Search Results - "Alden, Ryan S."

Bias-Corrected Targeted Next-Generation Sequencing for Rapid, Multiplexed Detection of Actionable Alterations in Cell-Free DNA from Advanced Lung Cancer Patients by Paweletz, Cloud P, Sacher, Adrian G, Raymond, Chris K, Alden, Ryan S, O'Connell, Allison, Mach, Stacy L, Kuang, Yanan, Gandhi, Leena, Kirschmeier, Paul, English, Jessie M, Lim, Lee P, Jänne, Pasi A, Oxnard, Geoffrey R

“…Tumor genotyping is a powerful tool for guiding non-small cell lung cancer (NSCLC) care; however, comprehensive tumor genotyping can be logistically…”
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Acquired METD1228V Mutation and Resistance to MET Inhibition in Lung Cancer by Bahcall, Magda, Sim, Taebo, Paweletz, Cloud P, Patel, Jyoti D, Alden, Ryan S, Kuang, Yanan, Sacher, Adrian G, Kim, Nam Doo, Lydon, Christine A, Awad, Mark M, Jaklitsch, Michael T, Sholl, Lynette M, Jänne, Pasi A, Oxnard, Geoffrey R

“…Amplified and/or mutated MET can act as both a primary oncogenic driver and as a promoter of tyrosine kinase inhibitor (TKI) resistance in non-small cell lung…”
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Discrimination of Germline EGFR T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients by Hu, Yuebi, Alden, Ryan S, Odegaard, Justin I, Fairclough, Stephen R, Chen, Ruthia, Heng, Jennifer, Feeney, Nora, Nagy, Rebecca J, Shah, Jayshree, Ulrich, Bryan, Gutierrez, Martin, Lanman, Richard B, Garber, Judy E, Paweletz, Cloud P, Oxnard, Geoffrey R

“…Plasma cell-free DNA (cfDNA) analysis is increasingly used clinically for cancer genotyping, but may lead to incidental identification of germline-risk…”
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Next-generation sequencing informs diagnosis and identifies unexpected therapeutic targets in lung squamous cell carcinomas by Sands, Jacob M., Nguyen, Tom, Shivdasani, Priyanka, Sacher, Adrian G., Cheng, Michael L., Alden, Ryan S., Jänne, Pasi A., Kuo, Frank C., Oxnard, Geoffrey R., Sholl, Lynette M.

“…•Next generation sequencing squamous cell carcinoma is feasible for trial enrollment.•Targets are enriched in squamous cell carcinoma in light/never…”
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Glutamine metabolism and radiosensitivity: Beyond the Warburg effect by Alden, Ryan S., Kamran, Mohammad Zahid, Bashjawish, Bassel A., Simone, Brittany A.

“…Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation…”
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Association Between Plasma Genotyping and Outcomes of Treatment With Osimertinib (AZD9291) in Advanced Non-Small-Cell Lung Cancer by Oxnard, Geoffrey R, Thress, Kenneth S, Alden, Ryan S, Lawrance, Rachael, Paweletz, Cloud P, Cantarini, Mireille, Yang, James Chih-Hsin, Barrett, J Carl, Jänne, Pasi A

“…Third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have demonstrated potent activity against TKI resistance mediated by…”
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Prospective Validation of Rapid Plasma Genotyping for the Detection of EGFR and KRAS Mutations in Advanced Lung Cancer by Sacher, Adrian G, Paweletz, Cloud, Dahlberg, Suzanne E, Alden, Ryan S, O'Connell, Allison, Feeney, Nora, Mach, Stacy L, Jänne, Pasi A, Oxnard, Geoffrey R

“…Plasma genotyping of cell-free DNA has the potential to allow for rapid noninvasive genotyping while avoiding the inherent shortcomings of tissue genotyping…”
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Monitoring of Response and Resistance in Plasma of EGFR-Mutant Lung Cancer Using Droplet Digital PCR by Kuang, Yanan, O'Connell, Allison, Sacher, Adrian G, Feeney, Nora, Alden, Ryan S, Oxnard, Geoffrey R, Paweletz, Cloud P

“…The identification of oncogenic driver mutations has led to the rapid rise of genotype-directed treatments. However, genetic analysis of tumors remains…”
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Prognostic Factors in Limited-Stage Small Cell Lung Cancer: A Secondary Analysis of CALGB 30610-RTOG 0538 by Farris, Michael K, Mix, Michael D, Wang, Xiaofei, Jaszewski, Brandy, Foster, Nathan, Masters, Gregory A, Laurie, Fran, Smith, Koren, Razavian, Niema B, Alden, Ryan S, Komaki, Ritsuko, Stinchcombe, Thomas E, Bradley, Jeffrey D, Vokes, Everett E, Bogart, Jeffrey

“…The impact of patient-specific, disease-related, and social factors on outcomes in limited-stage small cell lung cancer (LS-SCLC) is not well defined. A post…”
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Designing a definitive trial for adjuvant targeted therapy in genotype defined lung cancer: the ALCHEMIST trials by Alden, Ryan S, Mandrekar, Sumithra J, Oxnard, Geoffrey R

“…Genotype-directed targeted therapies have revolutionized the treatment of metastatic non-small cell lung cancer (NSCLC) but they have not yet been…”
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Early Intervention in Lung Cancers With Rapid Plasma Genotyping for EGFR and KRAS Mutations-Reply by Sacher, Adrian G, Alden, Ryan S, Oxnard, Geoffrey R

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Abstract 4342: Ultra-deep next generation sequencing (NGS) of plasma cell-free DNA (cfDNA) from patients with advanced lung cancers: results from the Actionable Genome Consortium by Li, Bob T., Janku, Filip, Janne, Pasi A., Mills, Gordon B., Madwani, Kiran, Alden, Ryan S., Paweletz, Cloud P., Ladanyi, Marc, Aravanis, Alex, Jung, Byoungsok, Gnerre, Sante, Sehnert, Amy J., Solit, David B., Riely, Gregory J., Oxnard, Geoffrey R.

“…Abstract Introduction: Noninvasive genotyping using plasma cfDNA from cancer patients has the potential to obviate the need for some biopsies while also…”
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Poster 294: Resolution of Raynaud's Phenomenon in Hands After Injection of Onabotulintoxin A to Treat Cervical Dystonia by Zaccarini, Christina G., Alden, Ryan S., Casella, Gizelda T.

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Genomic complexity in KRAS mutant non-small cell lung cancer (NSCLC) from never/light-smokers v smokers by Redig, Amanda J., Chambers, Emily S., Lydon, Christine A., Dahlberg, Suzanne Eleanor, Alden, Ryan S., Janne, Pasi A.

“…Abstract only…”
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Abstract B104: Differentiating somatic and germline variants using targeted next-generation sequencing (NGS) of cell-free plasma DNA (cfDNA) by Oxnard, Geoffrey R., Sacher, Adrian G., Alden, Ryan S., Feeney, Nora B., Heng, Jennifer C., Nagy, Rebecca J., Lanman, Richard B., Paweletz, Cloud P., Janne, Pasi A.

“…Abstract Introduction: Genomic analysis of cfDNA is emerging as a powerful tool for noninvasive characterization of advanced cancer. Some cfDNA assays are…”
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