Estrogen replacement and exercise capacity in postmenopausal women: A randomized placebo-controlled study

Objective. We tested the hypothesis that estrogen replacement (2 mg estradiol day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women. Study design. Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 ± 2...

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Bibliographic Details
Published in:	Gynecological endocrinology Vol. 21; no. 6; pp. 324 - 329
Main Authors:	Aldrighi, José M., Calvoso-Júnior, Roberto, Alecrin, Israel N., Trombetta, Ivani C., Negrão, Carlos E.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01-12-2005 Taylor & Francis Taylor & Francis Ltd
Subjects:	Estradiol - pharmacology Estrogen Replacement Therapy Exercise Test Exercise Tolerance - drug effects Female functional capacity Gonadal Steroid Hormones - pharmacology Humans Middle Aged Postmenopausal Postmenopause - drug effects
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Summary:	Objective. We tested the hypothesis that estrogen replacement (2 mg estradiol day, orally for 90 days) would improve cardiopulmonary and functional capacities in postmenopausal women. Study design. Twenty-three postmenopausal and sedentary women were divided into estrogen replacement (n = 13, 57 ± 2 years) and placebo control (n = 10, 58 ± 2 years) groups. They performed a cardiopulmonary exercise test before and after the intervention. Results. Baseline measurements were similar between groups. Blood pressure and heart rate at rest and during exercise were unchanged by estrogen treatment, and estrogen did not alter pulmonary measurements at rest and during exercise. Oxygen consumption at anaerobic threshold, respiratory compensation point and peak exercise were lower after estrogen replacement, despite the unchanged workload and exercise time to exhaustion. In the placebo control group, no change in peak oxygen consumption, workload and time to exhaustion was found. Conclusions. Estrogen does not change cardiopulmonary responses to submaximal and maximal exercise in postmenopausal women. In addition, estrogen fails to improve exercise capacity in postmenopausal women.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23
ISSN:	0951-3590 1473-0766
DOI:	10.1080/09513590500430831