana , the rhythm of sugar production by photosynthesis sets the timing of the circadian clock, by regulating the expression of circadian…”
Get full text

Molecular Identity of Human Outer Radial Glia during Cortical Development by Pollen, Alex A., Nowakowski, Tomasz J., Chen, Jiadong, Retallack, Hanna, Sandoval-Espinosa, Carmen, Nicholas, Cory R., Shuga, Joe, Liu, Siyuan John, Oldham, Michael C., Diaz, Aaron, Lim, Daniel A., Leyrat, Anne A., West, Jay A., Kriegstein, Arnold R.

“…Radial glia, the neural stem cells of the neocortex, are located in two niches: the ventricular zone and outer subventricular zone. Although outer…”
Get full text

A survey of hierarchical classification across different application domains by Silla, Carlos N., Freitas, Alex A.

“…In this survey we discuss the task of hierarchical classification. The literature about this field is scattered across very different application domains and…”
Get full text

MET: a promising anticancer therapeutic target by Peters, Solange, Adjei, Alex A.

“…Targeting the MET pathway is an increasingly attractive anticancer strategy. In this Review, this pathway is viewed from the clinical perspective, assessing…”
Get full text