Search Results - "Aldape, K."

Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells by DAI, B, KANG, S.-H, GONG, W, LIU, M, ALDAPE, K. D, SAWAYA, R, HUANG, S

“…We recently showed that FoxM1 is overexpressed in human glioblastomas and that forced FoxM1B expression in anaplastic astrocytoma cells leads to the formation…”
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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma by Molina, J R, Agarwal, N K, Morales, F C, Hayashi, Y, Aldape, K D, Cote, G, Georgescu, M-M

“…The phosphatidylinositol-3-OH kinase (PI3K)-Akt pathway is activated in cancer by genetic or epigenetic events and efforts are under way to develop targeted…”
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Defining prognosis for women with breast cancer and CNS metastases by HER2 status by Dawood, S., Broglio, K., Esteva, F.J., Ibrahim, N.K., Kau, S.-W., Islam, R., Aldape, K.D., Yu, T.-K., Hortobagyi, G.N., Gonzalez-Angulo, A.M.

“…The purpose of this retrospective study was to determine, in a cohort of patients with breast cancer and central nervous system (CNS) metastases, the effect of…”
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Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours by Singh, R R, Patel, K P, Routbort, M J, Aldape, K, Lu, X, Manekia, J, Abraham, R, Reddy, N G, Barkoh, B A, Veliyathu, J, Medeiros, L J, Luthra, R

“…Background: In a clinical diagnostic laboratory, we evaluated the applicability of the Ion Proton sequencer for screening 409 cancer-related genes in solid…”
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Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors by Singh, Melissa M., Manton, Christa A., Bhat, Krishna P., Tsai, Wen-Wei, Aldape, Kenneth, Barton, Michelle C., Chandra, Joya

“…Glioblastoma multiforme (GBM) is a particularly aggressive brain tumor and remains a clinically devastating disease. Despite innovative therapies for the…”
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A phase II study of bevacizumab and erlotinib after radiation and temozolomide in MGMT unmethylated GBM patients by Raizer, J. J., Giglio, P., Hu, J., Groves, M., Merrell, R., Conrad, C., Phuphanich, S., Puduvalli, V. K., Loghin, M., Paleologos, N., Yuan, Y., Liu, D., Rademaker, A., Yung, W. K., Vaillant, B., Rudnick, J., Chamberlain, M., Vick, N., Grimm, S., Tremont-Lukats, I. W., De Groot, J., Aldape, K., Gilbert, M. R.

“…Survival for glioblastoma (GBM) patients with an unmethyated MGMT promoter in their tumor is generally worse than methylated MGMT tumors, as temozolomide (TMZ)…”
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Radiologically evident treatment effects in patients with glioblastoma (GBM) and its clinical implications by Gan, H.K., Murone, C., Wong, M., Fitt, G., Kennedy, E., Maag, D., Aldape, K.

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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy by Mack, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H., Head, R., Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A., Taylor, M. D.

“…Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard…”
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A mosaic mouse model of astrocytoma identifies αvβ8 integrin as a negative regulator of tumor angiogenesis by Tchaicha, J H, Mobley, A K, Hossain, M G, Aldape, K D, McCarty, J H

“…Angiogenesis involves a complex set of cell–cell and cell–extracellular matrix (ECM) interactions that coordinately promote and inhibit blood vessel growth and…”
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Formation of intracranial tumors by genetically modified human astrocytes defines four pathways critical in the development of human anaplastic astrocytoma by SONODA, Yukihiko, OZAWA, Tomoko, HIROSE, Yuichi, ALDAPE, Ken D, MCMAHON, Martin, BERGER, Mitchel S, PIEPER, Russell O

“…The formation of human malignant gliomas is thought to involve the accumulation of multiple genetic alterations. To define the function of specific alterations…”
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Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma by SONODA, Yukihiko, OZAWA, Tomoko, ALDAPE, Ken D, DEEN, Dennis F, BERGER, Mitchel S, PIEPER, Russell O

