Search Results - "Aldrich, Courtney C."

Mitsunobu Reactions Catalytic in Phosphine and a Fully Catalytic System by Buonomo, Joseph A., Aldrich, Courtney C.

“…The Mitsunobu reaction is renowned for its mild reaction conditions and broad substrate tolerance, but has limited utility in process chemistry and industrial…”
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Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole by Minato, Yusuke, Dawadi, Surendra, Kordus, Shannon L., Sivanandam, Abiram, Aldrich, Courtney C., Baughn, Anthony D.

“…Trimethoprim (TMP)-sulfamethoxazole (SMX) is a widely used synergistic antimicrobial combination to treat a variety of bacterial and certain fungal infections…”
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Structures of two distinct conformations of holo-non-ribosomal peptide synthetases by Drake, Eric J., Miller, Bradley R., Shi, Ce, Tarrasch, Jeffrey T., Sundlov, Jesse A., Leigh Allen, C., Skiniotis, Georgios, Aldrich, Courtney C., Gulick, Andrew M.

“…X-ray crystal structures of two distinct steps in the catalytic cycle of non-ribosomal peptide synthetases are described, offering the potential to generate…”
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Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture by Miller, Bradley R., Drake, Eric J., Shi, Ce, Aldrich, Courtney C., Gulick, Andrew M.

“…Nonribosomal peptide synthetases (NRPSs) produce a wide variety of peptide natural products. During synthesis, the multidomain NRPSs act as an assembly line,…”
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Development of an imidazole salt catalytic system for the preparation of bis(indolyl)methanes and bis(naphthyl)methane by Wang, Xu, Aldrich, Courtney C

“…Imidazolium salts are shown to catalyze the rapid room temperature reaction of indoles or naphthol with aldehydes to provide bis(indolyl)methanes or…”
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Chemoselective Reduction of Phosphine Oxides by 1,3‐Diphenyl‐Disiloxane by Buonomo, Joseph A., Eiden, Carter G., Aldrich, Courtney C.

“…Reduction of phosphine oxides to the corresponding phosphines represents the most straightforward method to prepare these valuable reagents. However, existing…”
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Whole-Cell Screen of Fragment Library Identifies Gut Microbiota Metabolite Indole Propionic Acid as Antitubercular by Negatu, Dereje A, Liu, Joe J J, Zimmerman, Matthew, Kaya, Firat, Dartois, Véronique, Aldrich, Courtney C, Gengenbacher, Martin, Dick, Thomas

“…Several key antituberculosis drugs, including pyrazinamide, with a molecular mass of 123.1 g/mol, are smaller than the usual drug-like molecules. Current drug…”
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Structure of PA1221, a Nonribosomal Peptide Synthetase Containing Adenylation and Peptidyl Carrier Protein Domains by Mitchell, Carter A, Shi, Ce, Aldrich, Courtney C, Gulick, Andrew M

“…Many bacteria use large modular enzymes for the synthesis of polyketide and peptide natural products. These multidomain enzymes contain integrated carrier…”
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Parameterization and Application of the General Amber Force Field to Model Fluoro Substituted Furanose Moieties and Nucleosides by Escalante, Diego E, Aldrich, Courtney C, Ferguson, David M

“…Molecular mechanics force field calculations have historically shown significant limitations in modeling the energetic and conformational interconversions of…”
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A continuous kinetic assay for adenylation enzyme activity and inhibition by Wilson, Daniel J., Aldrich, Courtney C.

“…Adenylation/adenylate-forming enzymes catalyze the activation of a carboxylic acid at the expense of ATP to form an acyl-adenylate intermediate and…”
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Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin by Qu, Di, Ge, Peng, Botella, Laure, Park, Sae Woong, Lee, Ha-Na, Thornton, Natalie, Bean, James M., Krieger, Inna V., Sacchettini, James C., Ehrt, Sabine, Aldrich, Courtney C., Schnappinger, Dirk

