Search Results - "Alegre, Javier"

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders by Agarwal, Devika, Sandor, Cynthia, Volpato, Viola, Caffrey, Tara M., Monzón-Sandoval, Jimena, Bowden, Rory, Alegre-Abarrategui, Javier, Wade-Martins, Richard, Webber, Caleb

“…We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN), generated by sequencing approximately 17,000 nuclei from matched cortical…”
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Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells by Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard

“…ABSTRACT Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To…”
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Giant cell arteritis presenting with unilateral sixth nerve palsy by Colquhoun, Matthew, Alegre Abarrategui, Javier, Shahzad, Muhammad Ibrahim, Ellis, Benjamin

“…Giant cell arteritis (GCA) usually presents with headache, scalp tenderness and raised inflammatory markers. GCA presenting with a clinically evident cranial…”
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Multisystem screening reveals SARS‐CoV‐2 in neurons of the myenteric plexus and in megakaryocytes by Gray‐Rodriguez, Sandra, Jensen, Melanie P, Otero‐Jimenez, Maria, Hanley, Brian, Swann, Olivia C, Ward, Patrick A, Salguero, Francisco J, Querido, Nadira, Farkas, Ildiko, Velentza‐Almpani, Elisavet, Weir, Justin, Barclay, Wendy S, Carroll, Miles W, Jaunmuktane, Zane, Brandner, Sebastian, Pohl, Ute, Allinson, Kieren, Thom, Maria, Troakes, Claire, Al‐Sarraj, Safa, Sastre, Magdalena, Gveric, Djordje, Gentleman, Steve, Roufosse, Candice, Osborn, Michael, Alegre‐Abarrategui, Javier

“…SARS‐CoV‐2, the causative agent of COVID‐19, typically manifests as a respiratory illness, although extrapulmonary involvement, such as in the gastrointestinal…”
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Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson's disease brain by Roberts, Rosalind F, Wade-Martins, Richard, Alegre-Abarrategui, Javier

“…Oligomeric forms of alpha-synuclein are emerging as key mediators of pathogenesis in Parkinson's disease. Our understanding of the exact contribution of…”
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Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum by Alegre-Cortés, Javier, Sáez, María, Montanari, Roberto, Reig, Ramon

“…Behavioral studies differentiate the rodent dorsal striatum (DS) into lateral and medial regions; however, anatomical evidence suggests that it is a unified…”
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A New Micro-holder Device for Local Drug Delivery during In Vivo Whole-cell Recordings by Sáez, María, Ketzef, Maya, Alegre-Cortés, Javier, Reig, Ramón, Silberberg, Gilad

“…•Versatile and cheap device for precise and stable drug application for in vivo intracellular recordings in deep brain areas.•BMI modifies the properties of…”
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Feasible Use of Recycled Concrete Aggregates with Alumina Waste in Road Construction by Cabrera, Manuel, López-Alonso, Mónica, Garach, Laura, Alegre, Javier, Ordoñez, Javier, Agrela, Francisco

“…The management of different industrial by-products, such as recycled aggregates from construction and demolition waste and alumina by-products, as well as the…”
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Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction by Gordon, David, Dafinca, Ruxandra, Scaber, Jakub, Alegre-Abarrategui, Javier, Farrimond, Lucy, Scott, Connor, Biggs, Daniel, Kent, Louisa, Oliver, Peter L., Davies, Benjamin, Ansorge, Olaf, Wade-Martins, Richard, Talbot, Kevin

“…Mutations in the gene encoding the RNA-binding protein TDP-43 cause amyotrophic lateral sclerosis (ALS), clinically and pathologically indistinguishable from…”
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Beyond Strains: Molecular Diversity in Alpha-Synuclein at the Center of Disease Heterogeneity by Wojewska, Marcelina J, Otero-Jimenez, Maria, Guijarro-Nuez, Jose, Alegre-Abarrategui, Javier

