Search Results - "Aleksandrova, Yu R"

Conjugates of 3,5-Bis(arylidene)-4-piperidone and Sesquiterpene Lactones Have an Antitumor Effect via Resetting the Metabolic Phenotype of Cancer Cells by Neganova, M E, Aleksandrova, Yu R, Sharova, E V, Smirnova, E V, Artyushin, O I, Nikolaeva, N S, Semakov, A V, Schagina, I A, Akylbekov, N, Kurmanbayev, R, Orynbekov, D, Brel, V K

“…In recent years, researchers have often encountered the significance of the aberrant metabolism of tumor cells in the pathogenesis of malignant neoplasms. This…”
Get full text

Synthesis and antitumor activity of new pinane C,N-palladacycles containing l-amino acids as coligands by Gur’eva, Ya. A., Zalevskaya, O. A., Nikolaeva, N. S., Aleksandrova, Yu. R., Yandulova, E. Yu, Neganova, M. E., Kutchin, A. V.

“…Four new palladium complexes containing a cyclometallated pinane ligand and l -amino acids (proline, tyrosine, serine, isoleucine) as coligands were…”
Get full text

Chiral zinc complexes with terpene derivatives of ethylenediamine: synthesis and biological activity by Gur’eva, Y. A., Zalevskaya, O. A., Nikolaeva, N. S., Aleksandrova, Yu. R., Yandulova, E. Yu, Neganova, M. E., Slepukhin, P. A., Kutchin, A. V.

“…Six new chiral zinc( ii ) complexes 1–6 based on ethylenediamine derivatives of terpenes were synthesized and characterized. The molecular structure of complex…”
Get full text

Modification of Sesquiterpene Lactones—Dehydrocostus Lactone and Alantolactone—by Click Chemistry Method. Cytotoxic Activity of the Obtained Conjugates by Artyushin, O. I., Sharova, E. V., Nikolaeva, N. S., Aleksandrova, Yu. R., Semakov, A. V., Neganova, M. E., Brel, V. K.

“…A method for modifying sesquiterpene lactones using the click chemistry methodology has been developed. A series of conjugates of alantolactone and…”
Get full text

Tryptamine Derivatives of Sesquiterpene Lactones as Effective β-Secretase 1 Inhibitors by Aleksandrova, Yu. R., Semakov, A. V., Vinyukova, E. Yu, Afanasyeva, S. V., Pukhov, S. A., Balakin, K. V., Neganova, M. E.

“…Modification of eudesmane-type sesquiterpene lactones and their epoxy derivatives with tryptamines was carried out using the aza-Michael reaction. A series of…”
Get full text

New Arteannuin B Derivatives and Their Cytotoxic Activity by Klochkov, S. G., Neganova, M. E., Pukhov, S. A., Afanas’eva, S. V., Aleksandrova, Yu. R., Yandulova, E. Yu

“…Previously unknown conjugates of the natural sesquiterpene lactone arteannuin B, which was isolated from Artemisia annua , were synthesized via Michael…”
Get full text

The Role of a Pathological Interaction between β-amyloid and Mitochondria in the Occurrence and Development of Alzheimer's Disease by Nikolaeva, N S, Yandulova, E Yu, Aleksandrova, Yu R, Starikov, A S, Neganova, M E

“…Alzheimer's disease (AD) is one of the most common neurodegenerative diseases in existence. It is characterized by an impaired cognitive function that is due…”
Get full text

Mechanisms of the Cytotoxic Action of Novel Cyclic Hydroxamic Acids by Neganova, M. E., Aleksandrova, Yu. R., Pukhov, S. A., Klochkov, S. G., Osipov, V. N.

“…— Cyclic hydroxamic acids (CHAs) based on quinazoline-4(3H)-one and dihydroquinazoline-4(1H)-one have been synthesized. The antioxidant and iron-chelating…”
Get full text

Regioselective Synthesis, Structure, and Chemosensitizing Antitumor Activity of Cyclic Hydroxamic Acid Based on DL-Valine by Vystorop, I. V., Shilov, G. V., Chernyak, A. V., Klimanova, E. N., Sashenkova, T. E., Klochkov, S. G., Neganova, M. E., Aleksandrova, Yu. R., Allayarova, U. Yu, Mishchenko, D. V.

“…— The reaction of DL-valine hydroxamic acid with triacetonamine proceeds as the N , N '-regioselective condensation to form…”
Get full text

Promising Molecular Targets for Pharmacological Therapy of Neurodegenerative Pathologies by Neganova, M E, Aleksandrova, Yu R, Nebogatikov, V O, Klochkov, S G, Ustyugov, A A

“…Drug development for the treatment of neurodegenerative diseases has to confront numerous problems occurring, in particular, because of attempts to address…”
Get full text

Promising Molecular Targets for Design of Antitumor Drugs Based on Ras Protein Signaling Cascades by Klochkov, S. G., Neganova, M. E., Aleksandrova, Yu. R.

“…Oncological diseases have always been among the most significant pathologies. Therefore, development of effective antitumor drugs is considered one of the…”
Get full text

Palladium complexes with terpene derivatives of ethylenediamine and benzylamine: Synthesis and study of antitumor properties by Zalevskaya, O.A., Gur'eva, Y.A., Kutchin, A.V., Aleksandrova, Yu.R., Yandulova, E.Yu, Nikolaeva, N.S., Neganova, M.E.

“…[Display omitted] •The synthesis of new terpene ligands and palladium complexes is presented.•The study of the toxic effect was carried out on various cell…”
Get full text