Search Results - "Aldrich, E. Francois"

A sustained systemic inflammatory response syndrome is associated with shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage by Wessell, Aaron P, Kole, Matthew J, Cannarsa, Gregory, Oliver, Jeffrey, Jindal, Gaurav, Miller, Timothy, Gandhi, Dheeraj, Parikh, Gunjan, Badjatia, Neeraj, Aldrich, E Francois, Simard, J Marc

“…The authors sought to evaluate whether a sustained systemic inflammatory response was associated with shunt-dependent hydrocephalus following aneurysmal…”
Get full text

Thick and Diffuse Subarachnoid Blood as a Treatment Effect Modifier of Clazosentan After Subarachnoid Hemorrhage by Mayer, Stephan A, Aldrich, E Francois, Bruder, Nicolas, Hmissi, Abdel, Macdonald, R Loch, Viarasilpa, Tanuwong, Marr, Angelina, Roux, Sebastien, Higashida, Randall T

“…BACKGROUND AND PURPOSE—Clazosentan, an endothelin receptor antagonist, has been shown to reduce angiographic vasospasm and vasospasm-related morbidity after…”
Get full text

Unfractionated Heparin: Multitargeted Therapy for Delayed Neurological Deficits Induced by Subarachnoid Hemorrhage by Simard, J. Marc, Schreibman, David, Aldrich, E. Francois, Stallmeyer, Bernadette, Le, Brian, James, Robert F., Beaty, Narlin

“…Aneurysmal subarachnoid hemorrhage (SAH) is associated with numerous “delayed neurological deficits” (DNDs) that have been attributed to multiple…”
Get full text

Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial by Hanley, Daniel F, Prof, Lane, Karen, CMA, McBee, Nichol, MPH, Ziai, Wendy, MD, Tuhrim, Stanley, Prof, Lees, Kennedy R, Prof, Dawson, Jesse, MD, Gandhi, Dheeraj, MD, Ullman, Natalie, MPH, Mould, W Andrew, MPHc, Mayo, Steven W, PD, Mendelow, A David, Prof, Gregson, Barbara, PhD, Butcher, Kenneth, Prof, Vespa, Paul, Prof, Wright, David W, MD, Kase, Carlos S, Prof, Carhuapoma, J Ricardo, MD, Keyl, Penelope M, PhD, Diener-West, Marie, Prof, Muschelli, John, PhD, Betz, Joshua F, MS, Thompson, Carol B, MS, Sugar, Elizabeth A, PhD, Yenokyan, Gayane, PhD, Janis, Scott, PhD, John, Sayona, MD, Harnof, Sagi, MD, Lopez, George A, MD, Aldrich, E Francois, Prof, Harrigan, Mark R, MD, Ansari, Safdar, MD, Jallo, Jack, Prof, Caron, Jean-Louis, Prof, LeDoux, David, MD, Adeoye, Opeolu, MD, Zuccarello, Mario, Prof, Adams, Harold P, Prof, Rosenblum, Michael, PhD, Thompson, Richard E, PhD, Awad, Issam A, Prof

“…Summary Background Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and serious disability for survivors. We aimed to…”
Get full text

Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial by Hanley, Daniel F, Prof, Thompson, Richard E, PhD, Muschelli, John, PhD, Rosenblum, Michael, PhD, McBee, Nichol, MPH, Lane, Karen, CMA, Bistran-Hall, Amanda J, BS, Mayo, Steven W, PD, Keyl, Penelope, PhD, Gandhi, Dheeraj, MD, Morgan, Tim C, MPH, Ullman, Natalie, MPH, Mould, W Andrew, BA, Carhuapoma, J Ricardo, MD, Kase, Carlos, MD, Ziai, Wendy, MD, Thompson, Carol B, MS, Yenokyan, Gayane, PhD, Huang, Emily, PhD, Broaddus, William C, MD, Graham, R Scott, MD, Aldrich, E Francois, MD, Dodd, Robert, MD, Wijman, Cristanne, MD, Caron, Jean-Louis, MD, Huang, Judy, MD, Camarata, Paul, MD, Mendelow, A David, FRCS[SN], Gregson, Barbara, PhD, Janis, Scott, PhD, Vespa, Paul, MD, Martin, Neil, MD, Awad, Issam, Prof, Zuccarello, Mario, Prof

