Search Results - "Alcolea, D."

Differential levels of Neurofilament Light protein in cerebrospinal fluid in patients with a wide range of neurodegenerative disorders by Delaby, C., Alcolea, D., Carmona-Iragui, M., Illán-Gala, I., Morenas-Rodríguez, E., Barroeta, I., Altuna, M., Estellés, T., Santos-Santos, M., Turon-Sans, J., Muñoz, L., Ribosa-Nogué, R., Sala-Matavera, I., Sánchez-Saudinos, B., Subirana, A., Videla, L., Benejam, B., Sirisi, S., Lehmann, S., Belbin, O., Clarimon, J., Blesa, R., Pagonabarraga, J., Rojas-Garcia, R., Fortea, J., Lleó, A.

“…Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and the prediction of progression of several neurodegenerative diseases. Among them, CSF…”
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Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease by Rodríguez-Rodríguez, E., Sánchez-Juan, P., Vázquez-Higuera, J. L., Mateo, I., Pozueta, A., Berciano, J., Cervantes, S., Alcolea, D., Martínez-Lage, P., Clarimón, J., Lleó, A., Pastor, P., Combarros, O.

“…Aside from APOE , the genetic factors that influence the progression from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) remain largely unknown…”
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Add specialty to your routine: reviewing a new anti-Mullerian hormone assay and the first complete panel for fully automated biomarker testing in Alzheimer's disease by van den Berg, S., Alcolea, D.

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The MS4A gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk by Deming, Yuetiva, Filipello, Fabia, Cignarella, Francesca, Cantoni, Claudia, Hsu, Simon, Mikesell, Robert, Li, Zeran, Del-Aguila, Jorge L, Dube, Umber, Farias, Fabiana Geraldo, Bradley, Joseph, Budde, John, Ibanez, Laura, Fernandez, Maria Victoria, Blennow, Kaj, Zetterberg, Henrik, Heslegrave, Amanda, Johansson, Per M, Svensson, Johan, Nellgård, Bengt, Lleo, Alberto, Alcolea, Daniel, Clarimon, Jordi, Rami, Lorena, Molinuevo, José Luis, Suárez-Calvet, Marc, Morenas-Rodríguez, Estrella, Kleinberger, Gernot, Ewers, Michael, Harari, Oscar, Haass, Christian, Brett, Thomas J, Benitez, Bruno A, Karch, Celeste M, Piccio, Laura, Cruchaga, Carlos

“…Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a…”
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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis by Kleinberger, Gernot, Yamanishi, Yoshinori, Suárez-Calvet, Marc, Czirr, Eva, Lohmann, Ebba, Cuyvers, Elise, Struyfs, Hanne, Pettkus, Nadine, Wenninger-Weinzierl, Andrea, Mazaheri, Fargol, Tahirovic, Sabina, Lleó, Alberto, Alcolea, Daniel, Fortea, Juan, Willem, Michael, Lammich, Sven, Molinuevo, José L, Sánchez-Valle, Raquel, Antonell, Anna, Ramirez, Alfredo, Heneka, Michael T, Sleegers, Kristel, van der Zee, Julie, Martin, Jean-Jacques, Engelborghs, Sebastiaan, Demirtas-Tatlidede, Asli, Zetterberg, Henrik, Van Broeckhoven, Christine, Gurvit, Hakan, Wyss-Coray, Tony, Hardy, John, Colonna, Marco, Haass, Christian

“…Genetic variants in the triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to Nasu-Hakola disease, Alzheimer's disease (AD), Parkinson's…”
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Use of plasma biomarkers for AT(N) classification of neurodegenerative dementias by Alcolea, Daniel, Delaby, Constance, Muñoz, Laia, Torres, Soraya, Estellés, Teresa, Zhu, Nuole, Barroeta, Isabel, Carmona-Iragui, María, Illán-Gala, Ignacio, Santos-Santos, Miguel Ángel, Altuna, Miren, Sala, Isabel, Sánchez-Saudinós, Mª Belén, Videla, Laura, Valldeneu, Sílvia, Subirana, Andrea, Pegueroles, Jordi, Hirtz, Christophe, Vialaret, Jérôme, Lehmann, Sylvain, Karikari, Thomas K, Ashton, Nicholas J, Blennow, Kaj, Zetterberg, Henrik, Belbin, Olivia, Blesa, Rafael, Clarimón, Jordi, Fortea, Juan, Lleó, Alberto