“…Lipid biosynthesis in the pathogen Mycobacterium tuberculosis depends on biotin for posttranslational modification of key enzymes. However, the mycobacterial…”
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Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression by Woong Park, Sae, Klotzsche, Marcus, Wilson, Daniel J, Boshoff, Helena I, Eoh, Hyungjin, Manjunatha, Ujjini, Blumenthal, Antje, Rhee, Kyu, Barry, 3rd, Clifton E, Aldrich, Courtney C, Ehrt, Sabine, Schnappinger, Dirk

“…In the search for new drug targets, we evaluated the biotin synthetic pathway of Mycobacterium tuberculosis (Mtb) and constructed an Mtb mutant lacking the…”
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genetic strategy to identify targets for the development of drugs that prevent bacterial persistence by Kim, Jee-Hyun, O'Brien, Kathryn M., Sharma, Ritu, Boshoff, Helena I. M., Rehren, German, Chakraborty, Sumit, Wallach, Joshua B., Monteleone, Mercedes, Wilson, Daniel J., Aldrich, Courtney C., Barry, Clifton E., Rhee, Kyu Y., Ehrt, Sabine, Schnappinger, Dirk

“…Antibacterial drug development suffers from a paucity of targets whose inhibition kills replicating and nonreplicating bacteria. The latter include…”
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Fluorescence lifetime FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators by Roopnarine, Osha, Yuen, Samantha L., Thompson, Andrew R., Roelike, Lauren N., Rebbeck, Robyn T., Bidwell, Philip A., Aldrich, Courtney C., Cornea, Razvan L., Thomas, David D.

“…We have used FRET-based biosensors in live cells, in a robust high-throughput screening (HTS) platform, to identify small-molecules that alter the structure…”
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Adenylating enzymes in Mycobacterium tuberculosis as drug targets by Duckworth, Benjamin P, Nelson, Kathryn M, Aldrich, Courtney C

“…Adenylation or adenylate-forming enzymes (AEs) are widely found in nature and are responsible for the activation of carboxylic acids to intermediate…”
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Metabolically distinct roles of NAD synthetase and NAD kinase define the essentiality of NAD and NADP in Mycobacterium tuberculosis by Sharma, Ritu, Hartman, Travis E, Beites, Tiago, Kim, Jee-Hyun, Eoh, Hyungjin, Engelhart, Curtis A, Zhu, Linnan, Wilson, Daniel J, Aldrich, Courtney C, Ehrt, Sabine, Rhee, Kyu Young, Schnappinger, Dirk

“…Nicotinamide adenine dinucleotide (NAD) and its phosphorylated derivative (NADP) are essential cofactors that participate in hundreds of biochemical reactions…”
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Psoralen Derivatives as Inhibitors of Mycobacterium tuberculosis Proteasome by Rožman, Kaja, Alexander, Evan M, Ogorevc, Eva, Bozovičar, Krištof, Sosič, Izidor, Aldrich, Courtney C, Gobec, Stanislav

“…Protein degradation is a fundamental process in all living organisms. An important part of this system is a multisubunit, barrel-shaped protease complex called…”
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Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis by Dawadi, Surendra, Viswanathan, Kishore, Boshoff, Helena I, Barry, Clifton E, Aldrich, Courtney C

“…Antibiotic resistance represents one of the greatest threats to public health. The adenylation inhibitor 5′-O-[N-(salicyl)­sulfamoyl]­adenosine (SAL-AMS) is…”
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Blocking ADP-ribosylation expands the anti-mycobacterial spectrum of rifamycins by Ganapathy, Uday S, Lan, Tian, Dartois, Véronique, Aldrich, Courtney C, Dick, Thomas

“…The clinical utility of rifamycins against non-tuberculous mycobacterial (NTM) disease is limited by intrinsic drug resistance achieved by…”
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Design, Synthesis, and Biophysical Evaluation of Mechanism-Based Probes for Condensation Domains of Nonribosomal Peptide Synthetases by Shi, Ce, Miller, Bradley R, Alexander, Evan M, Gulick, Andrew M, Aldrich, Courtney C

“…Nonribosomal peptide synthetases (NRPSs) are remarkable modular enzymes that synthesize peptide natural products. The condensation (C) domain catalyzes the key…”
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