Search Results - "Aldegheri, Laura"

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile by Ward, Simon E, Harries, Mark H, Aldegheri, Laura, Bradford, Andrea M, Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R, Woolley, Marie

“…Purpose: There is considerable interest in positive allosteric modulators (PAMs) of the α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) subtype of…”
Get full text

Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay by Virginio, Caterina, Aldegheri, Laura, Nola, Selena, Brodbeck, Daniela, Brault, Laurent, Raveglia, Luca F., Barilli, Alessio, Sabat, Mark, Myers, Richard

“…Transient Receptor Potential Melastatin 5 (TRPM5) is an intracellular calcium-activated cation-selective ion channel expressed in a variety of cell types…”
Get full text

From High-Throughput Screening to Target Validation: Benzo[d]isothiazoles as Potent and Selective Agonists of Human Transient Receptor Potential Cation Channel Subfamily M Member 5 Possessing In Vivo Gastrointestinal Prokinetic Activity in Rodents by Barilli, Alessio, Aldegheri, Laura, Bianchi, Federica, Brault, Laurent, Brodbeck, Daniela, Castelletti, Laura, Feriani, Aldo, Lingard, Iain, Myers, Richard, Nola, Selena, Piccoli, Laura, Pompilio, Daniela, Raveglia, Luca F, Salvagno, Cristian, Tassini, Sabrina, Virginio, Caterina, Sabat, Mark

“…Transient receptor potential cation channel subfamily M member 5 (TRPM5) is a nonselective monovalent cation channel activated by intracellular Ca2+ increase…”
Get full text

A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons by Rosato-Siri, Marcelo D, Zambello, Erika, Mutinelli, Chiara, Garbati, Nicoletta, Benedetti, Roberto, Aldegheri, Laura, Graziani, Francesca, Virginio, Caterina, Alvaro, Giuseppe, Large, Charles H

“…Kv3.1 and Kv3.2 high voltage-activated potassium channels, which display fast activation and deactivation kinetics, are known to make a crucial contribution to…”
Get more information

Characterization of a New Hemoprotein in the YeastSaccharomyces cerevisiae by Sartori, Geppo, Aldegheri, Laura, Mazzotta, Gabriella, Lanfranchi, Gerolamo, Tournu, Helene, Brown, Alistair J.P., Carignani, Giovanna

“…The Saccharomyces cerevisiae gene YNL234w encodes a 426-amino acid-long protein that shares significant similarities with the globin family. Compared with…”
Get full text

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators by Ward, Simon E, Harries, Mark, Aldegheri, Laura, Austin, Nigel E, Ballantine, Stuart, Ballini, Elisa, Bradley, Daniel M, Bax, Benjamin D, Clarke, Brian P, Harris, Andrew J, Harrison, Stephen A, Melarange, Rosemary A, Mookherjee, Claudette, Mosley, Julie, Dal Negro, Gianni, Oliosi, Beatrice, Smith, Kathrine J, Thewlis, Kevin M, Woollard, Patrick M, Yusaf, Shahnaz P

“…A novel series of AMPAR positive modulators is described that were identified by high throughput screening. The molecules of the series have been optimized…”
Get full text

Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a Novel Clinical AMPA Receptor Positive Modulator by Ward, Simon E, Harries, Mark, Aldegheri, Laura, Andreotti, Daniele, Ballantine, Stuart, Bax, Benjamin D, Harris, Andrew J, Harker, Andy J, Lund, Jesper, Melarange, Rosemary, Mingardi, Anna, Mookherjee, Claudette, Mosley, Julie, Neve, Marta, Oliosi, Beatrice, Profeta, Roberto, Smith, Kathrine J, Smith, Paul W, Spada, Simone, Thewlis, Kevin M, Yusaf, Shahnaz P

“…A series of AMPA receptor positive allosteric modulators has been optimized from poorly penetrant leads to identify molecules with excellent preclinical…”
Get full text

N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators by Thewlis, Kevin M., Aldegheri, Laura, Harries, Mark H., Mookherjee, Claudette, Oliosi, Beatrice, Ward, Simon E.

“…This work describes the synthesis and biological activity of a series of pyrrolidine and tetrahydrofuran analogues as AMPA receptor positive modulators. Ar =…”
Get full text

Characterization of the Reverse Use Dependent Block of Voltage Gated Sodium Channels by Virginio, Caterina, Ballini, Elisa, Aldegheri, Laura, Castelletti, Laura, Capelli, AnnaMaria, Jarolimek, Wolfgang

Get full text

Optimisation of an integrated approach for cardiac safety profiling of novel compounds by Fasdelli, Nicola, Cunego, Luciano, Philip, David, Bertani, Simone, Giacometti, Angelo, Garbati, Nicoletta, Ballini, Elisa, Griffante, Cristiana, Aldegheri, Laura, Siri, Marcelo Rosato, Gerrard, Philip, Corsi, Mauro, Virginio, Caterina

Get full text

Pharmacological properties of rat α7 nicotinic receptors expressed in native and recombinant cell systems by Virginio, Caterina, Giacometti, Angelo, Aldegheri, Laura, Rimland, Joseph M, Terstappen, Georg C

“…The pharmacological properties of the rat α7 nicotinic acetylcholine receptor endogenously expressed in PC12 cells and recombinantly expressed in GH4C1 cells…”
Get full text

Pharmacological properties of rat alpha 7 nicotinic receptors expressed in native and recombinant cell systems by Virginio, Caterina, Giacometti, Angelo, Aldegheri, Laura, Rimland, Joseph M, Terstappen, Georg C

“…The pharmacological properties of the rat alpha7 nicotinic acetylcholine receptor endogenously expressed in PC12 cells and recombinantly expressed in GH4C1…”
Get full text

The antidepressant fluoxetine blocks the human small conductance calcium-activated potassium channels SK1, SK2 and SK3 by Terstappen, Georg C., Pellacani, Annalisa, Aldegheri, Laura, Graziani, Francesca, Carignani, Corrado, Pula, Giordano, Virginio, Caterina

“…The effects of fluoxetine (Prozac™) on the activity of human small-conductance calcium-activated potassium (SK) channels were investigated utilizing a…”
Get full text

Characterization of a new hemoprotein in the yeast Saccharomyces cerevisiae by Sartori, G, Aldegheri, L, Mazzotta, G, Lanfranchi, G, Tournu, H, Brown, A.J.P, Carignani, G

“…The Saccharomyces cerevisiae gene YNL234w encodes a 426-amino acid-long protein that shares significant similarities with the globin family. Compared with…”
Get full text