Search Results - "Alekshun, Michael N"

Molecular Mechanisms of Antibacterial Multidrug Resistance by Alekshun, Michael N., Levy, Stuart B.

“…Treatment of infections is compromised worldwide by the emergence of bacteria that are resistant to multiple antibiotics. Although classically attributed to…”
Get full text

The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 Å resolution by Head, James F, Alekshun, Michael N, Levy, Stuart B, Mealy, Tanya R, Seaton, Barbara A

“…MarR is a regulator of multiple antibiotic resistance in Escherichia coli. It is the prototypical member of the MarR family of regulatory proteins found in…”
Get full text

Small Molecule Inhibitors of LcrF, a Yersinia pseudotuberculosis Transcription Factor, Attenuate Virulence and Limit Infection in a Murine Pneumonia Model by Garrity-Ryan, Lynne K, Kim, Oak K, Balada-Llasat, Joan-Miquel, Bartlett, Victoria J, Verma, Atul K, Fisher, Michael L, Castillo, Cynthia, Songsungthong, Warangkhana, Tanaka, S. Ken, Levy, Stuart B, Mecsas, Joan, Alekshun, Michael N

“…LcrF (VirF), a transcription factor in the multiple adaptational response (MAR) family, regulates expression of the Yersinia type III secretion system (T3SS)…”
Get full text

The mar regulon: multiple resistance to antibiotics and other toxic chemicals by Alekshun, Michael N, Levy, Stuart B

“…The chromosomal multiple antibiotic resistance ( mar) locus of Escherichia coli and other members of the Enterobacteriaceae controls resistance to multiple,…”
Get full text

N-Hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF in Yersinia: Novel Antivirulence Agents by Kim, Oak K., Garrity-Ryan, Lynne K., Bartlett, Victoria J., Grier, Mark C., Verma, Atul K., Medjanis, Gabriel, Donatelli, Janice E., Macone, Ann B., Tanaka, S. Ken, Levy, Stuart B., Alekshun, Michael N.

“…LcrF, a multiple adaptational response (MAR) transcription factor, regulates virulence in Yersinia pestis and Yersinia pseudotuberculosis. In a search for…”
Get full text

New advances in antibiotic development and discovery by Alekshun, Michael N

“…The development of new antibiotics is crucial to controlling current and future infectious diseases caused by antibiotic-resistant bacteria. Increased…”
Get more information

Novel anti-infection agents: Small-molecule inhibitors of bacterial transcription factors by Bowser, Todd E., Bartlett, Victoria J., Grier, Mark C., Verma, Atul K., Warchol, Taduesz, Levy, Stuart B., Alekshun, Michael N.

“…Inhibitors of AraC bacterial transcription factors are shown to limit infections by reducing virulence rather than halting growth of the organisms. This…”
Get full text

N-Hydroxybenzimidazole inhibitors of ExsA MAR transcription factor in Pseudomonas aeruginosa: In vitro anti-virulence activity and metabolic stability by Grier, Mark C., Garrity-Ryan, Lynne K., Bartlett, Victoria J., Klausner, Kevin A., Donovan, Peter J., Dudley, Caroline, Alekshun, Michael N., Ken Tanaka, S., Draper, Michael P., Levy, Stuart B., Kim, Oak K.

“…Inhibitors for ExsA-DNA binding in Pseudomonas aeruginosa. ExsA is a multiple adaptational response (MAR) transcription factor, regulating the expression of a…”
Get full text

Alteration of the Repressor Activity of MarR, the Negative Regulator of the Escherichia coli marRAB Locus, by Multiple Chemicals In Vitro by Alekshun, M N, Levy, S B

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

44th Interscience Conference on Antimicrobial Agents and Chemotherapy: an update on new antibiotics, novel non-antibacterial treatment modalities and critical issues in antibiotic resistance by Alekshun, Michael N

“…The recent 44th annual Interscience Conference on Antimicrobial Agents and Chemotherapy provided a snapshot of the antibiotics most advanced in clinical…”
Get more information

Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA binding by Alekshun, Michael N., Kim, Yang Soo, Levy, Stuart B.

“…MarR, the negative regulator of the Escherichia coli multiple antibiotic resistance (marRAB) operon, is a member of a newly recognized family of regulatory…”
Get full text

Characterization of MarR Superrepressor Mutants by Alekshun, M N, Levy, S B

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Multidrug Resistance following Expression of the Escherichia coli marA Gene in Mycobacterium smegmatis by McDermott, P F, White, D G, Podglajen, I, Alekshun, M N, Levy, S B

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis by Casaz, Paul, Garrity-Ryan, Lynne K, McKenney, David, Jackson, Caroline, Levy, Stuart B, Tanaka, S. Ken, Alekshun, Michael N

“…1 Paratek Pharmaceuticals, Inc., 75 Kneeland Street, Boston, MA 02111, USA 2 Center for Adaptation Genetics and Drug Resistance, Tufts University School of…”
Get full text

Beyond comparison-antibiotics from genome data? by Alekshun, Michael N

“…Antibiotics need more variety. Most current compounds are mere analogs of earlier antibiotic classes, targeting a paltry number of bacterial targets. Several…”
Get full text

Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon by ALEKSHUN, M. N, LEVY, S. B

“…Descriptions of intrinsic mechanisms that confer multidrug resistance have begun to emerge. The first of these was a chromosomally encoded multiple antibiotic…”
Get full text

N-hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF in Yersinia: Novel Anti-Virulence Agents by Kim, Oak K., Garrity-Ryan, Lynne K., Bartlett, Victoria J., Grier, Mark C., Verma, Atul K., Medjanis, Gabriel, Donatelli, Janice E., Macone, Ann B., Tanaka, S. Ken, Levy, Stuart B., Alekshun, Michael N.

“…LcrF, a Multiple Adaptational Response (MAR) transcription factor, regulates virulence in Yersinia pestis and Yersinia pseudotuberculosis . In a search for…”
Get full text