Search Results - "Aldinucci, Donatella"

The Inflammatory Chemokine CCL5 and Cancer Progression by Aldinucci, Donatella, Colombatti, Alfonso

“…Until recently, inflammatory chemokines were viewed mainly as indispensable “gate keepers” of immunity and inflammation. However, updated research indicates…”
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Inhibition of the CCL5/CCR5 Axis against the Progression of Gastric Cancer by Aldinucci, Donatella, Casagrande, Naike

“…Despite the progress made in molecular and clinical research, patients with advanced-stage gastric cancer (GC) have a bad prognosis and very low survival…”
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The CCL5/CCR5 Axis in Cancer Progression by Aldinucci, Donatella, Borghese, Cinzia, Casagrande, Naike

“…Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5)…”
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Formation of the Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It by Aldinucci, Donatella, Borghese, Cinzia, Casagrande, Naike

“…Classic Hodgkin lymphoma (cHL) is characterized by a few tumor cells surrounded by a protective, immunosuppressive tumor microenvironment composed of normal…”
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CCR5 antagonism by maraviroc inhibits Hodgkin lymphoma microenvironment interactions and xenograft growth by Casagrande, Naike, Borghese, Cinzia, Visser, Lydia, Mongiat, Maurizio, Colombatti, Alfonso, Aldinucci, Donatella

“…Classic Hodgkin lymphoma tumor cells express a functional CCR5 receptor, and tumor tissues express high CCL5 levels, suggesting that CCL5-CCR5 signaling is…”
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In ovarian cancer maraviroc potentiates the antitumoral activity and further inhibits the formation of a tumor-promoting microenvironment by trabectedin by Casagrande, Naike, Borghese, Cinzia, Corona, Giuseppe, Aldinucci, Donatella

“…Ovarian cancer (OC) is the fifth most frequent cause of cancer-related death in women. Chemotherapy agent trabectedin, affecting cancer cells and tumor…”
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In classical Hodgkin lymphoma the combination of the CCR5 antagonist maraviroc with trabectedin synergizes, enhances DNA damage and decreases three-dimensional tumor-stroma heterospheroid viability by Casagrande, Naike, Borghese, Cinzia, Aldinucci, Donatella

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In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel by Casagrande, Naike, Borghese, Cinzia, Agostini, Francesco, Durante, Cristina, Mazzucato, Mario, Colombatti, Alfonso, Aldinucci, Donatella

“…A high platelet count is associated with a poor prognosis in ovarian cancer (OvCa). Despite good clinical responses with platinating agents in combination with…”
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Analogs of a Natural Peptaibol Exert Anticancer Activity in Both Cisplatin- and Doxorubicin-Resistant Cells and in Multicellular Tumor Spheroids by Casagrande, Naike, Borghese, Cinzia, Gabbatore, Laura, Morbiato, Laura, De Zotti, Marta, Aldinucci, Donatella

“…Peptaibols, by disturbing the permeability of phospholipid membranes, can overcome anticancer drug resistance, but their natural hydrophobicity hampers their…”
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Adipose-Derived Stem Cells Primed with Paclitaxel Inhibit Ovarian Cancer Spheroid Growth and Overcome Paclitaxel Resistance by Borghese, Cinzia, Casagrande, Naike, Corona, Giuseppe, Aldinucci, Donatella

“…Adipose-derived stem cells (ADSCs) primed with paclitaxel (PTX) are now hypothesized to represent a potential Trojan horse to vehicle and deliver PTX into…”
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The role of the EGFR signaling in tumor microenvironment by De Luca, Antonella, Carotenuto, Adele, Rachiglio, Annamaria, Gallo, Marianna, Maiello, Monica R., Aldinucci, Donatella, Pinto, Antonio, Normanno, Nicola

“…The epidermal growth factor receptor (EGFR) family comprehends four different tyrosine kinases (EGFR, ErbB‐2, ErbB‐3, and ErbB‐4) that are activated following…”
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In Doxorubicin-Adapted Hodgkin Lymphoma Cells, Acquiring Multidrug Resistance and Improved Immunosuppressive Abilities, Doxorubicin Activity Was Enhanced by Chloroquine and GW4869 by Casagrande, Naike, Borghese, Cinzia, Avanzo, Michele, Aldinucci, Donatella

