Search Results - "Alejaldre, Lorea"

Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot by Quaglia, Daniela, Alejaldre, Lorea, Ouadhi, Sara, Rousseau, Olivier, Pelletier, Joelle N

“…Through the application of a region-focused saturation mutagenesis and randomization approach, protein engineering of the Cal-A enzyme was undertaken with the…”
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Insights into Laccase Engineering from Molecular Simulations: Toward a Binding-Focused Strategy by Monza, Emanuele, Lucas, M. Fatima, Camarero, Susana, Alejaldre, Lorea C, Martínez, Angel T, Guallar, Victor

“…Understanding the molecular determinants of enzyme performance is of primary importance for the rational design of ad hoc mutants. A novel approach, which…”
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Known Evolutionary Paths Are Accessible to Engineered ß-Lactamases Having Altered Protein Motions at the Timescale of Catalytic Turnover by Alejaldre, Lorea, Lemay-St-Denis, Claudèle, Perez Lopez, Carles, Sancho Jodar, Ferran, Guallar, Victor, Pelletier, Joelle N

“…The evolution of new protein functions is dependent upon inherent biophysical features of proteins. Whereas, it has been shown that changes in protein dynamics…”
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Methods for enzyme library creation: Which one will you choose?: A guide for novices and experts to introduce genetic diversity by Alejaldre, Lorea, Pelletier, Joelle N, Quaglia, Daniela

“…Enzyme engineering allows to explore sequence diversity in search for new properties. The scientific literature is populated with methods to create enzyme…”
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Methods for enzyme library creation: Which one will you choose? by Alejaldre, Lorea, Pelletier, Joelle N., Quaglia, Daniela

“…Enzyme engineering allows to explore sequence diversity in search for new properties. The scientific literature is populated with methods to create enzyme…”
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Tuning Selectivity in CalA Lipase: Beyond Tunnel Engineering by Alejaldre, Lorea, Lemay-St-Denis, Claudèle, Pelletier, Joelle N., Quaglia, Daniela

“…Engineering studies of Candida (Pseudozyma) antarctica lipase A (CalA) have demonstrated the potential of this enzyme in the selective hydrolysis of fatty acid…”
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SEVA 4.0: an update of the Standard European Vector Architecture database for advanced analysis and programming of bacterial phenotypes by Martínez-García, Esteban, Fraile, Sofía, Algar, Elena, Aparicio, Tomás, Velázquez, Elena, Calles, Belén, Tas, Huseyin, Blázquez, Blas, Martín, Bruno, Prieto, Clara, Sánchez-Sampedro, Lucas, Nørholm, Morten H H, Volke, Daniel C, Wirth, Nicolas T, Dvořák, Pavel, Alejaldre, Lorea, Grozinger, Lewis, Crowther, Matthew, Goñi-Moreno, Angel, Nikel, Pablo I, Nogales, Juan, de Lorenzo, Víctor

“…The SEVA platform (https://seva-plasmids.com) was launched one decade ago, both as a database (DB) and as a physical repository of plasmid vectors for genetic…”
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The Laboratory Automation Protocol (LAP) Format and Repository: A Platform for Enhancing Workflow Efficiency in Synthetic Biology by Anhel, Ana-Mariya, Alejaldre, Lorea, Goñi-Moreno, Ángel

“…Laboratory automation deals with eliminating manual tasks in high-throughput protocols. It therefore plays a crucial role in allowing fast and reliable…”
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A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype by Lemay-St-Denis, Claudèle, Alejaldre, Lorea, Jemouai, Zakaria, Lafontaine, Kiana, St-Aubin, Maxime, Hitache, Katia, Valikhani, Donya, Weerasinghe, Nuwani W, Létourneau, Myriam, Thibodeaux, Christopher J, Doucet, Nicolas, Baron, Christian, Copp, Janine N, Pelletier, Joelle N

“…We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B…”
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Integron-Associated DfrB4, a Previously Uncharacterized Member of the Trimethoprim-Resistant Dihydrofolate Reductase B Family, Is a Clinically Identified Emergent Source of Antibiotic Resistance by Toulouse, Jacynthe L, Edens, Thaddeus J, Alejaldre, Lorea, Manges, Amee R, Pelletier, Joelle N

“…Whole-genome sequencing of trimethoprim-resistant clinical isolates identified a member of the trimethoprim-resistant type II dihydrofolate reductase gene…”
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pBLAM1-x: standardized transposon tools for high-throughput screening by Alejaldre, Lorea, Anhel, Ana-Mariya, Goñi-Moreno, Ángel

“…Abstract The engineering of pre-defined functions in living cells requires increasingly accurate tools as synthetic biology efforts become more ambitious…”
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Development of sulfahydantoin derivatives as β-lactamase inhibitors by Paquet-Côté, Pierre-Alexandre, Alejaldre, Lorea, Lapointe Verreault, Camille, Gobeil, Sophie M.C., Lamoureux, Rosalie, Bédard, Laurie, Normandeau, Charles-Olivier, Lemay-St-Denis, Claudèle, Pelletier, Joelle N., Voyer, Normand

“…[Display omitted] Sulfahydantoin-based molecules may provide a means to counteract antibiotic resistance, which is on the rise. These molecules may act as…”
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G-Equivalent Acceleration Tolerance in the Eutardigrade Species Hypsibius dujardini by Vasanthan, Tarushika, Alejaldre, Lorea, Hider, Jessica, Patel, Shreya, Husain, Nabiha, Umapathisivam, Bavithra, Stone, Jonathon

“…Tardigrades are microscopic organisms renowned for their ability to survive extreme environmental conditions. Tardigrade extreme-tolerance research has…”
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Insights on Laccase Engineering from Molecular Simulations: Towards a Binding Focused Strategy by Monza, Emanuele, Lucas, Fatima, Camarero, Susana, Alejaldre, Lorea C, Martínez, Angel T, Guallar, Víctor

“…Understanding the molecular determinants of enzyme performance is of primary importance for the rational design of ad hoc mutants. A novel approach, which…”
Get full text