“…ObjectivesAll categories included in the AT(N) classification can now be measured in plasma. However, their agreement with cerebrospinal fluid (CSF) markers is…”
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity by van der Lee, Sven J., Conway, Olivia J., Jansen, Iris, Carrasquillo, Minerva M., Kleineidam, Luca, van den Akker, Erik, Hernández, Isabel, van Eijk, Kristel R., Stringa, Najada, Chen, Jason A., Zettergren, Anna, Andlauer, Till F. M., Diez-Fairen, Monica, Simon-Sanchez, Javier, Lleó, Alberto, Zetterberg, Henrik, Nygaard, Marianne, Blauwendraat, Cornelis, Savage, Jeanne E., Mengel-From, Jonas, Moreno-Grau, Sonia, Wagner, Michael, Fortea, Juan, Keogh, Michael J., Blennow, Kaj, Skoog, Ingmar, Friese, Manuel A., Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Tesi, Niccolo, Morris, Christopher M., Indakoetxea, Begoña, Collij, Lyduine E., Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W., van Berckel, Bart N. M., Wiendl, Heinz, Strickland, Samantha L., Pastor, Pau, Rodríguez Rodríguez, Eloy, Boeve, Bradley F., Petersen, Ronald C., Ferman, Tanis J., van Gerpen, Jay A., Reinders, Marcel J. T., Uitti, Ryan J., Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, Boada, Mercè, Zettl, Uwe K., van Schoor, Natasja M., Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K., Ross, Owen A., Dickson, Dennis W., Graff-Radford, Neill R., Knopman, David, Rademakers, Rosa, Lemstra, Afina W., Pijnenburg, Yolande A. L., Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Huisman, Martijn A., Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A., Sørensen, Thorkild I. A., Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, Clarimón, Jordi, Christensen, Kaare, Ertekin-Taner, Nilüfer, Scholz, Sonja W., Ramirez, Alfredo, Ruiz, Agustín, Slagboom, Eline, van der Flier, Wiesje M., Holstege, Henne

“…The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in…”
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Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer’s disease in adults with Down syndrome by Lleó, Alberto, Zetterberg, Henrik, Pegueroles, Jordi, Karikari, Thomas K., Carmona-Iragui, María, Ashton, Nicholas J., Montal, Victor, Barroeta, Isabel, Lantero-Rodríguez, Juan, Videla, Laura, Altuna, Miren, Benejam, Bessy, Fernandez, Susana, Valldeneu, Silvia, Garzón, Diana, Bejanin, Alexandre, Iulita, Maria Florencia, Camacho, Valle, Medrano-Martorell, Santiago, Belbin, Olivia, Clarimon, Jordi, Lehmann, Sylvain, Alcolea, Daniel, Blesa, Rafael, Blennow, Kaj, Fortea, Juan

“…Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer’s disease (AD) pathology with high accuracy in the general population. In this study,…”
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Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study by Lleó, Alberto, Alcolea, Daniel, Martínez-Lage, Pablo, Scheltens, Philip, Parnetti, Lucilla, Poirier, Judes, Simonsen, Anja H., Verbeek, Marcel M., Rosa-Neto, Pedro, Slot, Rosalinde E.R., Tainta, Mikel, Izaguirre, Andrea, Reijs, Babette L.R., Farotti, Lucia, Tsolaki, Magda, Vandenbergue, Rik, Freund-Levi, Yvonne, Verhey, Frans R.J., Clarimón, Jordi, Fortea, Juan, Frolich, Lutz, Santana, Isabel, Molinuevo, José Luis, Lehmann, Sylvain, Visser, Pieter J., Teunissen, Charlotte E., Zetterberg, Henrik, Blennow, Kaj

“…Within-person trajectories of cerebrospinal fluid (CSF) biomarkers in Alzheimer's disease (AD) are not well defined. We included 467 subjects from the…”
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Blood amyloid and tau biomarkers as predictors of cerebrospinal fluid profiles by Delaby, Constance, Alcolea, Daniel, Hirtz, Christophe, Vialaret, Jérôme, Kindermans, Jana, Morichon, Lisa, Fortea, Juan, Belbin, Olivia, Gabelle, Audrey, Blennow, Kaj, Zetterberg, Henrik, Lleó, Alberto, Lehmann, Sylvain