“…Classical Hodgkin lymphoma (cHL) is a highly curable disease (70-80%), even though long-term toxicities, drug resistance, and predicting clinical responses to…”
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Dinuclear gold(I) complexes based on carbene and diphosphane ligands: bis[2-(dicyclohexylphosphano)ethyl]amine complex inhibits the proteasome activity, decreases stem cell markers and spheroid viability in lung cancer cells by Casagrande, Naike, Borghese, Cinzia, Corona, Giuseppe, Aldinucci, Donatella, Altaf, Muhammad, Sulaiman, Adam A. A., Isab, Anvarhusein A., Ahmad, Saeed, Peedikakkal, Abdul Malik P.

“…Three new dinuclear gold(I) complexes ( 1 – 3 ) containing a carbene (1,3-Bis(2,6-di-isopropylphenyl)imidazol-2-ylidene (IPr)) and diphosphane ligands…”
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Expression of CCR5 receptors on Reed–Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions by Aldinucci, Donatella, Lorenzon, Debora, Cattaruzza, Lara, Pinto, Antonio, Gloghini, Annunziata, Carbone, Antonino, Colombatti, Alfonso

“…The expression of CCL5/Rantes by Hodgkin (H) and Reed‐Sternberg (RS) cells has been recently documented. In the present study we demonstrated that the CCL5…”
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Role of the EGFR ligand/receptor system in the secretion of angiogenic factors in mesenchymal stem cells by De Luca, Antonella, Gallo, Marianna, Aldinucci, Donatella, Ribatti, Domenico, Lamura, Luana, D'Alessio, Amelia, De Filippi, Rosaria, Pinto, Antonio, Normanno, Nicola

“…Increasing evidence suggests that bone marrow‐derived mesenchymal stem cells (MSCs) are recruited into the stroma of developing tumors where they contribute to…”
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Improved GMP compliant approach to manipulate lipoaspirates, to cryopreserve stromal vascular fraction, and to expand adipose stem cells in xeno-free media by Agostini, Francesco, Rossi, Francesca Maria, Aldinucci, Donatella, Battiston, Monica, Lombardi, Elisabetta, Zanolin, Stefania, Massarut, Samuele, Parodi, Pier Camillo, Da Ponte, Alessandro, Tessitori, Giovanni, Pivetta, Barbara, Durante, Cristina, Mazzucato, Mario

“…The stromal vascular fraction (SVF) derived from adipose tissue contains adipose-derived stromal/stem cells (ASC) and can be used for regenerative…”
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Latest insights into the anticancer activity of gold(III)-dithiocarbamato complexes by Ronconi, Luca, Aldinucci, Donatella, Dou, Q Ping, Fregona, Dolores

“…In this review paper we aim at giving a detailed overview on our research work devoted to the design of gold-based anticancer agents. In particular, during the…”
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Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity by Borghese, Cinzia, Cattaruzza, Lara, Pivetta, Eliana, Normanno, Nicola, De Luca, Antonella, Mazzucato, Mario, Celegato, Marta, Colombatti, Alfonso, Aldinucci, Donatella

“…Increasing evidence suggests that bone marrow derived mesenchymal stem cells (BM‐MSCs) are recruited into the stroma of developing tumors where they contribute…”
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Functional coexpression of Interleukin (IL)‐7 and its receptor (IL‐7R) on Hodgkin and Reed‐Sternberg cells: Involvement of IL‐7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma by Cattaruzza, Lara, Gloghini, Annunziata, Olivo, Karin, Di Francia, Raffaele, Lorenzon, Debora, De Filippi, Rosaria, Carbone, Antonino, Colombatti, Alfonso, Pinto, Antonio, Aldinucci, Donatella

“…The clinical and pathological features of classical Hodgkin lymphoma (cHL) mirror an abnormal tissue and systemic immune response due to the production of a…”
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Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts by Celegato, Marta, Borghese, Cinzia, Casagrande, Naike, Carbone, Antonino, Colombatti, Alfonso, Aldinucci, Donatella

“…Abstract Bortezomib is a proteasome inhibitor active in classical Hodgkin lymphoma (cHL) cell lines, but poorly active in the clinic when used as a single…”
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