Search Results - "Alderson, Mark R."

Status of research and development of pediatric vaccines for Streptococcus pneumoniae by Alderson, Mark R

“…Highlights • Pneumococcal conjugate vaccines (PCVs) have significantly reduced invasive pneumococcal disease (IPD) and pneumococcal pneumonia. • PCV impact on…”
Get full text

Development strategy and lessons learned for a 10-valent pneumococcal conjugate vaccine (PNEUMOSIL®) by Alderson, Mark R., Sethna, Vistasp, Newhouse, Lauren C., Lamola, Steve, Dhere, Rajeev

“…Pneumococcal conjugate vaccines (PCVs) have proven to be the best way to prevent severe childhood pneumococcal disease but until recently have been difficult…”
Get full text

Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination by Campo, Joseph J, Le, Timothy Q, Pablo, Jozelyn V, Hung, Christopher, Teng, Andy A, Tettelin, Hervé, Tate, Andrea, Hanage, William P, Alderson, Mark R, Liang, Xiaowu, Malley, Richard, Lipsitch, Marc, Croucher, Nicholas J

“…Pneumococcal whole cell vaccines (WCVs) could cost-effectively protect against a greater strain diversity than current capsule-based vaccines. Immunoglobulin G…”
Get full text

Defined tuberculosis vaccine, Mtb72F/AS02A, evidence of protection in cynomolgus monkeys by Reed, Steven G, Coler, Rhea N, Dalemans, Wilifred, Tan, Esterlina V, DeLa Cruz, Eduardo C, Basaraba, Randall J, Orme, Ian M, Skeiky, Yasir A.W, Alderson, Mark R, Cowgill, Karen D, Prieels, Jean-Paul, Abalos, Rodolfo M, Dubois, Marie-Claude, Cohen, Joe, Mettens, Pascal, Lobet, Yves

“…The development of a vaccine for tuberculosis requires a combination of antigens and adjuvants capable of inducing appropriate and long-lasting T cell…”
Get full text

Vaccines to Prevent Meningitis: Historical Perspectives and Future Directions by Alderson, Mark R, Welsch, Jo Anne, Regan, Katie, Newhouse, Lauren, Bhat, Niranjan, Marfin, Anthony A

“…Despite advances in the development and introduction of vaccines against the major bacterial causes of meningitis, the disease and its long-term after-effects…”
Get full text

Differential Immune Responses and Protective Efficacy Induced by Components of a Tuberculosis Polyprotein Vaccine, Mtb72F, Delivered as Naked DNA or Recombinant Protein by Skeiky, Yasir A. W, Alderson, Mark R, Ovendale, Pamela J, Guderian, Jeffrey A, Brandt, Lise, Dillon, Davin C, Campos-Neto, Antonio, Lobet, Yves, Dalemans, Wilfried, Orme, Ian M, Reed, Steven G

“…Key Ags of Mycobacterium tuberculosis initially identified in the context of host responses in healthy purified protein derivative-positive donors and infected…”
Get full text

Evaluation of Critical Quality Attributes of a Pentavalent (A, C, Y, W, X) Meningococcal Conjugate Vaccine for Global Use by Bolgiano, Barbara, Moran, Eilís, Beresford, Nicola J, Gao, Fang, Care, Rory, Desai, Trusha, Nordgren, Ida Karin, Rudd, Timothy R, Feavers, Ian M, Bore, Prashant, Patni, Sushil, Gavade, Vinay, Mallya, Asha, Kale, Sameer, Sharma, Pankaj, Goel, Sunil K, Gairola, Sunil, Hattarki, Suhas, Avalaskar, Nikhil, Sarma, Annamraju D, LaForce, Marc, Ravenscroft, Neil, Khandke, Lakshmi, Alderson, Mark R, Dhere, Rajeev M, Pisal, Sambhaji S

“…Towards achieving the goal of eliminating epidemic outbreaks of meningococcal disease in the African meningitis belt, a pentavalent glycoconjugate vaccine…”
Get full text