“…Human malignant gliomas are thought to develop as the result of stepwise accumulations of multiple genetic alterations. Recently, we showed that E6/E7-mediated…”
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GBM's multifaceted landscape: highlighting regional and microenvironmental heterogeneity by Vartanian, Alenoush, Singh, Sanjay K, Agnihotri, Sameer, Jalali, Shahrzad, Burrell, Kelly, Aldape, Kenneth D, Zadeh, Gelareh

“…Gliomas are a heterogeneous group of tumors that show variable proliferative potential, invasiveness, aggressiveness, histological grading, and clinical…”
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Phase II study of carboplatin and erlotinib (Tarceva, OSI-774) in patients with recurrent glioblastoma by de Groot, J. F., Gilbert, M. R., Aldape, K., Hess, K. R., Hanna, T. A., Ictech, S., Groves, M. D., Conrad, C., Colman, H., Puduvalli, V. K., Levin, V., Yung, W. K. A.

“…Targeting the epidermal growth factor receptor (EGFR) may be effective in a subset of glioblastoma patients. This phase II study assessed the clinical activity…”
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A Mutation and Prognostic Biomarker Study in Grade II and III Gliomas Utilizing a Combined Cohort of NRG Oncology/RTOG 9802 and 9813 by Bell, E.H, McElroy, J.P, Fleming, J, Timmers, C, Chakraborty, A.R, Salavaggione, A.L, Chang, S.M, Shaw, E.G, Aldape, K, Brachman, D, Schultz, C.J, Shih, H.A, Curtis, M, Hunter, G.K, Murtha, A.D, Zhang, P, Won, M, Mehta, M.P, Chakravarti, A

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MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma by Rivera, Andreana L, Pelloski, Christopher E, Gilbert, Mark R, Colman, Howard, De La Cruz, Clarissa, Sulman, Erik P, Bekele, B Nebiyou, Aldape, Kenneth D

“…Hypermethylation of the O(6)-methylguanine-DNA-methyltransferase (MGMT) gene has been shown to be associated with improved outcome in glioblastoma (GBM) and…”
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NRG Oncology/RTOG 0525 Role of Machine Learning Analytic Tools for Survival Prediction of GBM Patients Using Clinical Parameters by Zhang, H.H, Zhang, P, Gilbert, M.R, Aldape, K, Chakravarti, A, Magliocco, A, Klimowicz, A, D'Souza, W.D, Corn, B.W, Hunter, G.K, Muanza, T.M, Dicker, A.P, Vigneault, E, Brachman, D.G, Bovi, J.A, Robins, H.I, Sahijdak, W.M, Won, M, Mehta, M.P

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A Molecular Signature to Predict Meningioma Recurrence and Progression by Sulman, E.P, Ezhilarasan, R, Goodman, L, Wani, K, Sharma, D, Mody, R, Cloughesy, T, Lai, A, DeMonte, F, Aldape, K

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Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy by Brenman, Jay E, Chao, Daniel S, Xia, Houhui, Aldape, Ken, Bredt, David S

“…Nitric oxide (NO) is synthesized in skeletal muscle by neuronal-type NO synthase (nNOS), which is localized to sarcolemma of fast-twitch fibers. Synthesis of…”
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O8.10 A MODEL FOR RESEARCH INITIATIVES FOR RARE CANCERS: THE COLLABORATIVE EPENDYMOMA RESEARCH NETWORK (CERN) by Armstrong, T. S., Aldape, K., Gajjar, A., Haynes, C., Hirakawa, D., Gilbertson, R., Gilbert, M. R.

“…Ependymoma represents less than 5% of adult central nervous system (CNS) tumors and a higher percentage of pediatric CNS tumors, but it remains an orphan…”
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A model of molecular interactions on short oligonucleotide microarrays by Zhang, Li, Miles, Michael F, Aldape, Kenneth D

“…High-density short oligonucleotide microarrays have become a widely used tool for measuring gene expression on a large scale. However, details of the mechanism…”
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