“…Introduction Blood biomarkers represent a major advance for improving the management, diagnosis, and monitoring of Alzheimer's disease (AD). However, their…”
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Characteristics of subjective cognitive decline associated with amyloid positivity by Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J.B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, José Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stéphane, Lleó, Alberto, Engelborghs, Sebastiaan, Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chételat, Gaël, Ruíz, Agustin, Marquié, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort‐Merino, Adrià, Binette, Alexa Pichet, Poirier, Judes, Rosa‐Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sánchez‐Saudinós, M. Belén, Ebenau, Jarith, Pocnet, Cornelia, Eckerström, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund‐Levi, Yvonne, Wallin, Åsa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, Visser, Pieter Jelle

“…Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640…”
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SMA - TREATMENT: EP.294 Determination of cerebrospinal fluid and serum neurofilament (pNF-H) concentration in type 2 and type 3 SMA children under Nusinersen treatment by Trifunov, S., Carrera, L., Escudero, J. Exposito, Codina, A., Natera-de Benito, D., Ortez, C., Medina, J., Bernal, S., Alias, L., Badosa, C., Torres, S., Alcolea, D., Nascimento, A., Jimenez-Mallebrera, C.

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SMA - TREATMENT by Trifunov, S., Carrera, L., Escudero, J. Exposito, Codina, A., Natera-de Benito, D., Ortez, C., Medina, J., Bernal, S., Alias, L., Badosa, C., Torres, S., Alcolea, D., Nascimento, A., Jimenez-Mallebrera, C.

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Characterization of the repeat expansion size in C9orf72 in amyotrophic lateral sclerosis and frontotemporal dementia by Dols-Icardo, Oriol, García-Redondo, Alberto, Rojas-García, Ricard, Sánchez-Valle, Raquel, Noguera, Aina, Gómez-Tortosa, Estrella, Pastor, Pau, Hernández, Isabel, Esteban-Pérez, Jesús, Suárez-Calvet, Marc, Antón-Aguirre, Sofía, Amer, Guillermo, Ortega-Cubero, Sara, Blesa, Rafael, Fortea, Juan, Alcolea, Daniel, Capdevila, Aura, Antonell, Anna, Lladó, Albert, Muñoz-Blanco, José Luís, Mora, Jesús S, Galán-Dávila, Lucía, Rodríguez De Rivera, Francisco Javier, Lleó, Alberto, Clarimón, Jordi

“…Hexanucleotide repeat expansions within the C9orf72 gene are the most important genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal…”
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TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels by Hong, Shengjun, Dobricic, Valerija, Ohlei, Olena, Bos, Isabelle, Vos, Stephanie J. B., Prokopenko, Dmitry, Tijms, Betty M., Andreasson, Ulf, Blennow, Kaj, Vandenberghe, Rik, Gabel, Silvy, Scheltens, Philip, Teunissen, Charlotte E., Engelborghs, Sebastiaan, Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C., Bordet, Regis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Clark, Christopher, Peyratout, Gwendoline, Martinez‐Lage, Pablo, Tainta, Mikel, Dobson, Richard J. B., Legido‐Quigley, Cristina, Sleegers, Kristel, Van Broeckhoven, Christine, Tanzi, Rudolph E., ten Kate, Mara, Wittig, Michael, Franke, Andre, Lill, Christina M., Barkhof, Frederik, Lovestone, Simon, Streffer, Johannes, Zetterberg, Henrik, Visser, Pieter Jelle, Bertram, Lars

“…Introduction Neurofilament light (NfL), chitinase‐3‐like protein 1 (YKL‐40), and neurogranin (Ng) are biomarkers for Alzheimer's disease (AD) to monitor axonal…”
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Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome by Rozalem Aranha, Mateus, Iulita, Maria Florencia, Montal, Victor, Pegueroles, Jordi, Bejanin, Alexandre, Vaqué-Alcázar, Lídia, Grothe, Michel J, Carmona-Iragui, Maria, Videla, Laura, Benejam, Bessy, Arranz, Javier, Padilla, Concepción, Valldeneu, Sílvia, Barroeta, Isabel, Altuna, Miren, Fernández, Susana, Ribas, Laia, Valle-Tamayo, Natalia, Alcolea, Daniel, González-Ortiz, Sofía, Bargalló, Núria, Zetterberg, Henrik, Blennow, Kaj, Blesa, Rafael, Wisniewski, Thomas, Busciglio, Jorge, Cuello, A Claudio, Lleó, Alberto, Fortea, Juan

