Search Results - "Alessio Nencioni"

Fasting and cancer: molecular mechanisms and clinical application by Nencioni, Alessio, Caffa, Irene, Cortellino, Salvatore, Longo, Valter D.

“…The vulnerability of cancer cells to nutrient deprivation and their dependency on specific metabolites are emerging hallmarks of cancer. Fasting or…”
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Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers by Di Tano, Maira, Raucci, Franca, Vernieri, Claudio, Caffa, Irene, Buono, Roberta, Fanti, Maura, Brandhorst, Sebastian, Curigliano, Giuseppe, Nencioni, Alessio, de Braud, Filippo, Longo, Valter D.

“…Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with…”
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Vitamin C, Aging and Alzheimer's Disease by Monacelli, Fiammetta, Acquarone, Erica, Giannotti, Chiara, Borghi, Roberta, Nencioni, Alessio

“…Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid…”
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Advances in NAD-Lowering Agents for Cancer Treatment by Ghanem, Moustafa S, Monacelli, Fiammetta, Nencioni, Alessio

“…Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor, but it also acts as a substrate for NAD-consuming enzymes, regulating cellular events…”
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Extracellular nicotinamide phosphoribosyltransferase: role in disease pathophysiology and as a biomarker by Semerena, Elise, Nencioni, Alessio, Masternak, Krzysztof

“…Nicotinamide phosphoribosyltransferase (NAMPT) plays a central role in mammalian cell metabolism by contributing to nicotinamide adenine dinucleotide…”
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Fasting-mimicking diet and hormone therapy induce breast cancer regression by Caffa, Irene, Spagnolo, Vanessa, Vernieri, Claudio, Valdemarin, Francesca, Becherini, Pamela, Wei, Min, Brandhorst, Sebastian, Zucal, Chiara, Driehuis, Else, Ferrando, Lorenzo, Piacente, Francesco, Tagliafico, Alberto, Cilli, Michele, Mastracci, Luca, Vellone, Valerio G., Piazza, Silvano, Cremonini, Anna Laura, Gradaschi, Raffaella, Mantero, Carolina, Passalacqua, Mario, Ballestrero, Alberto, Zoppoli, Gabriele, Cea, Michele, Arrighi, Annalisa, Odetti, Patrizio, Monacelli, Fiammetta, Salvadori, Giulia, Cortellino, Salvatore, Clevers, Hans, De Braud, Filippo, Sukkar, Samir G., Provenzani, Alessandro, Longo, Valter D., Nencioni, Alessio

“…Approximately 75% of all breast cancers express the oestrogen and/or progesterone receptors. Endocrine therapy is usually effective in these…”
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Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair by Piacente, Francesco, Caffa, Irene, Ravera, Silvia, Sociali, Giovanna, Passalacqua, Mario, Vellone, Valerio G, Becherini, Pamela, Reverberi, Daniele, Monacelli, Fiammetta, Ballestrero, Alberto, Odetti, Patrizio, Cagnetta, Antonia, Cea, Michele, Nahimana, Aimable, Duchosal, Michel, Bruzzone, Santina, Nencioni, Alessio

“…In the last decade, substantial efforts have been made to identify NAD biosynthesis inhibitors, specifically against nicotinamide phosphoribosyltransferase…”
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Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment by Khalifa, Amr, Guijarro, Ana, Nencioni, Alessio

“…There is currently a growing interest in diets and physical activity patterns that may be beneficial in preventing and treating breast cancer (BC). Mounting…”
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Fasting and Cognitive Impairment by Tagliafico, Luca, Nencioni, Alessio, Monacelli, Fiammetta

“…Fasting is a nutritional practice involving complete food restriction for a varying length of time [...]…”
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Inhibitors of NAD + Production in Cancer Treatment: State of the Art and Perspectives by Ghanem, Moustafa S, Caffa, Irene, Monacelli, Fiammetta, Nencioni, Alessio

“…The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD ) levels is a hallmark of cancer metabolism. Obstructing NAD biosynthesis in tumors…”
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TLR activation of tumor‐associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells by Bellora, Francesca, Castriconi, Roberta, Dondero, Alessandra, Pessino, Anna, Nencioni, Alessio, Liggieri, Giovanni, Moretta, Lorenzo, Mantovani, Alberto, Moretta, Alessandro, Bottino, Cristina

“…We analyzed the functional outcome of the interaction between tumor‐associated macrophages (TAMs) and natural killer (NK) cells. TAMs from ascites of ovarian…”
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Pathophysiological role of neutrophils in acute myocardial infarction by Carbone, F, Nencioni, A, Mach, F, Vuilleumier, N, Montecucco, F

“…The pathogenesis of acute myocardial infarction is known to be mediated by systemic, intraplaque and myocardial inflammatory processes. Among different immune…”
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Social vulnerability underlying disability amongst older adults: A systematic review by Cappelli, Miriam, Bordonali, Alessandro, Giannotti, Chiara, Montecucco, Fabrizio, Nencioni, Alessio, Odetti, Patrizio, Monacelli, Fiammetta

“…Background Older adults face radical changes in their social life during ageing, dealing with several age‐related social adaptations. The aim of this review is…”
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Reply to ‘Fasting in oncology: a word of caution’ by Nencioni, Alessio, Caffa, Irene, Cortellino, Salvatore, Longo, Valter D.

