Search Results - "Alemi, Mobina"
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Transthyretin participates in beta-amyloid transport from the brain to the liver- involvement of the low-density lipoprotein receptor-related protein 1?
Published in Scientific reports (03-02-2016)“…Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD…”
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Transthyretin stability is critical in assisting beta amyloid clearance– Relevance of transthyretin stabilization in Alzheimer's disease
Published in CNS neuroscience & therapeutics (01-07-2017)“…Summary Background The absence of transthyretin (TTR) in AD mice decreases brain Aβ clearance and reduces the low‐density lipoprotein receptor‐related protein…”
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Exploring the Physiological Role of Transthyretin in Glucose Metabolism in the Liver
Published in International journal of molecular sciences (04-06-2021)“…Transthyretin (TTR), a 55 kDa evolutionarily conserved protein, presents altered levels in several conditions, including malnutrition, inflammation, diabetes,…”
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Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD
Published in Scientific reports (20-09-2019)“…It is well settled that the amyloidogenic properties of the plasma protein transporter transthyretin (TTR) can be modulated by compounds that stabilize its…”
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Resveratrol administration increases Transthyretin protein levels ameliorating AD features- importance of transthyretin tetrameric stability
Published in Molecular medicine (Cambridge, Mass.) (01-01-2016)“…Previous in vivo work showed that resveratrol has beneficial effects in the AD pathology, resulting in increased expression of transthyretin (TTR). TTR binds…”
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Dynamics of Lateral Habenula–Ventral Tegmental Area Microcircuit on Pain-Related Cognitive Dysfunctions
Published in Neurology international (01-10-2023)“…Chronic pain is a health problem that affects the ability to work and perform other activities, and it generally worsens over time. Understanding the complex…”
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Role of Glutamatergic Projections from Lateral Habenula to Ventral Tegmental Area in Inflammatory Pain-Related Spatial Working Memory Deficits
Published in Biomedicines (01-03-2023)“…The lateral habenula (LHb) and the ventral tegmental area (VTA), which form interconnected circuits, have important roles in the crucial control of sensory and…”
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Anti-inflammatory Effect of Seeds and Callus of Nigella sativa L. Extracts on Mix Glial Cells with Regard to Their Thymoquinone Content
Published in AAPS PharmSciTech (01-03-2013)“…Anti-inflammatory effect of the alcoholic extracts of N. sativa seeds and its callus on mix glial cells of rat with regard to their thymoquinone (TQ) content…”
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Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal
Published in Journal of medicinal chemistry (13-07-2017)“…Several strategies against Alzheimer disease (AD) are directed to target Aβ-peptides. The ability of transthyretin (TTR) to bind Aβ-peptides and the positive…”
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Collagen type IV in brain vessels of an AD mouse model: modulation by transthyretin?
Published in Amyloid (29-03-2019)Get full text
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The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
Published in Science advances (01-06-2018)“…Amyloid-β (Aβ) aggregation and neuroinflammation are consistent features in Alzheimer's disease (AD) and strong candidates for the initiation of…”
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