“…Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease…”
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A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort by Stamate, Daniel, Kim, Min, Proitsi, Petroula, Westwood, Sarah, Baird, Alison, Nevado-Holgado, Alejo, Hye, Abdul, Bos, Isabelle, Vos, Stephanie J.B., Vandenberghe, Rik, Teunissen, Charlotte E., Kate, Mara Ten, Scheltens, Philip, Gabel, Silvy, Meersmans, Karen, Blin, Olivier, Richardson, Jill, De Roeck, Ellen, Engelborghs, Sebastiaan, Sleegers, Kristel, Bordet, Régis, Ramit, Lorena, Kettunen, Petronella, Tsolaki, Magda, Verhey, Frans, Alcolea, Daniel, Lléo, Alberto, Peyratout, Gwendoline, Tainta, Mikel, Johannsen, Peter, Freund-Levi, Yvonne, Frölich, Lutz, Dobricic, Valerija, Frisoni, Giovanni B., Molinuevo, José L., Wallin, Anders, Popp, Julius, Martinez-Lage, Pablo, Bertram, Lars, Blennow, Kaj, Zetterberg, Henrik, Streffer, Johannes, Visser, Pieter J., Lovestone, Simon, Legido-Quigley, Cristina

“…Machine learning (ML) may harbor the potential to capture the metabolic complexity in Alzheimer Disease (AD). Here we set out to test the performance of…”
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Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset by Homann, Jan, Osburg, Tim, Ohlei, Olena, Dobricic, Valerija, Deecke, Laura, Bos, Isabelle, Vandenberghe, Rik, Gabel, Silvy, Scheltens, Philip, Teunissen, Charlotte E, Engelborghs, Sebastiaan, Frisoni, Giovanni, Blin, Olivier, Richardson, Jill C, Bordet, Regis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Clark, Christopher, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Dobson, Richard J B, Legido-Quigley, Cristina, Sleegers, Kristel, Van Broeckhoven, Christine, Wittig, Michael, Franke, Andre, Lill, Christina M, Blennow, Kaj, Zetterberg, Henrik, Lovestone, Simon, Streffer, Johannes, Ten Kate, Mara, Vos, Stephanie J B, Barkhof, Frederik, Visser, Pieter Jelle, Bertram, Lars

“…Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. AD susceptibility…”
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Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation by Suárez-Calvet, Marc, Dols-Icardo, Oriol, Lladó, Albert, Sánchez-Valle, Raquel, Hernández, Isabel, Amer, Guillermo, Antón-Aguirre, Sofía, Alcolea, Daniel, Fortea, Juan, Ferrer, Isidre, van der Zee, Julie, Dillen, Lubina, Van Broeckhoven, Christine, Molinuevo, José Luís, Blesa, Rafael, Clarimón, Jordi, Lleó, Alberto

“…Objectives About a half of patients with frontotemporal dementia (FTD) has deposition of phosphorylated TDP-43 protein (pTDP-43) in the brain. We studied…”
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Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning by Neumann, Alexander, Ohlei, Olena, Küçükali, Fahri, Bos, Isabelle J, Timsina, Jigyasha, Vos, Stephanie, Prokopenko, Dmitry, Tijms, Betty M, Andreasson, Ulf, Blennow, Kaj, Vandenberghe, Rik, Scheltens, Philip, Teunissen, Charlotte E, Engelborghs, Sebastiaan, Frisoni, Giovanni B, Blin, Oliver, Richardson, Jill C, Bordet, Régis, Lleó, Alberto, Alcolea, Daniel, Popp, Julius, Marsh, Thomas W, Gorijala, Priyanka, Clark, Christopher, Peyratout, Gwendoline, Martinez-Lage, Pablo, Tainta, Mikel, Dobson, Richard J B, Legido-Quigley, Cristina, Van Broeckhoven, Christine, Tanzi, Rudolph E, Ten Kate, Mara, Lill, Christina M, Barkhof, Frederik, Cruchaga, Carlos, Lovestone, Simon, Streffer, Johannes, Zetterberg, Henrik, Visser, Pieter Jelle, Sleegers, Kristel, Bertram, Lars

“…Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF)…”
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