Search Results - "Alevizopoulos, Konstantinos"

Na+/K+ ATPase inhibitors in cancer by Alevizopoulos, Konstantinos, Calogeropoulou, Theodora, Lang, Florian, Stournaras, Christos

“…Sodium potassium pump (Na(+)/K(+) ATPase) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining…”
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Membrane Androgen Receptor Down-Regulates c-Src-Activity and Beta-Catenin Transcription and Triggers GSK-3beta-Phosphorylation in Colon Tumor Cells by Gu, Shuchen, Honisch, Sabina, Kounenidakis, Michalis, Alkahtani, Saad, Alarifi, Saud, Alevizopoulos, Konstantinos, Stournaras, Christos, Lang, Florian

“…Background/Aims: Functional membrane androgen receptors (mARs) have recently been described in colon tumor cells and tissues. Their activation by specific…”
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Activation of membrane androgen receptors in colon cancer inhibits the prosurvival signals Akt/bad in vitro and in vivo and blocks migration via vinculin/actin signaling by Gu, Shuchen, Papadopoulou, Natalia, Nasir, Omaima, Föller, Michael, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Recently, we reported that membrane androgen receptors (mARs) are expressed in colon tumors triggering strong apoptotic responses. In the present study, we…”
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Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes by Mitsias, Dimitrios I., Dimou, Maria V., Lakoumentas, John, Alevizopoulos, Konstantinos, Sousa‐Pinto, Bernardo, Fonseca, Joao A., Bousquet, Jean, Papadopoulos, Nikolaos G.

“…Background Nasal irrigations (NI) are increasingly used as an over‐the‐counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their…”
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Membrane androgen receptor activation in prostate and breast tumor cells: Molecular signaling and clinical impact by Papadopoulou, Natalia, Papakonstanti, Evangelia A., Kallergi, Galatea, Alevizopoulos, Konstantinos, Stournaras, Christos

“…In recent years, membrane androgen receptors (mARs) have been identified in prostate and breast tumor cells, and their activation by specific mAR ligands was…”
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Istaroxime Inhibits Motility and Down-Regulates Orai1 Expression, SOCE and FAK Phosphorylation in Prostate Cancer Cells by Stagno, Matias Julian, Zacharopoulou, Nefeli, Bochem, Jonas, Tsapara, Anna, Pelzl, Lisann, al-Maghout, Tamer, Kallergi, Galatea, Alkahtani, Saad, Alevizopoulos, Konstantinos, Dimas, Konstantinos, Calogeropoulou, Theodora, Warmann, Steven W., Lang, Florian, Schmid, Evi, Stournaras, Christos

“…Abstract Background/Aims: Istaroxime is a validated inotropic Na+/K+ ATPase inhibitor currently in development for the treatment of various cardiac conditions…”
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Functional membrane androgen receptors in colon tumors trigger pro-apoptotic responses in vitro and reduce drastically tumor incidence in vivo by Gu, Shuchen, Papadopoulou, Natalia, Gehring, Eva-Maria, Nasir, Omaima, Dimas, Konstantinos, Bhavsar, Shefalee K, Föller, Michael, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Membrane androgen receptors (mAR) have been implicated in the regulation of cell growth, motility and apoptosis in prostate and breast cancer. Here we analyzed…”
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Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo by Dimas, Konstantinos, Papadopoulou, Natalia, Baskakis, Constantinos, Prousis, Kyriakos C, Tsakos, Michail, Alkahtani, Saad, Honisch, Sabina, Lang, Florian, Calogeropoulou, Theodora, Alevizopoulos, Konstantinos, Stournaras, Christos

“…Sodium potassium pump (Na(+)/K(+)ATPase) is a validated pharmacological target for the treatment of congestive heart failure. Recent data with inotropic drugs…”
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Membrane androgen receptor activation triggers down-regulation of PI-3K/Akt/NF-kappaB activity and induces apoptotic responses via Bad, FasL and caspase-3 in DU145 prostate cancer cells by Papadopoulou, Natalia, Charalampopoulos, Ioannis, Anagnostopoulou, Vasileia, Konstantinidis, Georgios, Föller, Michael, Gravanis, Achilleas, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Recently we have reported membrane androgen receptors-induced apoptotic regression of prostate cancer cells regulated by Rho/ROCK/actin signaling. In the…”
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Mutations Leading to X-linked Hypohidrotic Ectodermal Dysplasia Affect Three Major Functional Domains in the Tumor Necrosis Factor Family Member Ectodysplasin-A by Schneider, Pascal, Street, Summer L., Gaide, Olivier, Hertig, Sylvie, Tardivel, Aubry, Tschopp, Jürg, Runkel, Laura, Alevizopoulos, Konstantinos, Ferguson, Betsy M., Zonana, Jonathan

