Pattern of ovarian progesterone secretion during the luteal phase of the ovine estrous cycle

Pulsatile secretion of progesterone has been observed during the late luteal phase of the menstrual cycle in the rhesus monkey and human. As the luteal phase progresses in each of these species, there is a pattern of decreased frequency and increased amplitude of progesterone pulses. The present stu...

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Bibliographic Details
Published in:	Biology of reproduction Vol. 39; no. 2; pp. 287 - 294
Main Authors:	Alecozay, A.A, Selcer, K.W, Clark, J.R, Burns, J.M, Norman, R.L, Niswender, G.D, Leavitt, W.W
Format:	Journal Article
Language:	English
Published:	Madison, WI Society for the Study of Reproduction 01-09-1988
Subjects:	Animals Biological and medical sciences Biological Assay BREBIS CICLO ESTRAL CYCLE OESTRAL Estrus - metabolism EWES Female Fundamental and applied biological sciences. Psychology HORMONAS HORMONE HORMONES Luteal Phase Luteinizing Hormone - analysis Mammalian female genital system Morphology. Physiology OESTROUS CYCLE Ovary - metabolism OVEJA PROGESTERONA PROGESTERONE Progesterone - analysis Progesterone - metabolism Radioimmunoassay SECRECION SECRETION Sheep - physiology Vertebrates: reproduction Amplitude Ovarian hormone Progestagen Vertebrata Mammalia Postovulation Secretion curve Pulsatile Frequency Sheep Artiodactyla Estrous cycle Progesterone Sex steroid hormone Ungulata
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Summary:	Pulsatile secretion of progesterone has been observed during the late luteal phase of the menstrual cycle in the rhesus monkey and human. As the luteal phase progresses in each of these species, there is a pattern of decreased frequency and increased amplitude of progesterone pulses. The present study was designed to determine the pattern of progesterone secretion during the late luteal phase (Days 10-16) of the normal ovine estrous cycle. Five unanesthetized ewes, each bearing an indwelling cannula in the utero-ovarian vein, were bled every 15 min from 0800 h on Day 10 through 0800 h on Day 16 of the estrous cycle. With the computer program PULSAR, it was determined that progesterone secretion was episodic, with pulsations observed on all days. Analysis of variance was used to determine differences in frequency, amplitude, and interpeak interval (IPI) of progesterone pulses among ewes and days. The ewes averaged 8.0 +/- 0.63 pulses of progesterone per 24 h. Mean frequency of pulses was not different between days but showed differences between ewes. Mean amplitude of progesterone pulses was 7.0 +/- 0.27 ng/ml, with no differences observed either between days or between ewes. Mean IPI was 197 +/- 7.1 min, and, like frequency, the IPI was not different between days, but varied between ewes. No consistent temporal relationship was found between progesterone pulses and luteinizing hormone (LH), as determined by bioassay and radioimmunoassay, on Day 14 of the cycle in one ewe. The results indicate that progesterone secretion is episodic during the luteal phase of the ovine estrous cycle and is independent of LH pulses.
Bibliography:	8904354 L53 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0006-3363 1529-7268
DOI:	10.1095/biolreprod39.2.287