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Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells by Cea, Michele, Cagnetta, Antonia, Adamia, Sophia, Acharya, Chirag, Tai, Yu-Tzu, Fulciniti, Mariateresa, Ohguchi, Hiroto, Munshi, Aditya, Acharya, Prakrati, Bhasin, Manoj K., Zhong, Lei, Carrasco, Ruben, Monacelli, Fiammetta, Ballestrero, Alberto, Richardson, Paul, Gobbi, Marco, Lemoli, Roberto M., Munshi, Nikhil, Hideshima, Teru, Nencioni, Alessio, Chauhan, Dharminder, Anderson, Kenneth C.

“…Multiple myeloma (MM) is characterized by a highly unstable genome, with aneuploidy observed in nearly all patients. The mechanism causing this karyotypic…”
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Pharmacological Sirt6 inhibition improves glucose tolerance in a type 2 diabetes mouse model by Sociali, Giovanna, Magnone, Mirko, Ravera, Silvia, Damonte, Patrizia, Vigliarolo, Tiziana, Von Holtey, Maria, Vellone, Valerio G., Millo, Enrico, Caffa, Irene, Cea, Michele, Daniele Parenti, Marco, Del Rio, Alberto, Murone, Maximilien, Mostoslavsky, Raul, Grozio, Alessia, Nencioni, Alessio, Bruzzone, Santina

“…ABSTRACT Sirtuin 6 (SIRT6) is a sirtuin family member involved in a wide range of physiologic and disease processes, including cancer and glucose homeostasis…”
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The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses by Bauer, Inga, Grozio, Alessia, Lasigliè, Denise, Basile, Giovanna, Sturla, Laura, Magnone, Mirko, Sociali, Giovanna, Soncini, Debora, Caffa, Irene, Poggi, Alessandro, Zoppoli, Gabriele, Cea, Michele, Feldmann, Georg, Mostoslavsky, Raul, Ballestrero, Alberto, Patrone, Franco, Bruzzone, Santina, Nencioni, Alessio

“…Cytokine secretion by cancer cells contributes to cancer-induced symptoms and angiogenesis. Studies show that the sirtuin SIRT6 promotes inflammation by…”
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Sirt6 inhibition delays the onset of experimental autoimmune encephalomyelitis by reducing dendritic cell migration by Ferrara, Giovanni, Benzi, Andrea, Sturla, Laura, Marubbi, Daniela, Frumento, Davide, Spinelli, Sonia, Abbotto, Elena, Ivaldi, Federico, von Holtey, Maria, Murone, Maximilien, Nencioni, Alessio, Uccelli, Antonio, Bruzzone, Santina

“…Abstract Background Experimental autoimmune encephalomyelitis (EAE) is the most common animal model of multiple sclerosis (MS), a neuroinflammatory and…”
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Gut microbiota severely hampers the efficacy of NAD-lowering therapy in leukemia by ElMokh, Oussama, Matsumoto, Saki, Biniecka, Paulina, Bellotti, Axel, Schaeuble, Karin, Piacente, Francesco, Gallart-Ayala, Hector, Ivanisevic, Julijana, Stamenkovic, Ivan, Nencioni, Alessio, Nahimana, Aimable, Duchosal, Michel A.

“…Most cancer cells have high need for nicotinamide adenine dinucleotide (NAD + ) to sustain their survival. This led to the development of inhibitors of…”
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Cyclic fasting bolsters cholesterol biosynthesis inhibitors’ anticancer activity by Khalifa, Amr, Guijarro, Ana, Ravera, Silvia, Bertola, Nadia, Adorni, Maria Pia, Papotti, Bianca, Raffaghello, Lizzia, Benelli, Roberto, Becherini, Pamela, Namatalla, Asmaa, Verzola, Daniela, Reverberi, Daniele, Monacelli, Fiammetta, Cea, Michele, Pisciotta, Livia, Bernini, Franco, Caffa, Irene, Nencioni, Alessio

“…Identifying oncological applications for drugs that are already approved for other medical indications is considered a possible solution for the increasing…”
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