Search Results - "Alegre, L M"

Delayed Cytotoxic T Lymphocyte–Associated Protein 4–Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection by Young, J. S., Chen, J., Miller, M. L., Vu, V., Tian, C., Moon, J. J., Alegre, M.‐L., Sciammas, R., Chong, A. S.

“…Antibody‐mediated rejection has emerged as the leading cause of late graft loss in kidney transplant recipients, and inhibition of donor‐specific antibody…”
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The Microbiota, the Immune System and the Allograft by Alegre, M.‐L., Mannon, R. B., Mannon, P. J.

“…The microbiota represents the complex collections of microbial communities that colonize a host. In health, the microbiota is essential for metabolism,…”
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Erosion of Transplantation Tolerance After Infection by Young, J. S., Daniels, M. D., Miller, M. L., Wang, T., Zhong, R., Yin, D., Alegre, M.‐L., Chong, A. S.

“…Recent clinical studies suggest that operational allograft tolerance can be persistent, but long‐term surviving allografts can be rejected in a subset of…”
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TLR Engagement Prevents Transplantation Tolerance by Chen, L., Wang, T., Zhou, P., Ma, L., Yin, D., Shen, J., Molinero, L., Nozaki, T., Phillips, T., Uematsu, S., Akira, S., Wang, C.‐R., Fairchild, R. L., Alegre, M.‐L., Chong, A.

“…In many experimental models, heart, pancreas and kidney allografts are accepted long‐term following costimulation‐targeting therapies, whereas skin, lung and…”
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IL‐6 Induced by Staphylococcus aureus Infection Prevents the Induction of Skin Allograft Acceptance in Mice by Ahmed, E. B., Wang, T., Daniels, M., Alegre, M‐L., Chong, A. S.

“…Clinical correlations between bacterial infections and rejection suggest a hypothesis that innate immune stimulation by bacterial infections results in the…”
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Tracking of TCR‐Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice by Miller, M. L., Daniels, M. D., Wang, T., Wang, Y., Xu, J., Yin, D., Chong, A. S., Alegre, M.‐L.

“…Solid organ transplantation tolerance can be achieved following select transient immunosuppressive regimens that result in long‐lasting restraint of…”
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IFN‐γ: The Dr. Jekyll and Mr. Hyde of Immunology? by Evaristo, C., Alegre, M.‐L.

“…Interferon‐gamma affects alloresponses following corneal transplantation in opposite ways depending on donor/recipient combinations, suggesting that a closer…”
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Role of Natural Killer Cell Subsets in Cardiac Allograft Rejection by McNerney, M. E., Lee, K.‐M., Zhou, P., Molinero, L., Mashayekhi, M., Guzior, D., Sattar, H., Kuppireddi, S., Wang, C.‐R., Kumar, V., Alegre, M.‐L.

“…To achieve donor‐specific immune tolerance to allogeneic organ transplants, it is imperative to understand the cell types involved in acute allograft…”
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Infection with the Intracellular Bacterium, Listeria monocytogenes, Overrides Established Tolerance in a Mouse Cardiac Allograft Model by Wang, T., Ahmed, E. B., Chen, L., Xu, J., Tao, J., Wang, C.‐R., Alegre, M.‐L., Chong, A. S.

“…Infections and TLR signals at the time of transplantation have been shown to prevent the induction of tolerance, but their effect on allografts after tolerance…”
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Adoptive Transfer of Tracer‐Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft by Miller, M. L., Chen, J., Daniels, M. D., McKeague, M. G., Wang, Y., Yin, D., Vu, V., Chong, A. S., Alegre, M.‐L.

“…T cell receptor transgenic (TCR‐Tg) T cells are often used as tracer populations of antigen‐specific responses to extrapolate findings to endogenous T cells…”
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Effects of resistance training with moderate vs heavy loads on muscle mass and strength in the elderly: A meta-analysis by Csapo, R., Alegre, L. M.

“…The purpose of the present study was to perform a meta‐analysis to compare the efficacy of heavy (∼80% of one repetition maximum, 1RM) vs light‐moderate load…”
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Mechanisms of CTLA-4-Ig in tolerance induction by Alegre, M-L, Fallarino, F

“…The size of the peripheral T lymphocyte pool remains relatively constant throughout adult life, but individual populations undergo expansion and contraction…”
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CTLA-4 Gene Polymorphism at Position 49 in Exon 1 Reduces the Inhibitory Function of CTLA-4 and Contributes to the Pathogenesis of Graves' Disease by Kouki, Tsuyoshi, Sawai, Yoshikuni, Gardine, Cyprian A, Fisfalen, Maria-Elena, Alegre, Maria-Luisa, DeGroot, Leslie J

“…Activation of T cells requires at least two signals transduced by the Ag-specific TCR and a costimulatory ligand such as CD28. CTLA-4, expressed on activated T…”
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T-cell regulation by CD28 and CTLA-4 by Alegre, Maria-Luisa, Frauwirth, Kenneth A, Thompson, Craig B

“…Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one…”
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The Inside Story of Dendritic Cell Immunotherapy by Alegre, M.‐L., Molinero, L. L.

“…The authors discuss the paper by Wang et al (page 1398) demonstrating that the immunosuppressive effect of systemically injected donor or alloantigen‐loaded…”
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“Tip‐Toeing” to an Assay for Transplantation Tolerance? by Alegre, M.‐L., Chong, A. S.

“…The authors provide a perspective on the article by Haynes and colleagues (page 640) who find that the degree linked‐suppression, as measured by the trans‐vivo…”
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Donor Lymphoid Organs Are a Major Site of Alloreactive T‐Cell Priming Following Intestinal Transplantation by Wang, J., Dong, Y., Sun, J.‐Z., Taylor, R. T., Guo, C., Alegre, M.‐L., Williams, I. R., Newell, K. A.

“…We hypothesized that lymphoid organs within intestinal allografts contribute to their immunogenicity. Consistent with this hypothesis recipient T cells rapidly…”
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Evolution and trends in a pediatric cardiac magnetic resonance imaging program in a tertiary hospital over a 14-year period by Marín Rodríguez, C, Álvarez Martín, T, Lancharro Zapata, Á, Ruiz Martín, Y, Sánchez Alegre, M L, Delgado Carrasco, J

“…1. To review the activity in our hospital's pediatric cardiac magnetic resonance imaging (cMRI) program from its inception to the present. 2. To evaluate…”
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Changes in footprint with resistance exercise by Jimenez-Ormeño, E, Aguado, X, Delgado-Abellan, L, Mecerreyes, L, Alegre, L M

“…We aimed to describe the changes in footprint characteristics after 2 types of resistance training sessions performed at different intensities. 18 young…”
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Epidermal Langerhans Cells Promote Skin Allograft Rejection in Mice With NF‐κB‐impaired T Cells by Molinero, L. L., Zhou, P., Wang, Y., Harlin, H., Kee, B., Abraham, C., Alegre, M. L.

“…T cells play a major role in the acute rejection of transplanted organs. Using mice transgenic for a T‐cell‐restricted NF‐κB super‐repressor (IκBαΔN‐Tg mice),…”
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