Search Results - "Aldaz, C Marcelo"

WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders by Aldaz, C Marcelo, Hussain, Tabish

“…The gene was initially discovered as a putative tumor suppressor. More recently, its association with multiple central nervous system (CNS) pathologies has…”
Get full text

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies by Aldaz, C. Marcelo, Ferguson, Brent W., Abba, Martin C.

“…WWOX was cloned as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. Deletions affecting WWOX accompanied by loss of expression are…”
Get full text

WWOX, the FRA16D gene: A target of and a contributor to genomic instability by Hussain, Tabish, Liu, Bin, Shrock, Morgan S., Williams, Terence, Aldaz, C. Marcelo

“…WWOX is one of the largest human genes spanning over 1.11 Mbp in length at chr16q23.1‐q23.2 and containing FRA16D, the second most common chromosomal fragile…”
Get full text

Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer by Thangavel, Chellappagounder, Dean, Jeffry L, Ertel, Adam, Knudsen, Karen E, Aldaz, C Marcelo, Witkiewicz, Agnieszka K, Clarke, Robert, Knudsen, Erik S

“…The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine therapy. While this is effective, acquired resistance to therapies…”
Get full text

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved by Hussain, Tabish, Lee, Jaeho, Abba, Martin C, Chen, Junjie, Aldaz, C Marcelo

“…It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a "non-classical" tumor suppressor of significant…”
Get full text

Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System by Trinh, Anne, Gil Del Alcazar, Carlos R, Shukla, Sachet A, Chin, Koei, Chang, Young Hwan, Thibault, Guillaume, Eng, Jennifer, Jovanović, Bojana, Aldaz, C Marcelo, Park, So Yeon, Jeong, Joon, Wu, Catherine, Gray, Joe, Polyak, Kornelia

“…The drivers of ductal carcinoma (DCIS) to invasive ductal carcinoma (IDC) transition are poorly understood. Here, we conducted an integrated genomic,…”
Get full text

HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression by Abba, Martin C., Fabre, María Laura, Lee, Jaeho, Tatineni, Pradeep, Kil, Hyunsuk, Aldaz, C. Marcelo

“…The long-non-coding HOX transcript antisense intergenic RNA ( HOTAIR ) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS)…”
Get full text

Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus by Hussain, Tabish, Kil, Hyunsuk, Hattiangady, Bharathi, Lee, Jaeho, Kodali, Maheedhar, Shuai, Bing, Attaluri, Sahithi, Takata, Yoko, Shen, Jianjun, Abba, Martin C., Shetty, Ashok K., Aldaz, C. Marcelo

“…The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented…”
Get full text

Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice by Park, Dongju, Gharghabi, Mehdi, Reczek, Colleen R, Plow, Rebecca, Yungvirt, Charles, Aldaz, C Marcelo, Huebner, Kay

“…Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to…”
Get full text

LINC00885 a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression by Abba, Martin C, Canzoneri, Romina, Gurruchaga, Agustina, Lee, Jaeho, Tatineni, Pradeep, Kil, Hyunsuk, Lacunza, Ezequiel, Aldaz, C Marcelo

“…Long intergenic non-protein coding RNA 885 ( ) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was…”
Get full text

Differential expression in SAGE: accounting for normal between-library variation by Baggerly, Keith A., Deng, Li, Morris, Jeffrey S., Aldaz, C. Marcelo

“…Motivation: In contrasting levels of gene expression between groups of SAGE libraries, the libraries within each group are often combined and the counts for…”
Get full text

Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies by McBride, Kevin M, Kil, Hyunsuk, Mu, Yunxiang, Plummer, Joshua B, Lee, Jaeho, Zelazowski, Maciej J, Sebastian, Manu, Abba, Martin C, Aldaz, C Marcelo

“…(WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of…”
Get full text

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene by Ludes-Meyers, John H, Kil, Hyunsuk, Parker-Thornburg, Jan, Kusewitt, Donna F, Bedford, Mark T, Aldaz, C Marcelo

“…WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor…”
Get full text

Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn’s Disease by Visschedijk, Marijn C, Spekhorst, Lieke M, Cheng, Shih-Chin, van Loo, Ellen S, Jansen, B H Dianne, Blokzijl, Tjasso, Kil, Hyunsuk, de Jong, Dirk J, Pierik, Marieke, Maljaars, Jeroen P W J, van der Woude, C Janneke, van Bodegraven, Adriaan A, Oldenburg, Bas, Löwenberg, Mark, Nieuwenhuijs, Vincent B, Imhann, Floris, van Sommeren, Suzanne, Alberts, Rudi, Xavier, Ramnik J, Dijkstra, Gerard, Nico Faber, Klaas, Marcelo Aldaz, C, Weersma, Rinse K, Festen, Eleonora A M

“…Abstract Background and Aims Crohn’s disease [CD] is a chronic inflammatory disease with unpredictable behaviour. More than half of CD patients eventually…”
Get full text

Activation of the canonical Wnt/β-catenin pathway in ATF3-induced mammary tumors by Yan, Leqin, Della Coletta, Luis, Powell, K Leslie, Shen, Jianjun, Thames, Howard, Aldaz, C Marcelo, MacLeod, Michael C

“…Female transgenic mice that constitutively overexpress the transcription factor ATF3 in the basal epithelium of the mammary gland develop mammary carcinomas…”
Get full text

The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding by Ferguson, Brent W, Gao, Xinsheng, Zelazowski, Maciej J, Lee, Jaeho, Jeter, Collene R, Abba, Martin C, Aldaz, C Marcelo

“…The WW domain containing protein WWOX has been postulated to behave as a tumor suppressor in breast and other cancers. Expression of this protein is lost in…”
Get full text

Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches by Ferguson, Brent W, Gao, Xinsheng, Kil, Hyunsuk, Lee, Jaeho, Benavides, Fernando, Abba, Martin C, Aldaz, C Marcelo

“…Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not…”
Get full text

Specific Protein Methylation Defects and Gene Expression Perturbations in Coactivator-Associated Arginine Methyltransferase 1-Deficient Mice by Yadav, Neelu, Lee, Jaeho, Kim, Jeesun, Shen, Jianjun, Mickey C. -T. Hu, Aldaz, C. Marcelo, Bedford, Mark T.

“…Arginine methylation has been implicated in the regulation of gene expression. The coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds the…”
Get full text

Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status by Abba, Martín C, Sun, Hongxia, Hawkins, Kathleen A, Drake, Jeffrey A, Hu, Yuhui, Nunez, Maria I, Gaddis, Sally, Shi, Tao, Horvath, Steve, Sahin, Aysegul, Aldaz, C Marcelo

“…Global gene expression measured by DNA microarray platforms have been extensively used to classify breast carcinomas correlating with clinical characteristics,…”
Get full text

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins by LUDES-MEYERS, John H, KIL, Hyunsuk, BEDNAREK, Andrzej K, DRAKE, Jeff, BEDFORD, Mark T, ALDAZ, C. Marcelo

“…WWOX, the gene that maps to common chromosomal fragile site FRA16D, is frequently affected by aberrations in multiple types of cancers. WWOX encodes a 46 kDa…”
Get full text