“…Mutations in the epithelial morphogen ectodysplasin-A (EDA), a member of the tumor necrosis factor (TNF) family, are responsible for the human disorder…”
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A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells by Honisch, Sabina, Alkahtani, Saad, Kounenidakis, Michalis, Liu, Guilai, Alarifi, Saud, Al-Yahya, Hamad, Dimas, Konstantinos, AlKahtane, Abdullah A, Prousis, Kyriakos C, Al-Dahmash, Bader, Calogeropoulou, Theodora, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Recently we have reported potent anti-cancer actions of various steroidal Na(+)/K(+) ATPase inhibitors in multiple cell lines. Furthermore, the most powerful…”
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Recruitment of TRRAP required for oncogenic transformation by E1A by DELEU, Laurent, SHELLARD, Sharon, ALEVIZOPOULOS, Konstantinos, AMATI, Bruno, LAND, Hartmut

“…TRRAP links Myc with histone acetylases and appears to be an important mediator of its oncogenic function. Here we show that interaction with TRRAP is required…”
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ATX-101, a cell-penetrating protein targeting PCNA, can be safely administered as intravenous infusion in patients and shows clinical activity in a Phase 1 study by Lemech, Charlotte Rose, Kichenadasse, Ganessan, Marschner, Jens-Peter, Alevizopoulos, Konstantinos, Otterlei, Marit, Millward, Michael

“…Proliferating Cell Nuclear Antigen (PCNA) is a highly conserved protein essential for DNA replication, repair and scaffold functions in the cytosol. Specific…”
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Targeting membrane androgen receptors in tumors by Lang, Florian, Alevizopoulos, Konstantinos, Stournaras, Christos

“…In the last decade androgen actions that are originated from non-genomic, rapid signaling have been described in a large number of cell models and tissues…”
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Conserved region 2 of adenovirus E1A has a function distinct from pRb binding required to prevent cell cycle arrest by p16ink4a or p27Kip1 by ALEVIZOPOULOS, K, SANCHEZ, B, AMATI, B

“…Ectopic expression of the CDK inhibitors (CKIs) p16INK4a and p27Kip1 in Rat1 fibroblasts induces dephosphorylation and activation of Retinoblastoma-family…”
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The effect of nasal douching by hypertonic 2.3 per cent sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment by Perić, Aleksandar, Gaćeša, Dejan, Kovačević, Sandra Vezmar, Perić, Aneta V, Vojvodić, Danilo, Georgiou, Stella, Protopapadakis, Evdokia, Alevizopoulos, Konstantinos

“…To investigate epidermal growth factor, transforming growth factor-α and interleukin-8 production in nasal mucosa irrigated with hypertonic 2.3 per cent…”
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Rapid activation of FAK/mTOR/p70S6K/PAK1-signaling controls the early testosterone-induced actin reorganization in colon cancer cells by Gu, Shuchen, Kounenidakis, Michalis, Schmidt, Eva-Maria, Deshpande, Divija, Alkahtani, Saad, Alarifi, Saud, Föller, Michael, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Actin cytoskeleton reorganization initiated by testosterone conjugates through activation of membrane androgen receptors (mAR) has recently been reported in…”
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The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action by Mahaira, Louisa G., Tsimplouli, Chrisiida, Sakellaridis, Nikos, Alevizopoulos, Konstantinos, Demetzos, Costas, Han, Zhiyong, Pantazis, Panayotis, Dimas, Konstantinos

“…The labdane diterpene sclareol has demonstrated significant cytotoxicity against human tumor cell lines and human colon cancer xenografts. Therefore, there is…”
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Serum‐ and glucocorticoid‐dependent kinase‐1‐induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor by Schmidt, Eva‐Maria, Gu, Shuchen, Anagnostopoulou, Vasileia, Alevizopoulos, Konstantinos, Föller, Michael, Lang, Florian, Stournaras, Christos

“…The serum‐ and glucocorticoid‐dependent kinases 1–3 (SGK1–3) are downstream effectors of phosphatidylinositol 3‐kinases, implicated in various cell responses…”
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Abstract 1728: Membrane androgen receptor ligands: a novel therapeutic approach for the treatment of cancer by Alevizopoulos, Konstantinos, Bacopoulos, Nicholas G., Stournaras, Christos

“…Abstract Membrane Androgen Receptor (mAR) is a novel, yet of unknown identity, membrane receptor frequently over-expressed in aggressive prostate cancer. mAR…”
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