“…Summary Background Craniotomy, according to the results from trials, does not improve functional outcome after intracerebral haemorrhage. Whether minimally…”
Get full text

Thick and diffuse cisternal clot independently predicts vasospasm-related morbidity and poor outcome after aneurysmal subarachnoid hemorrhage by Aldrich, E François, Higashida, Randall, Hmissi, Abdel, Le, Elizabeth J, Macdonald, R Loch, Marr, Angelina, Mayer, Stephan A, Roux, Sébastien, Bruder, Nicolas

“…Aneurysmal subarachnoid hemorrhage (aSAH) is associated with significant morbidity and mortality. The presence of thick, diffuse subarachnoid blood may portend…”
Get full text

The REACT study: design of a randomized phase 3 trial to assess the efficacy and safety of clazosentan for preventing deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage by Bruder, Nicolas, Higashida, Randall, Santin-Janin, Hugues, Dubois, Cécile, Aldrich, E François, Marr, Angelina, Roux, Sébastien, Mayer, Stephan A

“…For patients presenting with an aneurysmal subarachnoid hemorrhage (aSAH), delayed cerebral ischemia (DCI) is a significant cause of morbidity and mortality…”
Get full text

Low-Dose Intravenous Heparin Infusion After Aneurysmal Subarachnoid Hemorrhage is Associated With Decreased Risk of Delayed Neurological Deficit and Cerebral Infarction by Kole, Matthew J, Wessell, Aaron P, Ugiliweneza, Beatrice, Cannarsa, Gregory J, Fortuny, Enzo, Stokum, Jesse A, Shea, Phelan, Chryssikos, Timothy, Khattar, Nicolas K, Crabill, George A, Schreibman, David L, Badjatia, Neeraj, Gandhi, Dheeraj, Aldrich, E Francois, James, Robert F, Simard, J Marc

“…Abstract BACKGROUND Patients who survive aneurysmal subarachnoid hemorrhage (aSAH) are at risk for delayed neurological deficits (DND) and cerebral infarction…”
Get full text

Utility of the Hijdra Sum Score in Predicting Risk of Aneurysm in Patients With Subarachnoid Hemorrhage: A Single-Center Experience With 550 Patients by Kole, Matthew J, Shea, Phelan, Albrecht, Jennifer S, Cannarsa, Gregory J, Wessell, Aaron P, Miller, Timothy R, Jindal, Gaurav, Gandhi, Dheeraj, Aldrich, E Francois, Simard, J Marc

“…Abstract BACKGROUND Subarachnoid hemorrhage (SAH) is most commonly caused by a ruptured vascular lesion. A significant number of patients presenting with SAH…”
Get full text

NEWTON-2 Cisternal (Nimodipine Microparticles to Enhance Recovery While Reducing Toxicity After Subarachnoid Hemorrhage): A Phase 2, Multicenter, Randomized, Open-Label Safety Study of Intracisternal EG-1962 in Aneurysmal Subarachnoid Hemorrhage by Macdonald, R Loch, Hänggi, Daniel, Ko, Nerissa U, Darsaut, Tim E, Carlson, Andrew P, Wong, George K, Etminan, Nima, Mayer, Stephan A, Aldrich, E Francois, Diringer, Michael N, Ng, David, Strange, Poul, Bleck, Thomas, Grubb, Robert, Suarez, Jose I

“…ABSTRACT BACKGROUND A sustained release microparticle formulation of nimodipine (EG-1962) was developed for treatment of patients with aneurysmal subarachnoid…”
Get full text

