Search Results - "Alečković, Masa"

Regulation of cancer metastasis by cell-free miRNAs by Alečković, Maša, Kang, Yibin

“…MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer…”
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Metastasis as a systemic disease: molecular insights and clinical implications by Alečković, Maša, McAllister, Sandra S., Polyak, Kornelia

“…Metastasis is a complex systemic disease that develops as a result of interactions between tumor cells and their local and distant microenvironments. Local and…”
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Welcoming Treat: Astrocyte-Derived Exosomes Induce PTEN Suppression to Foster Brain Metastasis by Alečković, Maša, Kang, Yibin

“…Metastasis to distant organs depends on pathological crosstalk between tumor cells and various tissue-specific stromal components. Zhang and colleagues…”
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET by Peinado, Héctor, Alečković, Maša, Lavotshkin, Simon, Matei, Irina, Costa-Silva, Bruno, Moreno-Bueno, Gema, Hergueta-Redondo, Marta, Williams, Caitlin, García-Santos, Guillermo, Ghajar, Cyrus M, Nitadori-Hoshino, Ayuko, Hoffman, Caitlin, Badal, Karen, Garcia, Benjamin A, Callahan, Margaret K, Yuan, Jianda, Martins, Vilma R, Skog, Johan, Kaplan, Rosandra N, Brady, Mary S, Wolchok, Jedd D, Chapman, Paul B, Kang, Yibin, Bromberg, Jacqueline, Lyden, David

“…Exosomes can transfer proteins and nucleic acids from one cell to another, altering the phenotype of the recipient cell. In the case of cancer, tumor-derived…”
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Identification of Nidogen 1 as a lung metastasis protein through secretome analysis by Alečković, Maša, Wei, Yong, LeRoy, Gary, Sidoli, Simone, Liu, Daniel D, Garcia, Benjamin A, Kang, Yibin

“…Secreted proteins play crucial roles in mediating tumor-stroma interactions during metastasis of cancer to different target organs. To comprehensively profile…”
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Identification of Staphylococcal Nuclease Domain-containing 1 (SND1) as a Metadherin-interacting Protein with Metastasis-promoting Functions by Blanco, Mario Andres, Alečković, Maša, Hua, Yuling, Li, Tuo, Wei, Yong, Xu, Zhen, Cristea, Ileana M., Kang, Yibin

“…Metastasis is the deadliest and most poorly understood feature of malignant diseases. Recent work has shown that Metadherin (MTDH) is overexpressed in over 40%…”
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Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex by Fan, Jun, Shan, Changliang, Kang, Hee-Bum, Elf, Shannon, Xie, Jianxin, Tucker, Meghan, Gu, Ting-Lei, Aguiar, Mike, Lonning, Scott, Chen, Huaibin, Mohammadi, Moosa, Britton, Laura-Mae P., Garcia, Benjamin A., Alečković, Maša, Kang, Yibin, Kaluz, Stefan, Devi, Narra, Van Meir, Erwin G., Hitosugi, Taro, Seo, Jae Ho, Lonial, Sagar, Gaddh, Manila, Arellano, Martha, Khoury, Hanna J., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, Chen, Jing

“…Mitochondrial pyruvate dehydrogenase complex (PDC) is crucial for glucose homeostasis in mammalian cells. The current understanding of PDC regulation involves…”
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Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments by Janiszewska, Michalina, Tabassum, Doris P., Castaño, Zafira, Cristea, Simona, Yamamoto, Kimiyo N., Kingston, Natalie L., Murphy, Katherine C., Shu, Shaokun, Harper, Nicholas W., Del Alcazar, Carlos Gil, Alečković, Maša, Ekram, Muhammad B., Cohen, Ofir, Kwak, Minsuk, Qin, Yuanbo, Laszewski, Tyler, Luoma, Adrienne, Marusyk, Andriy, Wucherpfennig, Kai W., Wagle, Nikhil, Fan, Rong, Michor, Franziska, McAllister, Sandra S., Polyak, Kornelia

“…Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have…”
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JAK-STAT Signaling in Inflammatory Breast Cancer Enables Chemotherapy-Resistant Cell States by Stevens, Laura E, Peluffo, Guillermo, Qiu, Xintao, Temko, Daniel, Fassl, Anne, Li, Zheqi, Trinh, Anne, Seehawer, Marco, Jovanović, Bojana, Alečković, Maša, Wilde, Callahan M, Geck, Renee C, Shu, Shaokun, Kingston, Natalie L, Harper, Nicholas W, Almendro, Vanessa, Pyke, Alanna L, Egri, Shawn B, Papanastasiou, Malvina, Clement, Kendell, Zhou, Ningxuan, Walker, Sarah, Salas, Jacqueline, Park, So Yeon, Frank, David A, Meissner, Alexander, Jaffe, Jacob D, Sicinski, Piotr, Toker, Alex, Michor, Franziska, Long, Henry W, Overmoyer, Beth A, Polyak, Kornelia