“…Alpha-synucleinopathies (α-synucleinopathies) such as Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), dementia with Lewy bodies (DLB), and…”
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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model by Alegre-Abarrategui, Javier, Christian, Helen, Lufino, Michele M.P., Mutihac, Ruxandra, Venda, Lara Lourenço, Ansorge, Olaf, Wade-Martins, Richard

“…Leucine rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD) although LRRK2 function remains unclear. We report…”
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Improvement of Bearing Capacity in Recycled Aggregates Suitable for Use as Unbound Road Sub-Base by Garach, Laura, López, Mónica, Agrela, Francisco, Ordóñez, Javier, Alegre, Javier, Moya, José Antonio

“…Recycled concrete aggregates and mixed recycled aggregates are specified as types of aggregates with lower densities, higher water absorption capacities, and…”
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Autofluorescent Cancer Stem Cells: Potential Biomarker to Predict Recurrence in Resected Colorectal Tumors by Alcala, Sonia, Serralta San Martin, Gonzalo, Muñoz-Fernández de Legaria, Marta, Moreno-Rubio, Juan, Salinas, Silvia, López-Gil, Juan Carlos, Rojo López, José Alberto, Martínez Alegre, Javier, Cortes Bandy, David Abraham, Zambrana, Francisco, Jiménez-Gordo, Ana-María, Casado, Enrique, López-Gómez, Miriam, Sainz, Bruno

“…Cancer stem cells (CSC) in colorectal cancer drive intratumoral heterogeneity and distant metastases. Previous research from our group showed that CSCs can be…”
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A COMPUTATIONAL MODEL OF SLOW WAVE OSCILLATION PROPAGATION ACROSS CORTICAL AND STRIATAL NETWORKS by Alegre-Cortés, Javier, Mattia, Maurizio, Reig, Ramon

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Desigualdad y trabajo: un camino a revertir by Alegre, Javier

“…El presente artículo aborda el notable crecimiento de las desigualdades socio-económicas a escala global, dado en las últimas décadas a partir de la imposición…”
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A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells by Phadwal, Kanchan, Alegre-Abarrategui, Javier, Watson, Alexander Scarth, Pike, Luke, Anbalagan, Selvakumar, Hammond, Ester M., Wade-Martins, Richard, McMichael, Andrew, Klenerman, Paul, Simon, Anna Katharina

“…Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in…”
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Toward an Improvement of the Analysis of Neural Coding by Alegre-Cortés, Javier, Soto-Sánchez, Cristina, Albarracín, Ana L, Farfán, Fernando D, Val-Calvo, Mikel, Ferrandez, José M, Fernandez, Eduardo

“…Machine learning and artificial intelligence have strong roots on principles of neural computation. Some examples are the structure of the first perceptron,…”
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THE ROLE OF THE CALLOSAL CONNECTIONS MEDIATING THE INTERHEMISPHERIC COMMUNICATION OF THE BARREL CORTEX by Alonso-Andrés, Alicia, Montanari, Roberto, Alegre-Cortés, Javier, Reig, Ramon

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Impairment of Macroautophagy in Dopamine Neurons Has Opposing Effects on Parkinsonian Pathology and Behavior by Hunn, Benjamin H.M., Vingill, Siv, Threlfell, Sarah, Alegre-Abarrategui, Javier, Magdelyns, Morgane, Deltheil, Thierry, Bengoa-Vergniory, Nora, Oliver, Peter L., Cioroch, Milena, Doig, Natalie M., Bannerman, David M., Cragg, Stephanie J., Wade-Martins, Richard

“…Parkinson’s disease (PD) is characterized by the death of dopamine neurons in the substantia nigra pars compacta (SNc) and accumulation of α-synuclein…”
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Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease by Bengoa-Vergniory, Nora, Velentza-Almpani, Elisavet, Silva, Ana Maria, Scott, Connor, Vargas-Caballero, Mariana, Sastre, Magdalena, Wade-Martins, Richard, Alegre-Abarrategui, Javier

“…Multimerization is a key process in prion-like disorders such as Alzheimer's disease (AD), since it is a requirement for self-templating tau and beta-amyloid…”
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