Clinical Trial Protocol: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy, and Safety Study Comparing EG-1962 to Standard of Care Oral Nimodipine in Adults with Aneurysmal Subarachnoid Hemorrhage [NEWTON-2 (Nimodipine Microparticles to Enhance Recovery While Reducing TOxicity After SubarachNoid Hemorrhage)] by Hänggi, Daniel, Etminan, Nima, Mayer, Stephan A., Aldrich, E. Francois, Diringer, Michael N., Schmutzhard, Erich, Faleck, Herbert J., Ng, David, Saville, Benjamin R., Macdonald, R. Loch

“…Background Nimodipine is the only drug approved in the treatment of aneurysmal subarachnoid hemorrhage (aSAH) in many countries. EG-1962, a product developed…”
Get full text

Reversal of Vasospasm with Clazosentan After Aneurysmal Subarachnoid Hemorrhage: A Pilot Study by Higashida, Randall T., Bruder, Nicolas, Gupta, Rajiv, Guzman, Raphael, Hmissi, Abdel, Marr, Angelina, Mayer, Stephan A., Roux, Sébastien, Weidauer, Stefan, Aldrich, E. François

“…Clazosentan, an endothelin-1 receptor antagonist, has been shown to prevent the development of large vessel angiographic vasospasm after aneurysmal…”
Get full text

Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment by Simard, J Marc, Aldrich, E Francois, Schreibman, David, James, Robert F, Polifka, Adam, Beaty, Narlin

“…Aneurysmal subarachnoid hemorrhage (aSAH) predisposes to delayed neurological deficits, including stroke and cognitive and neuropsychological abnormalities…”
Get full text

Occipital bone abnormality causing recurrent posterior circulation strokes by Cronin, Carolyn A, Aldrich, E Francois, Kittner, Steven J

“…We report the case of a young man with recurrent posterior circulation strokes over the course of 6 years. Standard stroke evaluation was unremarkable until…”
Get full text

Treatment of cerebral aneurysms-surgical clipping or endovascular coiling: the guiding principles by Shivashankar, Ravishankar, Miller, Timothy R, Jindal, Gaurav, Simard, J Marc, Aldrich, E Francois, Gandhi, Dheeraj

“…Cerebral aneurysms represent common intracranial vascular lesions encountered in neurosurgical practice. The clinical presentation is varied, ranging from…”
Get more information

Long-term outcome of Gamma Knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classification by Koltz, Michael T, Polifka, Adam J, Saltos, Andreas, Slawson, Robert G, Kwok, Young, Aldrich, E Francois, Simard, J Marc

“…The object of this study was to assess outcomes in patients with arteriovenous malformations (AVMs) treated by Gamma Knife stereotactic radiosurgery (SRS);…”
Get full text

Low-dose intravenous heparin infusion in patients with aneurysmal subarachnoid hemorrhage: a preliminary assessment: Clinical article by Simard, J. Marc, Aldrich, E. Francois, Schreibman, David, James, Robert F., Polifka, Adam, Beaty, Narlin

Get full text

Diffuse brain swelling in severely head-injured children : a report from the NIH traumatic coma data bank by FRANCOIS ALDRICH, E, EISENBERG, H. M, SAYDJARI, C, LUERSSEN, T. G, FOULKES, M. A, JANE, J. A, MARSHALL, L. F, MARMAROU, A, YOUNG, H. F

“…In this study, data were prospectively collected from 753 patients (111 children and 642 adults) with severe head injury and examined for evidence of diffuse…”
Get full text

Intrachiasmal Craniopharyngioma: Treatment with a Cisternal Catheter Drainage and Radiation by Pomeranz, Howard D, Aldrich, E Francois

“…A 54-year-old woman who presented with headaches and bitemporal visual field loss had an MRI that disclosed a cystic lesion within the optic chiasm. Craniotomy…”
Get full text

Long-term outcome of Gamma Knife stereotactic radiosurgery for arteriovenous malformations graded by the Spetzler-Martin classification: Clinical article by Koltz, Michael T., Polifka, Adam J., Saltos, Andreas, Slawson, Robert G., Kwok, Young, Aldrich, E. Francois, Simard, J. Marc

Get full text