Determining conserved metabolic biomarkers from a million database queries

Determining conserved metabolic biomarkers from a million database queries

Metabolite databases provide a unique window into metabolome research allowing the most commonly searched biomarkers to be catalogued. Omic scale metabolite profiling, or metabolomics, is finding increased utility in biomarker discovery largely driven by improvements in analytical technologies and t...

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Bibliographic Details
Published in:Bioinformatics (Oxford, England) Vol. 31; no. 23; pp. 3721 - 3724
Main Authors: Kurczy, Michael E, Ivanisevic, Julijana, Johnson, Caroline H, Uritboonthai, Winnie, Hoang, Linh, Fang, Mingliang, Hicks, Matthew, Aldebot, Anthony, Rinehart, Duane, Mellander, Lisa J, Tautenhahn, Ralf, Patti, Gary J, Spilker, Mary E, Benton, H Paul, Siuzdak, Gary
Format: Journal Article
Language:English
Published: England Oxford University Press 01-12-2015
Subjects:
Biomarkers - metabolism
Databases, Factual
Discovery Note
Humans
Mass Spectrometry
Metabolome
Metabolomics
Online Access:Get full text
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Summary:Metabolite databases provide a unique window into metabolome research allowing the most commonly searched biomarkers to be catalogued. Omic scale metabolite profiling, or metabolomics, is finding increased utility in biomarker discovery largely driven by improvements in analytical technologies and the concurrent developments in bioinformatics. However, the successful translation of biomarkers into clinical or biologically relevant indicators is limited. With the aim of improving the discovery of translatable metabolite biomarkers, we present search analytics for over one million METLIN metabolite database queries. The most common metabolites found in METLIN were cross-correlated against XCMS Online, the widely used cloud-based data processing and pathway analysis platform. Analysis of the METLIN and XCMS common metabolite data has two primary implications: these metabolites, might indicate a conserved metabolic response to stressors and, this data may be used to gauge the relative uniqueness of potential biomarkers. METLIN can be accessed by logging on to: https://metlin.scripps.edu siuzdak@scripps.edu Supplementary data are available at Bioinformatics online.
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Associate Editor: Jonathan Wren
ISSN:1367-4803
1367-4811
DOI:10.1093/bioinformatics/btv475