Search Results - "Aldrich, Richard"

Grey is the new black: covert action and implausible deniability by CORMAC, RORY, ALDRICH, RICHARD J.

“…For hundreds of years, states have sought to intervene in the affairs of others in a surreptitious manner. Since the professionalization of intelligence…”
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BK potassium channel modulation by leucine-rich repeat-containing proteins by Yan, Jiusheng, Aldrich, Richard W

“…Molecular diversity of ion channel structure and function underlies variability in electrical signaling in nerve, muscle, and nonexcitable cells. Regulation by…”
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LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium by Yan, Jiusheng, Aldrich, Richard W

“…Large-conductance, voltage- and calcium-activated potassium (BK, or KCa1.1) channels are ubiquitously expressed in electrically excitable and non-excitable…”
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Implications of a temperature-dependent heat capacity for temperature-gated ion channels by Yeh, Frank, Jara-Oseguera, Andrés, Aldrich, Richard W

“…Temperature influences dynamics and state-equilibrium distributions in all molecular processes, and only a relatively narrow range of temperatures is…”
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Determination of parameter identifiability in nonlinear biophysical models: A Bayesian approach by Hines, Keegan E, Middendorf, Thomas R, Aldrich, Richard W

“…A major goal of biophysics is to understand the physical mechanisms of biological molecules and systems. Mechanistic models are evaluated based on their…”
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Coordination to lanthanide ions distorts binding site conformation in calmodulin by Edington, Sean C., Gonzalez, Andrea, Middendorf, Thomas R., Halling, D. Brent, Aldrich, Richard W., Baiz, Carlos R.

“…The Ca2+-sensing protein calmodulin (CaM) is a popular model of biological ion binding since it is both experimentally tractable and essential to survival in…”
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Influences: Growing up in Yale Physiology by Aldrich, Richard W

“…Aldrich recounts the unique influence that the Yale Physiology Department had on his early career…”
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Conserved properties of individual Ca2+-binding sites in calmodulin by Halling, D. Brent, Liebeskind, Benjamin J., Hall, Amelia W., Aldrich, Richard W.

“…Calmodulin (CaM) is a Ca2+-sensing protein that is highly conserved and ubiquitous in eukaryotes. In humans it is a locus of life-threatening cardiomyopathies…”
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Ancestral reconstruction of protein interaction networks by Liebeskind, Benjamin J, Aldrich, Richard W, Marcotte, Edward M

“…The molecular and cellular basis of novelty is an active area of research in evolutionary biology. Until very recently, the vast majority of cellular phenomena…”
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International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels by Kaczmarek, Leonard K, Aldrich, Richard W, Chandy, K George, Grissmer, Stephan, Wei, Aguan D, Wulff, Heike

“…A subset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons…”
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Secrecy, spies and the global South: intelligence studies beyond the ‘Five Eyes’ alliance by Shiraz, Zakia, Aldrich, Richard J.

“…Abstract The study of secrecy and spies remain subjects dominated by Anglo-American experiences. In recent years there has been some effort to refocus the lens…”
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From sigint to cyber: a hundred years of Britain's biggest intelligence agency by Aldrich, Richard J.

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Secrets, spies and editors in Cold War America: Ben Bradlee and the Washington Post by Aldrich, Richard J.

“…This essay considers secrets, spies and newspaper editors in the context of the Washington Post's relationship with the CIA. The associated relationships and…”
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Analyzing Single-Molecule Time Series via Nonparametric Bayesian Inference by Hines, Keegan E., Bankston, John R., Aldrich, Richard W.

“…The ability to measure the properties of proteins at the single-molecule level offers an unparalleled glimpse into biological systems at the molecular scale…”
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Ambient accountability: intelligence services in Europe and the decline of state secrecy by Aldrich, Richard J., Richterova, Daniela

“…In the 1990s, judgments in the European Court of Human Rights concerning state surveillance forced many West European countries to introduce new parliamentary…”
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Astrocytic endfoot Ca²⁺ and BK channels determine both arteriolar dilation and constriction by Girouard, Hélène, Bonev, Adrian D, Hannah, Rachael M, Meredith, Andrea, Aldrich, Richard W, Nelson, Mark T

“…Neuronal activity is thought to communicate to arterioles in the brain through astrocytic calcium (Ca²⁺) signaling to cause local vasodilation. Paradoxically,…”
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Closed state-coupled C-type inactivation in BK channels by Yan, Jiusheng, Li, Qin, Aldrich, Richard W.

“…Ion channels regulate ion flow by opening and closing their pore gates. K⁺ channels commonly possess two pore gates, one at the intracellular end for fast…”
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Cryptography and the Global South: secrecy, signals and information imperialism by Dover, Robert, Aldrich, Richard J.

“…For decades, espionage during the Cold War was often presented as a competition between East and West. The extent to which the Global South constituted the…”
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BK channel opening involves side-chain reorientation of multiple deep-pore residues by Chen, Xixi, Yan, Jiusheng, Aldrich, Richard W

“…Three deep-pore locations, L312, A313, and A316, were identified in a scanning mutagenesis study of the BK (Ca ²⁺-activated, large-conductance K ⁺) channel S6…”
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The Concise Guide to PHARMACOLOGY 2023/24: Ion channels by Alexander, Stephen P. H., Mathie, Alistair A., Peters, John A., Veale, Emma L., Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Aldrich, Richard W., Attali, Bernard, Baggetta, Austin M., Becirovic, Elvir, Biel, Martin, Bill, Roslyn M., Caceres, Ana I., Catterall, William A., Conner, Alex C., Davies, Paul, De Clerq, Katrien, Delling, Markus, Di Virgilio, Francesco, Falzoni, Simonetta, Fenske, Stefanie, Fortuny‐Gomez, Anna, Fountain, Samuel, George, Chandy, Goldstein, Steve A. N., Grimm, Christian, Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Hu, Meiqin, Ijzerman, Ad P., Jabba, Sairam V., Jarvis, Mike, Jensen, Anders A., Jordt, Sven E., Kaczmarek, Leonard K., Kellenberger, Stephan, Kennedy, Charles, King, Brian, Kitchen, Philip, Liu, Qiang, Lynch, Joseph W., Meades, Jessica, Mehlfeld, Verena, Nicke, Annette, Offermanns, Stefan, Perez‐Reyes, Edward, Plant, Leigh D., Rash, Lachlan, Ren, Dejian, Salman, Mootaz M., Sieghart, Werner, Sivilotti, Lucia G., Smart, Trevor G., Snutch, Terrance P., Tian, Jinbin, Trimmer, James S., Van den Eynde, Charlotte, Vriens, Joris, Wei, Aguan D., Winn, Brenda T., Wulff, Heike, Xu, Haoxing, Yang, Fan, Fang, Wei, Yue, Lixia, Zhang, Xiaoli, Zhu, Michael

“…The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular…”
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