The Protective Effect of the Mycobacterium bovis BCG Vaccine Is Increased by Coadministration with the Mycobacterium tuberculosis 72-Kilodalton Fusion Polyprotein Mtb72F in M. tuberculosis-Infected Guinea Pigs by BRANDT, Lise, SKEIKY, Yasir A. W, REED, Steven G, ORME, Ian M, ALDERSON, Mark R, LOBET, Yves, DALEMANS, Wilfried, TURNER, Oliver C, BASARABA, Randall J, IZZO, Angelo A, LASCO, Todd M, CHAPMAN, Philip L

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Meningococcal Vaccine in Mali and Gambia. Reply by Clarke, Ed, Alderson, Mark R, Tapia, Milagritos D

Get full text

Differential Regulation of Inflammatory Cytokine Secretion by Human Dendritic Cells upon Chlamydia trachomatis Infection by GERVASSI, Ana, ALDERSON, Mark R, SUCHLAND, Robert, MAISONNEUVE, Jean Francois, GRABSTEIN, Kenneth H, PROBST, Peter

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

WHO consultation on group B Streptococcus vaccine development: Report from a meeting held on 27–28 April 2016 by Kobayashi, Miwako, Schrag, Stephanie J, Alderson, Mark R, Madhi, Shabir A, Baker, Carol J, Sobanjo-ter Meulen, Ajoke, Kaslow, David C, Smith, Peter G, Moorthy, Vasee S, Vekemans, Johan

“…Abstract Globally, group B Streptococcus (GBS) remains a leading cause of sepsis and meningitis in infants in the first 90 days of life. Intrapartum antibiotic…”
Get full text

Evaluation of the Mtb72F Polyprotein Vaccine in a Rabbit Model of Tuberculous Meningitis by TSENOVA, Liana, HARBACHEUSKI, Ryhor, MOREIRA, Andre L, ELLISON, Evette, DALEMANS, Wilfried, ALDERSON, Mark R, MATHEMA, Barun, REED, Steven G, SKEIKY, Yasir A. W, KAPLAN, Gilla

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Safety and immunogenicity of a pentavalent meningococcal conjugate vaccine containing serogroups A, C, Y, W, and X in healthy adults: a phase 1, single-centre, double-blind, randomised, controlled study by Chen, Wilbur H, Neuzil, Kathleen M, Boyce, C Rebecca, Pasetti, Marcela F, Reymann, Mardi K, Martellet, Lionel, Hosken, Nancy, LaForce, F Marc, Dhere, Rajeev M, Pisal, Sambhaji S, Chaudhari, Amol, Kulkarni, Prasad S, Borrow, Ray, Findlow, Helen, Brown, Valerie, McDonough, Megan L, Dally, Len, Alderson, Mark R

“…Invasive meningococcal disease is an important public health problem, especially in sub-Saharan Africa. After introduction of MenAfriVac in 2010, Neisseria…”
Get full text

Maternal immunization against Group B streptococcus: World Health Organization research and development technological roadmap and preferred product characteristics by Vekemans, Johan, Moorthy, Vasee, Friede, Martin, Alderson, Mark R., Sobanjo-Ter Meulen, Ajoke, Baker, Carol J., Heath, Paul T., Madhi, Shabir A., Mehring-Le Doare, Kirsty, Saha, Samir K., Schrag, Stephanie, Kaslow, David C.

“…Group B streptococcus, found in the vagina or lower gastrointestinal tract of about 10–40% of women of reproductive age, is a leading cause of early life…”
Get full text

A Phase 1 Randomized, Placebo-controlled, Observer-blinded Trial to Evaluate the Safety and Immunogenicity of Inactivated Streptococcus pneumoniae Whole-cell Vaccine in Adults by Keech, Cheryl A., Morrison, Royce, Anderson, Porter, Tate, Andrea, Flores, Jorge, Goldblatt, David, Briles, David, Hural, John, Malley, Richard, Alderson, Mark R.

