Search Results - "Alden, Nick"

Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-transcriptional Gene Regulation and Apoptosis of A549 Cells by Alden, Nick A., Arrizabalaga, Julien H., Liu, Yiming, Amin, Shantu, Gowda, Krishne, Yao, Shun, Archetti, Marco, Glick, Adam B., Hayes, Daniel J.

“…In this study, we utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in…”
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Liquid-Cell Electron Tomography of Biological Systems by Dearnaley, William J, Schleupner, Beatrice, Varano, A. Cameron, Alden, Nick A, Gonzalez, Floricel, Casasanta, Michael A, Scharf, Birgit E, Dukes, Madeline J, Kelly, Deborah F

“…Liquid-cell electron microscopy is a rapidly growing field in the imaging domain. While real-time observations are readily available to analyze materials and…”
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Adeno-associated virus perfusion enhanced expression: A commercially scalable, high titer, high quality producer cell line process by Xue, Wei, Fulco, Cameron, Sha, Sha, Alden, Nick, Panteli, Jan, Hossler, Patrick, Warren, James

“…With safety and efficacy demonstrated over hundreds of clinical trials in the last 30 years, along with at least six recent global marketing authorizations…”
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Near‐Infrared Induced miR‐34a Delivery from Nanoparticles in Esophageal Cancer Treatment by Alden, Nick A., Yeingst, Tyus J., Pfeiffer, Hanna M., Celik, Nazmiye, Arrizabalaga, Julien H., Helton, Angelica M., Liu, Yiming, Stairs, Douglas B., Glick, Adam B., Goyal, Neerav, Hayes, Daniel J.

“…Current nucleic acid delivery methods have not achieved efficient, non‐toxic delivery of miRNAs with tumor‐specific selectivity. In this study, a new delivery…”
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Cryo‐EM‐On‐a‐Chip: Custom‐Designed Substrates for the 3D Analysis of Macromolecules by Alden, Nick A., Varano, A. Cameron, Dearnaley, William J., Solares, Maria J., Luqiu, William Y., Liang, Yanping, Sheng, Zhi, McDonald, Sarah M., Damiano, John, McConnell, Jennifer, Dukes, Madeline J., Kelly, Deborah F.

“…The fight against human disease requires a multidisciplinary scientific approach. Applying tools from seemingly unrelated areas, such as materials science and…”
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Correcting errors in the BRCA1 warning system by Liang, Yanping, Dearnaley, William J., Alden, Nick A., Solares, Maria J., Gilmore, Brian L., Pridham, Kevin J., Varano, A. Cameron, Sheng, Zhi, Alli, Elizabeth, Kelly, Deborah F.

“…[Display omitted] •Functional properties of mutated BRCA1 can be restored biochemically.•Modulating BRCA1 affects the downstream activities of p53.•Structural…”
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Structural analysis of BRCA1 reveals modification hotspot by Liang, Yanping, Dearnaley, William J, Varano, A Cameron, Winton, Carly E, Gilmore, Brian L, Alden, Nick A, Sheng, Zhi, Kelly, Deborah F

“…Cancer cells afflicted with mutations in the breast cancer susceptibility protein (BRCA1) often suffer from increased DNA damage and genomic instability. The…”
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RETRACTED: Structural analysis of BRCA1 reveals modification hotspot by Liang, Yanping, Dearnaley, William J., Varano, A. Cameron, Winton, Carly E., Gilmore, Brian L., Alden, Nick A., Sheng, Zhi, Kelly, Deborah F.

“…Cracking the BRCA-BARD code—structural biology reveals the face of BRCA1. Cancer cells afflicted with mutations in the breast cancer susceptibility protein…”
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Cryo‐Electron Microscopy: Cryo‐EM‐On‐a‐Chip: Custom‐Designed Substrates for the 3D Analysis of Macromolecules (Small 21/2019) by Alden, Nick A., Varano, A. Cameron, Dearnaley, William J., Solares, Maria J., Luqiu, William Y., Liang, Yanping, Sheng, Zhi, McDonald, Sarah M., Damiano, John, McConnell, Jennifer, Dukes, Madeline J., Kelly, Deborah F.

“…In article number 1900918, Deborah F. Kelly and co‐workers develop a new cryo‐electron microscopy (EM)‐on‐a‐chip approach. This strategy enables researchers to…”
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