Search Results - "Aleluia, Milena"
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Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)
Published in PloS one (29-01-2020)“…Sickle cell disease (SCD) consists of a group of hemoglobinopathies in which individuals present highly variable clinical manifestations. Sickle cell anemia…”
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Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers
Published in PloS one (04-02-2021)“…Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to…”
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3
Hydroxyurea in the management of sickle cell disease: pharmacogenomics and enzymatic metabolism
Published in The pharmacogenomics journal (01-12-2018)“…Hydroxyurea (HU) was approved to be used in the treatment of sickle cell disease (SCD) because of its anti-sickling potential. However, there is variability in…”
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Circulating MicroRNAs as Novel Potential Diagnostic Biomarkers for Osteosarcoma: A Systematic Review
Published in Biomolecules (Basel, Switzerland) (30-09-2021)“…Osteosarcoma (OS) is a fast-progressing bone tumor with high incidence in children and adolescents. The main diagnostic methods for OS are imaging exams and…”
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Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients
Published in Blood cells, molecules, & diseases (01-09-2018)Get full text
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Hydroxyurea alters circulating monocyte subsets and dampens its inflammatory potential in sickle cell anemia patients
Published in Scientific reports (15-10-2019)“…Sickle cell anemia (SCA) is a hemolytic disease in which vaso-occlusion is an important pathophysiological mechanism. The treatment is based on hydroxyurea…”
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Association of the clinical profile and overall survival of pediatric patients with acute lymphoblastic leukemia
Published in Frontiers in pediatrics (07-09-2023)“…IntroductionThe clarification of etiopathology, the improvement of chemotherapy regimens and their risk stratifications, and the improvement in treatment…”
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Associations between TGF-β1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients
Published in Mediators of inflammation (01-01-2021)“…Transforming growth factor beta (TGF-β) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease…”
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Effect of lysed and non-lysed sickle red cells on the activation of NLRP3 inflammasome and LTB4 production by mononuclear cells
Published in Inflammation research (01-07-2021)“…Objective and design This study tested the hypothesis that sickle red blood cell (SS-RBC) can induce inflammasome NLRP3 components gene expression in…”
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TGFBR3 Polymorphisms (rs1805110 and rs7526590) Are Associated with Laboratory Biomarkers and Clinical Manifestations in Sickle Cell Anemia
Published in Disease markers (2020)“…Individuals with sickle cell anemia (SCA) present chronic anemia, hemolysis, an exacerbated inflammatory response, and heterogeneous clinical complications,…”
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Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters
Published in Disease markers (01-01-2018)“…This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under…”
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Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations
Published in Mediators of inflammation (2020)“…Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response,…”
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Associations between TGF- β 1 Levels and Markers of Hemolysis, Inflammation, and Tissue Remodeling in Pediatric Sickle Cell Patients
Published in Mediators of inflammation (2021)“…Transforming growth factor beta (TGF- ) is a cytokine with important involvement in biological processes related to the pathogenesis of sickle cell disease…”
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A Description of the Hemolytic Component in Sickle Leg Ulcer: The Role of Circulating miR-199a-5p, miR-144, and miR-126
Published in Biomolecules (Basel, Switzerland) (17-02-2022)“…Sickle leg ulcers (SLU) are malleoli lesions with exuberant hemolytic pathophysiology. The microRNAs are potential genetic biomarkers for several pathologies…”
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Association of laboratory markers and cerebral blood flow among sickle cell anemia children
Published in Frontiers in pediatrics (26-08-2022)“…BackgroundStroke is one of the highest complications of sickle-cell anemia (SCA). The Transcranial Doppler (TCD) has been adopted worldwide as a gold standard…”
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Investigation of Lipid Profile and Clinical Manifestations in SCA Children
Published in Disease markers (2020)“…Introduction. Clinical complications in sickle cell anemia (SCA) are heterogeneous and involve several molecules. It has been suggested that SCA individuals…”
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Laboratory and Genetic Biomarkers Associated with Cerebral Blood Flow Velocity in Hemoglobin SC Disease
Published in Disease markers (01-01-2017)“…Reference values for cerebral blood flow velocity (CBFV) in hemoglobin SC disease (HbSC) have not been established. We aimed to investigate associations…”
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Association of classical markers and establishment of the dyslipidemic sub-phenotype of sickle cell anemia
Published in Lipids in health and disease (11-04-2017)“…Sickle cell anemia (SCA) patients exhibit sub-phenotypes associated to hemolysis and vaso-occlusion. The disease has a chronic inflammatory nature that has…”
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Genetic modulation of fetal hemoglobin in hydroxyurea‐treated sickle cell anemia
Published in American journal of hematology (01-05-2017)Get full text
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Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia
Published in Expert review of hematology (03-06-2017)“…Hemolysis triggers the onset of several clinical manifestations of sickle cell anemia (SCA). During hemolysis, heme, which is derived from hemoglobin (Hb),…”
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