Search Results - "Alderson, T"

NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function by Alderson, T. Reid, Kay, Lewis E.

“…Biomolecules are in constant motion. To understand how they function, and why malfunctions can cause disease, it is necessary to describe their…”
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Unveiling invisible protein states with NMR spectroscopy by Alderson, T Reid, Kay, Lewis E

“…[Display omitted] •Sparsely populated protein states can play significant biological roles.•NMR spectroscopy can structurally and dynamically characterize…”
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Study of protein folding under native conditions by rapidly switching the hydrostatic pressure inside an NMR sample cell by Charlier, Cyril, Alderson, T. Reid, Courtney, Joseph M., Ying, Jinfa, Anfinrud, Philip, Bax, Adriaan

“…In general, small proteins rapidly fold on the timescale of milliseconds or less. For proteins with a substantial volume difference between the folded and…”
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Systematic identification of conditionally folded intrinsically disordered regions by AlphaFold2 by Alderson, T Reid, Pritišanac, Iva, Kolarić, Đesika, Moses, Alan M, Forman-Kay, Julie D

“…The AlphaFold Protein Structure Database contains predicted structures for millions of proteins. For the majority of human proteins that contain intrinsically…”
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Local unfolding of the HSP27 monomer regulates chaperone activity by Alderson, T. Reid, Roche, Julien, Gastall, Heidi Y., Dias, David M., Pritišanac, Iva, Ying, Jinfa, Bax, Ad, Benesch, Justin L. P., Baldwin, Andrew J.

“…The small heat-shock protein HSP27 is a redox-sensitive molecular chaperone that is expressed throughout the human body. Here, we describe redox-induced…”
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Automatic structure-based NMR methyl resonance assignment in large proteins by Pritišanac, Iva, Würz, Julia M., Alderson, T. Reid, Güntert, Peter

“…Isotopically labeled methyl groups provide NMR probes in large, otherwise deuterated proteins. However, the resonance assignment constitutes a bottleneck for…”
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A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins by Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin

“…HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause…”
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Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR by Sever, Alexander I M, Alderson, T Reid, Rennella, Enrico, Aramini, James M, Liu, Zi Hao, Harkness, Robert W, Kay, Lewis E

“…Mitochondrial apoptotic signaling cascades lead to the formation of the apoptosome, a 1.1-MDa heptameric protein scaffold that recruits and activates the…”
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Automated assignment of methyl NMR spectra from large proteins by Pritišanac, Iva, Alderson, T. Reid, Güntert, Peter

“…[Display omitted] •Methyl labeling enables NMR to study large proteins and molecular assemblies.•Assignment of methyl groups is a bottleneck for methyl NMR.•We…”
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Propensity for cis‐Proline Formation in Unfolded Proteins by Alderson, T. Reid, Lee, Jung Ho, Charlier, Cyril, Ying, Jinfa, Bax, Ad

“…In unfolded proteins, peptide bonds involving Pro residues exist in equilibrium between the minor cis and major trans conformations. Folded proteins…”
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n-dimensional optical orthogonal codes, bounds and optimal constructions by Alderson, T. L.

“…We generalize to higher dimensions the notions of optical orthogonal codes. We establish upper bounds on the capacity of general n -dimensional OOCs, and on…”
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Conditional Disorder in Small Heat-shock Proteins by Alderson, T. Reid, Ying, Jinfa, Bax, Ad, Benesch, Justin L.P., Baldwin, Andrew J.

“…Small heat-shock proteins (sHSPs) are molecular chaperones that respond to cellular stresses to combat protein aggregation. HSP27 is a critical human sHSP that…”
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Parkinson's disease: Disorder in the court by Alderson, T Reid, Bax, Ad

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Automatic Assignment of Methyl-NMR Spectra of Supramolecular Machines Using Graph Theory by Pritišanac, Iva, Degiacomi, Matteo T, Alderson, T. Reid, Carneiro, Marta G, AB, Eiso, Siegal, Gregg, Baldwin, Andrew J

“…Methyl groups are powerful probes for the analysis of structure, dynamics and function of supramolecular assemblies, using both solution- and solid-state NMR…”
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Protein structural changes characterized by high-pressure, pulsed field gradient diffusion NMR spectroscopy by Ramanujam, Venkatraman, Alderson, T. Reid, Pritišanac, Iva, Ying, Jinfa, Bax, Ad

“…[Display omitted] •Changes in hydration radii of small molecules with pressure depend on hydrophobicity.•Diffusion of folded and unfolded proteins can be…”
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PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation by Chin Sang, Christopher, Moore, Gaelen, Tereshchenko, Maria, Zhang, Hongshan, Nosella, Michael L, Dasovich, Morgan, Alderson, T Reid, Leung, Anthony K L, Finkelstein, Ilya J, Forman-Kay, Julie D, Lee, Hyun O

“…Poly(ADP-ribose) polymerase 1 (PARP1) is one of the first responders to DNA damage and plays crucial roles in recruiting DNA repair proteins through its…”
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Disorder in the court by Alderson, T. Reid, Bax, Ad

“…The native structure of the protein α-synuclein, which is implicated in Parkinson's disease, is controversial. In-cell nuclear magnetic resonance now shows…”
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Tangled web of interactions among proteins involved in iron–sulfur cluster assembly as unraveled by NMR, SAXS, chemical crosslinking, and functional studies by Kim, Jin Hae, Bothe, Jameson R., Alderson, T. Reid, Markley, John L.

“…Proteins containing iron–sulfur (Fe–S) clusters arose early in evolution and are essential to life. Organisms have evolved machinery consisting of specialized…”
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Monitoring 15 N Chemical Shifts During Protein Folding by Pressure-Jump NMR by Charlier, Cyril, Courtney, Joseph M, Alderson, T Reid, Anfinrud, Philip, Bax, Ad

“…Pressure-jump hardware permits direct observation of protein NMR spectra during a cyclically repeated protein folding process. For a two-state folding protein,…”
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Proline isomerization in the C-terminal region of HSP27 by Alderson, T. Reid, Benesch, Justin L. P., Baldwin, Andrew J.

“…In mammals, small heat-shock proteins (sHSPs) typically assemble into interconverting, polydisperse oligomers. The dynamic exchange of sHSP oligomers is…”
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