“…BACKGROUND:Broadly protective pneumococcal vaccines that are affordable for low-resource countries are needed. Streptococcus pneumoniae whole cell vaccine…”
Get full text

Eliminating Meningococcal Epidemics From the African Meningitis Belt: The Case for Advanced Prevention and Control Using Next-Generation Meningococcal Conjugate Vaccines by Alderson, Mark R, LaForce, F Marc, Sobanjo-Ter Meulen, Ajoke, Hwang, Angela, Preziosi, Marie-Pierre, Klugman, Keith P

“…The introduction and rollout of a meningococcal serogroup A conjugate vaccine, MenAfriVac, in the African meningitis belt has eliminated serogroup A…”
Get full text

Immunogenicity and safety of a novel ten-valent pneumococcal conjugate vaccine in healthy infants in The Gambia: a phase 3, randomised, double-blind, non-inferiority trial by Clarke, Ed, Bashorun, Adedapo, Adigweme, Ikechukwu, Badjie Hydara, Mariama, Umesi, Ama, Futa, Ahmed, Ochoge, Magnus, Obayemi, Dolapo, Edem, Bassey, Saidy-Jah, Ebrima, Onwuchekwa, Chukwuemeka, Dhere, Rajeev, Sethna, Vistasp, Kampmann, Beate, Goldblatt, David, Taylor, Douglas, Andi-Lolo, Indah, Hosken, Nancy, Antony, Kalpana, Innis, Bruce L, Alderson, Mark R, Lamola, Steve

“…An affordable pneumococcal conjugate vaccine (PCV) is needed to ensure sustainable access in low-income and middle-income countries. This trial examined the…”
Get full text

Tracking Antigen-Specific CD8 T Lymphocytes in the Lungs of Mice Vaccinated with the Mtb72F Polyprotein by Irwin, Scott M, Izzo, Angelo A, Dow, Steven W, Skeiky, Y. A. W, Reed, Steven G, Alderson, Mark R, Orme, Ian M

“…This study used a major histocompatibility complex class I tetramer reagent to track antigen-specific CD8 T cells in the lungs of mice immunized with the…”
Get full text

Meningococcal ACWYX Conjugate Vaccine in 2-to-29-Year-Olds in Mali and Gambia by Haidara, Fadima C., Umesi, Ama, Sow, Samba O., Ochoge, Magnus, Diallo, Fatoumata, Imam, Abdulazeez, Traore, Youssouf, Affleck, Lucy, Doumbia, Moussa F., Daffeh, Bubacarr, Kodio, Mamoudou, Wariri, Oghenebrume, Traoré, Awa, Jallow, Edrissa, Kampmann, Beate, Kapse, Dhananjay, Kulkarni, Prasad S., Mallya, Asha, Goel, Sunil, Sharma, Pankaj, Sarma, Annamraju D., Avalaskar, Nikhil, LaForce, F. Marc, Alderson, Mark R., Naficy, Abdi, Lamola, Steve, Tang, Yuxiao, Martellet, Lionel, Hosken, Nancy, Simeonidis, Evangelos, Welsch, Jo Anne, Tapia, Milagritos D., Clarke, Ed

“…In a phase 3 noninferiority trial, one dose of a new meningococcal vaccine (NmCV-5) elicited immune responses similar to those of MenACWY-D for the four…”
Get full text

Surveillance and control of meningococcal disease in the COVID-19 era: A Global Meningococcal Initiative review by Alderson, Mark R., Arkwright, Peter D., Bai, Xilian, Black, Steve, Borrow, Ray, Caugant, Dominique A., Dinleyici, Ener Cagri, Harrison, Lee H., Lucidarme, Jay, McNamara, Lucy A., Meiring, Susan, Sáfadi, Marco A.P., Shao, Zhujun, Stephens, David S., Taha, Muhamed-Kheir, Vazquez, Julio, Zhu, Bingqing, collaborators, GMI

“…This review article incorporates information from the 4th Global Meningococcal Initiative summit meeting. Since the introduction of stringent COVID-19…”
Get full text