“…Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. In…”
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Breast cancer prevention by short-term inhibition of TGFβ signaling by Alečković, Maša, Cristea, Simona, Gil Del Alcazar, Carlos R., Yan, Pengze, Ding, Lina, Krop, Ethan D., Harper, Nicholas W., Rojas Jimenez, Ernesto, Lu, Donghao, Gulvady, Anushree C., Foidart, Pierre, Seehawer, Marco, Diciaccio, Benedetto, Murphy, Katherine C., Pyrdol, Jason, Anand, Jayati, Garza, Kodie, Wucherpfennig, Kai W., Tamimi, Rulla M., Michor, Franziska, Polyak, Kornelia

“…Cancer prevention has a profound impact on cancer-associated mortality and morbidity. We previously identified TGFβ signaling as a candidate regulator of…”
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Combination Therapies to Improve the Efficacy of Immunotherapy in Triple-negative Breast Cancer by Alečković, Maša, Li, Zheqi, Zhou, Ningxuan, Qiu, Xintao, Lulseged, Bethlehem, Foidart, Pierre, Huang, Xiao-Yun, Garza, Kodie, Shu, Shaokun, Kesten, Nikolas, Li, Rong, Lim, Klothilda, Garrido-Castro, Ana C, Guerriero, Jennifer L, Qi, Jun, Long, Henry W, Polyak, Kornelia

“…Immune checkpoint inhibition combined with chemotherapy is currently approved as first-line treatment for patients with advanced PD-L1-positive triple-negative…”
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Click Chemistry Selectively Activates an Auristatin Protodrug with either Intratumoral or Systemic Tumor-Targeting Agents by McFarland, Jesse M., Alečković, Maša, Coricor, George, Srinivasan, Sangeetha, Tso, Matthew, Lee, John, Nguyen, Tri-Hung, Mejía Oneto, José M.

“…The Click Activated Protodrugs Against Cancer (CAPAC) platform enables the activation of powerful cancer drugs at tumors. CAPAC utilizes a click chemistry…”
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Global secretome analysis identifies novel mediators of bone metastasis by Blanco, Mario Andres, LeRoy, Gary, Khan, Zia, Alečković, Maša, Zee, Barry M, Garcia, Benjamin A, Kang, Yibin

“…Bone is the one of the most common sites of distant metastasis of solid tumors. Secreted proteins are known to influence pathological interactions between…”
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The impact of tumor epithelial and microenvironmental heterogeneity on treatment responses in HER2+ breast cancer by Janiszewska, Michalina, Stein, Shayna, Metzger Filho, Otto, Eng, Jennifer, Kingston, Natalie L, Harper, Nicholas W, Rye, Inga H, Alečković, Maša, Trinh, Anne, Murphy, Katherine C, Marangoni, Elisabetta, Cristea, Simona, Oakes, Benjamin, Winer, Eric P, Krop, Ian E, Russnes, Hege G, Spellman, Paul T, Bucher, Elmar, Hu, Zhi, Chin, Koei, Gray, Joe W, Michor, Franziska, Polyak, Kornelia

“…Despite the availability of multiple human epidermal growth factor receptor 2-targeted (HER2-targeted) treatments, therapeutic resistance in HER2+ breast…”
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Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation by Hitosugi, Taro, Zhou, Lu, Fan, Jun, Elf, Shannon, Zhang, Liang, Xie, Jianxin, Wang, Yi, Gu, Ting-Lei, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Kang, Hee-Bum, Seo, Jae-Ho, Shan, Changliang, Jin, Peng, Gong, Weimin, Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Chen, Georgia Z., Shin, Dong M., Khuri, Fadlo R., Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…How oncogenic signalling coordinates glycolysis and anabolic biosynthesis in cancer cells remains unclear. We recently reported that the glycolytic enzyme…”
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Is teratoma formation in stem cell research a characterization tool or a window to developmental biology? by Aleckovic, Masa, Simón, Carlos

“…Abstract Transplantation of pluripotent embryonic stem cells (ESC) into immune-deficient mice results in the formation of complex teratomas consisting of…”
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Bone marrow stroma-derived miRNAs as regulators, biomarkers and therapeutic targets of bone metastasis by Alečković, Maša, Kang, Yibin

