Search Results - "Aldridge, Daniel L."

Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration by Balzer, Michael S., Doke, Tomohito, Yang, Ya-Wen, Aldridge, Daniel L., Hu, Hailong, Mai, Hung, Mukhi, Dhanunjay, Ma, Ziyuan, Shrestha, Rojesh, Palmer, Matthew B., Hunter, Christopher A., Susztak, Katalin

“…The kidney has tremendous capacity to repair after acute injury, however, pathways guiding adaptive and fibrotic repair are poorly understood. We developed a…”
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B cells promote CD8 T cell primary and memory responses to subunit vaccines by Klarquist, Jared, Cross, Eric W., Thompson, Scott B., Willett, Benjamin, Aldridge, Daniel L., Caffrey-Carr, Alayna K., Xu, Zhenming, Hunter, Christopher A., Getahun, Andrew, Kedl, Ross M.

“…The relationship between B cells and CD4 T cells has been carefully studied, revealing a collaborative effort in which B cells promote the activation,…”
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IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii by Clark, Joseph T., Weizman, Orr-El, Aldridge, Daniel L., Shallberg, Lindsey A., Eberhard, Julia, Lanzar, Zachary, Wasche, Devon, Huck, John D., Zhou, Ting, Ring, Aaron M., Hunter, Christopher A.

“…Interleukin-18 (IL-18) promotes natural killer (NK) and T cell production of interferon (IFN)-γ, a key factor in resistance to Toxoplasma gondii, but previous…”
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Endogenous IL-27 during toxoplasmosis limits early monocyte responses and their inflammatory activation by pathological T cells by Aldridge, Daniel L, Moodley, Devapregasan, Park, Jeongho, Phan, Anthony T, Rausch, Matthew, White, Kerry F, Ren, Yue, Golin, Karin, Radaelli, Enrico, Kedl, Ross, Holland, Pamela M, Hill, Jonathan, Hunter, Christopher A

“…Mice that lack the genes for IL-27, or the IL-27 receptor, and infected with develop T cell-mediated pathology. Here, studies were performed to determine the…”
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Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA by Taylor, Jared P, Armitage, Lucas H, Aldridge, Daniel L, Cash, Melanie N, Wallet, Mark A

“…Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-lived, latently-infected cells persist during prolonged antiretroviral…”
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Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis by Doke, Tomohito, Abedini, Amin, Aldridge, Daniel L., Yang, Ya-Wen, Park, Jihwan, Hernandez, Christina M., Balzer, Michael S., Shrestra, Rojesh, Coppock, Gaia, Rico, Juan M. Inclan, Han, Seung Yub, Kim, Junhyong, Xin, Sheng, Piliponsky, Adrian M., Angelozzi, Marco, Lefebvre, Veronique, Siracusa, Mark C., Hunter, Christopher A., Susztak, Katalin

“…Inflammation is an important component of fibrosis but immune processes that orchestrate kidney fibrosis are not well understood. Here we apply single-cell…”
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Limited Impact of the Inhibitory Receptor TIGIT on NK and T Cell Responses during Toxoplasma gondii Infection by Aldridge, Daniel L, Phan, Anthony T, de Waal Malefyt, Rene, Hunter, Christopher A

“…Resistance to the parasite is mediated by NK and T cell production of IFN-γ, but the failure to contract this response can lead to severe T cell-dependent…”
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