Effects of "Bacuri" Seed Butter ( Platonia insignis Mart.), a Brazilian Amazon Fruit, on Oxidative Stress and Diabetes Mellitus-Related Parameters in STZ-Diabetic Rats

This study aimed to investigate the effects of oral administration of Mart. ("bacuri") seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180-250 g) by the intrap...

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Published in:	Biology (Basel, Switzerland) Vol. 11; no. 4; p. 562
Main Authors:	Lindoso, Jéssica Vanessa Dos Santos, Alencar, Salmon Rocha, Santos, Andressa Amorim Dos, Mello Neto, Renato Sampaio, Mendes, Ana Victória da Silva, Furtado, Mariely Mendes, Silva, Maisa Gomes da, Brito, Ana Karolinne da Silva, Batista, Emanuelle Karine Frota, Baêta, Silvia de Araújo França, Moreira Nunes, Paulo Humberto, Lucarini, Massimo, Durazzo, Alessandra, Arcanjo, Daniel Dias Rufino, Martins, Maria do Carmo de Carvalho E
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 07-04-2022 MDPI
Subjects:	Animals antioxidant activity Antioxidants bacuri Biomarkers Body weight gain Clusiaceae Diabetes Diabetes mellitus Food Food intake Glucose Glucose metabolism Hemoglobin hepatoprotection Hyperglycemia Insulin Investigations Kidneys Liver Metabolic disorders Metabolic pathways Natural products Oral administration Oxidative stress Plasma Platonia Seeds Statistical analysis Streptozocin Sulfhydryl groups Variance analysis Brazil bacuri Clusiaceae diabetes mellitus antioxidant activity hepatoprotection
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Summary:	This study aimed to investigate the effects of oral administration of Mart. ("bacuri") seed butter (BSB) on oxidative stress and diabetes mellitus-related parameters in streptozotocin-induced (STZ) diabetic rats. Diabetes mellitus was induced in female Wistar rats (180-250 g) by the intraperitoneal administration of STZ (45 mg/kg, b.w). BSB (25, 50, and 100 mg/kg) was administered to animals for four weeks. The effect on weight gain, food intake, blood glucose, glycated hemoglobin, hepatic transaminases, plasma and liver TBARS and MPO activity, erythrocyte SOD activity, non-protein sulfhydryl groups (SH-NP), and histopathology of the liver tissue was investigated. BSB at the dose of 100 mg/kg had a positive effect on the reduction in glycated hemoglobin percentage and increased albumin concentration, as well as decreased ALT and AST levels and increased SH-NP liver levels in treated animals compared to normal control rats. Moreover, BSB had no effects on weight gain, food intake, and fasting glucose. Thus, the BSB presented marked properties in improvement of hepatic antioxidant defenses, which demonstrates BSB as a potential hepatoprotective agent in metabolic disorders.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2079-7737 2079-7737
DOI:	10.3390/biology11040562