Search Results - "Alessia Ciogli"
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Advances in Transition Metal Catalysis—Preface to the Special Issue
Published in Catalysts (01-07-2024)“…Over the years, transition metal catalysis has had a significant impact on science and technology [...]…”
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Remote Control of Axial Chirality: Aminocatalytic Desymmetrization of N‑Arylmaleimides via Vinylogous Michael Addition
Published in Journal of the American Chemical Society (23-07-2014)“…Remote control of the axial chirality of N-(2-t-butylphenyl)succinimides was realized via the vinylogous Michael addition of 3-substituted cyclohexenones to…”
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Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram
Published in Journal of separation science (01-03-2018)“…The ever‐increasing need for enantiomerically pure chiral compounds has greatly expanded the number of enantioselective separation methods available for the…”
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Organocatalytic Atroposelective Formal Diels–Alder Desymmetrization of N‑Arylmaleimides
Published in Organic letters (03-04-2015)“…The atroposelective desymmetrization of N-arylmaleimides was realized by means of a primary amine catalyzed Diels–Alder reaction of enones. The chiral axis as…”
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Pirkle-type chiral stationary phase on core–shell and fully porous particles: Are superficially porous particles always the better choice toward ultrafast high-performance enantioseparations?
Published in Journal of Chromatography A (30-09-2016)“…•Novel Pirkle-type Whelk-O1 core–shell chiral stationary phase was prepared.•Difficulty of efficiently packing polar core–shell particles is reported.•Effect…”
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6
Salivary caffeine in Parkinson’s disease
Published in Scientific reports (10-05-2021)“…We aimed to investigate salivary caffeine content, caffeine absorption and metabolism in Parkinson’s disease (PD) and verify whether salivary caffeine can be…”
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Diaryl-Pyrano-Chromenes Atropisomers: Stereodynamics and Conformational Studies
Published in Molecules (Basel, Switzerland) (22-06-2023)“…The dynamic scenario of di-aryls-pyrano-chromenes was investigated using DFT calculations. The symmetry of the chromene scaffold and the presence of two…”
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Dynamic high performance liquid chromatography on chiral stationary phases. Low temperature separation of the interconverting enantiomers of diazepam, flunitrazepam, prazepam and tetrazepam
Published in Journal of Chromatography A (10-10-2014)“…•The conformational enantiomers of diazepam were resolved by cryo-HPLC on Whelk-O1.•Prazepam, tetrazepam and flunitrazepam were also resolved on the Whelk-O1…”
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Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine
Published in International journal of molecular sciences (25-12-2020)“…The presence of stereogenic elements is a common feature in pharmaceutical compounds, and affording optically pure stereoisomers is a frequent issue in drug…”
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Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies
Published in International journal of molecular sciences (19-07-2022)“…Human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms IX and XII are overexpressed in solid hypoxic tumors, and they are considered as prognostic tools and…”
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On the Nature of the Rotational Energy Barrier of Atropisomeric Hydrazides
Published in Molecules (Basel, Switzerland) (29-11-2023)“…N-N atropisomers represent a useful class of compounds that has recently received important attention from many research groups. This article presents an…”
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Effect of Natural Deep Eutectic Solvents on trans -Resveratrol Photo-Chemical Induced Isomerization and 2,4,6-Trihydroxyphenanthrene Electro-Cyclic Formation
Published in Molecules (Basel, Switzerland) (06-04-2022)“…-Resveratrol is a natural bioactive compound with well-recognized health promoting effects. When exposed to UV light, this compound can undergo a…”
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Asymmetric Hydroarylation Reactions Catalyzed by Transition Metals: Last 10 Years in a Mini Review
Published in Catalysts (01-10-2022)“…Hydroarylation reactions play a pivotal role in organic chemistry due to their versatility and efficiency. In the last 10 years, the scientific production…”
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Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2018)“…This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling…”
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A Compendium of the Principal Stationary Phases Used in Hydrophilic Interaction Chromatography: Where Have We Arrived?
Published in Separations (01-01-2023)“…Hydrophilic interaction liquid chromatography (HILIC) today is a well-known and largely applied technique to analyse polar compounds such as pharmaceuticals,…”
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Static vs. Dynamic Electrostatic Repulsion Reversed Phase Liquid Chromatography: Solutions for Pharmaceutical and Biopharmaceutical Basic Compounds
Published in Separations (01-05-2021)“…Many efforts have been made to separate basic compounds, which are challenging to resolve in reversed phase liquid chromatography. In this process, they are…”
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Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells
Published in European journal of medicinal chemistry (01-02-2019)“…In aggressive tumors, alkylglyceronephosphate synthase (AGPS) controls cellular ether phospholipid utilization and metabolism to promote cancer cell…”
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Enantioselective ultra-high and high performance liquid chromatography: A comparative study of columns based on the Whelk-O1 selector
Published in Journal of Chromatography A (21-12-2012)“…► The Whelk-O1 selector was covalently immobilized onto 1.7-μm porous silica particles. ► A UHPLC 100mm×4.6mm column generated more than 265000N/m for chiral…”
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Separation of complex sugar mixtures on a hydrolytically stable bidentate urea-type stationary phase for hydrophilic interaction near ultra high performance liquid chromatography
Published in Journal of separation science (01-03-2014)“…A stationary phase bearing both bridged bis‐ureido and free amino groups (USP‐HILIC‐NH2–2.5SP) for high‐speed hydrophilic interaction liquid chromatography…”
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Valorization of By-Products from Biofuel Biorefineries: Extraction and Purification of Bioactive Molecules from Post-Fermentation Corn Oil
Published in Foods (07-01-2022)“…The aim of this work was to develop innovative and sustainable extraction, concentration, and purification technologies aimed to recover target substances from…”
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