“…MicroRNAs (miRNAs) are short, endogenous RNA molecules that have essential roles in regulating gene expression. They control numerous physiological and…”
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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers by Kim, Han Sang, Bojmar, Linda, Gyan, Kofi Ennu, Cioffi, Michele, Hernandez, Jonathan, Rodrigues, Gonçalo, Molina, Henrik, Heissel, Søren, Mark, Milica Tesic, Benito-Martin, Alberto, Lucotti, Serena, Di Giannatale, Angela, Offer, Katharine, Williams, Caitlin, Nogués, Laura, Davies, Alexander E., Kenific, Candia M., Buehring, Weston, Lauritzen, Pernille, Ogitani, Yusuke, Sugiura, Kei, Takahashi, Naoko, Alečković, Maša, Bailey, Kayleen A., Jolissant, Joshua S., Harris, Ashton, Schaeffer, L. Miles, García-Santos, Guillermo, Posner, Zoe, Balachandran, Vinod P., Raju, G. Praveen, Scherz, Avigdor, Sagi, Irit, Scherz-Shouval, Ruth, Yarden, Yosef, Oren, Moshe, Malladi, Mahathi, Petriccione, Mary, De Braganca, Kevin C., Donzelli, Maria, Fischer, Cheryl, Vitolano, Stephanie, Wright, Geraldine P., Ganshaw, Lee, Ahmed, Amina, DeStefano, Joe, Roehrl, Michael H.A., Lacayo, Norman J., Weiser, Martin R., Brady, Mary S., Meyers, Paul A., Ambati, Srikanth R., Chou, Alexander J., Slotkin, Emily K., Modak, Shakeel, Roberts, Stephen S., Basu, Ellen M., Diolaiti, Daniel, Krantz, Benjamin A., Cardoso, Fatima, Simpson, Amber L., Berger, Michael, Rudin, Charles M., Simeone, Diane M., Jain, Maneesh, Ghajar, Cyrus M., Batra, Surinder K., Stanger, Ben Z., Brown, Kristy A., Rajasekhar, Vinagolu K., Healey, John H., de Sousa, Maria, Kramer, Kim, Sheth, Sujit, Baisch, Jeanine, Pascual, Virginia, Heaton, Todd E., La Quaglia, Michael P., Pisapia, David J., Schwartz, Robert, Liu, Yuan, Shukla, Arti, Blavier, Laurence, DeClerck, Yves A., Bissell, Mina J., Caffrey, Thomas C., Grandgenett, Paul M., Hollingsworth, Michael A., Bromberg, Jacqueline, Costa-Silva, Bruno, Peinado, Hector, Kang, Yibin, Garcia, Benjamin A., O’Reilly, Eileen M., Kelsen, David, Trippett, Tanya M., Jones, David R., Matei, Irina R., Jarnagin, William R., Lyden, David

“…There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular…”
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Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth by Hitosugi, Taro, Zhou, Lu, Elf, Shannon, Fan, Jun, Kang, Hee-Bum, Seo, Jae Ho, Shan, Changliang, Dai, Qing, Zhang, Liang, Xie, Jianxin, Gu, Ting-Lei, Jin, Peng, Alečković, Masa, LeRoy, Gary, Kang, Yibin, Sudderth, Jessica A., DeBerardinis, Ralph J., Luan, Chi-Hao, Chen, Georgia Z., Muller, Susan, Shin, Dong M., Owonikoko, Taofeek K., Lonial, Sagar, Arellano, Martha L., Khoury, Hanna J., Khuri, Fadlo R., Lee, Benjamin H., Ye, Keqiang, Boggon, Titus J., Kang, Sumin, He, Chuan, Chen, Jing

“…It is unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate…”
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Interim phase 1 results for SQ3370 in advanced solid tumors by Chawla, Sant P., Batty, Kathleen, Aleckovic, Masa, Bhadri, Vivek, Bui, Nam, Guminski, Alexander David, Mejia Oneto, Jose Manuel, Srinivasan, Sangeetha, Strauss, James Fredric, Subbiah, Vivek, Weiss, Mia C., Wilson, Rosalind, Yee, Nathan A., Zakharian, Michael, Kwatra, Vineet

“…3085 Background: SQ3370, a novel therapy, utilizes Shasqi’s proprietary Click Activated Protodrugs Against Cancer (CAPAC) platform where mutually-reactive…”
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